FBX42_HUMAN 2019

Gene Name FBX42

Description F-box only protein 42

Length 717

9606

Sequence

>sp|Q6P3S6|FBX42_HUMAN F-box only protein 42
MASSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

S12A8_HUMAN

Solute carrier family 12 member 8

0.298

FEZF1_HUMAN

Fez family zinc finger protein 1

0.298

HINFP_HUMAN

Histone H4 transcription factor

0.326

ZO1_HUMAN

Tight junction protein ZO-1

0.326

HMX3_HUMAN

Homeobox protein HMX3

0.330

DAG1_HUMAN

Dystroglycan

0.330

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.333

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein

0.333

VSX2_HUMAN

Visual system homeobox 2

0.337

NET1_HUMAN

Netrin-1

0.354

AT1B4_HUMAN

Protein ATP1B4

0.354

HLF_HUMAN

Hepatic leukemia factor

0.354

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.354

DACH2_HUMAN

Dachshund homolog 2

0.357

CSTN1_HUMAN

Calsyntenin-1

0.357

BTBD7_HUMAN

BTB/POZ domain-containing protein 7

0.357

ZO2_HUMAN

Tight junction protein ZO-2

0.357

DACH1_HUMAN

Dachshund homolog 1

0.357

RABE1_HUMAN

Rab GTPase-binding effector protein 1

0.357

FEZF2_HUMAN

Fez family zinc finger protein 2

0.361

CEBPG_HUMAN

CCAAT/enhancer-binding protein gamma

0.361

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.361

NID1_HUMAN

Nidogen-1

0.361

SNAI2_HUMAN

Zinc finger protein SNAI2

0.361

K2013_HUMAN

Uncharacterized protein KIAA2013

0.361

APLP1_HUMAN

Amyloid-like protein 1

0.365

NEGR1_HUMAN

Neuronal growth regulator 1

0.365

TMCC3_HUMAN

Transmembrane and coiled-coil domain protein 3

0.365

BIG3_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

0.365

TRIB2_HUMAN

Tribbles homolog 2

0.365

GFI1_HUMAN

Zinc finger protein Gfi-1

0.378

WLS_HUMAN

Protein wntless homolog

0.378

NKX61_HUMAN

Homeobox protein Nkx-6.1

0.382

PTPRN_HUMAN

Receptor-type tyrosine-protein phosphatase-like N

0.382

FABP7_HUMAN

Fatty acid-binding protein, brain

0.382

RIPL1_HUMAN

RILP-like protein 1

0.382

FOXO3_HUMAN

Forkhead box protein O3

0.382

VANG1_HUMAN

Vang-like protein 1

0.382

E41L5_HUMAN

Band 4.1-like protein 5

0.382

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.382

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.382

TEF_HUMAN

Thyrotroph embryonic factor

0.382

NFIB_HUMAN

Nuclear factor 1 B-type

0.382

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.382

NFIA_HUMAN

Nuclear factor 1 A-type

0.382

FOXO1_HUMAN

Forkhead box protein O1

0.382

SEM5B_HUMAN

Semaphorin-5B

0.382

AP2A_HUMAN

Transcription factor AP-2-alpha

0.382

AP2B_HUMAN

Transcription factor AP-2-beta

0.382

TSN5_HUMAN

Tetraspanin-5

0.382

STON1_HUMAN

Stonin-1

0.382

CNTP1_HUMAN

Contactin-associated protein 1

0.386

RT30_HUMAN

39S ribosomal protein S30, mitochondrial

0.386

ONEC2_HUMAN

One cut domain family member 2

0.386

CNTP4_HUMAN

Contactin-associated protein-like 4

0.386

PEBB_HUMAN

Core-binding factor subunit beta

0.386

AHR_HUMAN

Aryl hydrocarbon receptor

0.386

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.386

ANLN_HUMAN

Anillin

0.386

NDUBA_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

0.386

RXRA_HUMAN

Retinoic acid receptor RXR-alpha

0.386

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.386

GO45_HUMAN

Golgin-45

0.386

AKA10_HUMAN

A-kinase anchor protein 10, mitochondrial

0.386

DLX1_HUMAN

Homeobox protein DLX-1

0.386

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.390

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.390

DAB2_HUMAN

Disabled homolog 2

0.390

MCF2L_HUMAN

Guanine nucleotide exchange factor DBS

0.390

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.390

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.390

HME2_HUMAN

Homeobox protein engrailed-2

0.390

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.390

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.390

TSHR_HUMAN

Thyrotropin receptor

0.390

RM51_HUMAN

39S ribosomal protein L51, mitochondrial

0.394

NEO1_HUMAN

Neogenin

0.394

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.394

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.394

GDF11_HUMAN

Growth/differentiation factor 11

0.394

PRRC1_HUMAN

Protein PRRC1

0.394

CTNL1_HUMAN

Alpha-catulin

0.394

LEG8_HUMAN

Galectin-8

0.394

PRD13_HUMAN

PR domain zinc finger protein 13

0.394

4ET_HUMAN

Eukaryotic translation initiation factor 4E transporter

0.399

PPM1H_HUMAN

Protein phosphatase 1H

0.399

FA20C_HUMAN

Extracellular serine/threonine protein kinase FAM20C

0.399

SATB1_HUMAN

DNA-binding protein SATB1

0.399

DCC_HUMAN

Netrin receptor DCC

0.399

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.399

FERM2_HUMAN

Fermitin family homolog 2

0.400

SYT1_HUMAN

Synaptotagmin-1

0.400

RUNX2_HUMAN

Runt-related transcription factor 2

0.400

FERM1_HUMAN

Fermitin family homolog 1

0.400

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.400

RHG10_HUMAN

Rho GTPase-activating protein 10

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.398

AT1B4_HUMAN

Protein ATP1B4

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 196 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy