RSPO2_HUMAN 2019

Gene Name RSPO2

Description R-spondin-2

Length 243

9606

Sequence

>sp|Q6UXX9|RSPO2_HUMAN R-spondin-2
MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQHSVFLATDRANQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

RSPO3_HUMAN

R-spondin-3

0.192

RSPO1_HUMAN

R-spondin-1

0.272

SLAI1_HUMAN

SLAIN motif-containing protein 1

0.385

AKNA_HUMAN

Microtubule organization protein AKNA

0.385

ZFAT_HUMAN

Zinc finger protein ZFAT

0.385

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RSPO1_HUMAN

R-spondin-1

0.280

ZFAT_HUMAN

Zinc finger protein ZFAT

0.310

RSPO3_HUMAN

R-spondin-3

0.340

SLAI1_HUMAN

SLAIN motif-containing protein 1

0.340

I17RA_HUMAN

Interleukin-17 receptor A

0.341

TXD16_HUMAN

Thioredoxin domain-containing protein 16

0.347

PRDM4_HUMAN

PR domain zinc finger protein 4

0.352

SLAI2_HUMAN

SLAIN motif-containing protein 2

0.354

TARSH_HUMAN

Target of Nesh-SH3

0.355

PDZ11_HUMAN

PDZ domain-containing protein 11

0.362

GAN_HUMAN

Gigaxonin

0.363

DBLOH_HUMAN

Diablo homolog, mitochondrial

0.363

AF1L2_HUMAN

Actin filament-associated protein 1-like 2

0.365

AF1L1_HUMAN

Actin filament-associated protein 1-like 1

0.365

MPP9_HUMAN

M-phase phosphoprotein 9

0.365

MATR3_HUMAN

Matrin-3

0.367

M3K14_HUMAN

Mitogen-activated protein kinase kinase kinase 14

0.367

GPBL1_HUMAN

Vasculin-like protein 1

0.367

I17RD_HUMAN

Interleukin-17 receptor D

0.367

F167A_HUMAN

Protein FAM167A

0.371

DRAXI_HUMAN

Draxin

0.372

RFLB_HUMAN

Refilin-B

0.372

NPAT_HUMAN

Protein NPAT

0.373

WDCP_HUMAN

WD repeat and coiled-coil-containing protein

0.373

CL029_HUMAN

Uncharacterized protein C12orf29

0.374

PCD20_HUMAN

Protocadherin-20

0.374

JMY_HUMAN

Junction-mediating and -regulatory protein

0.374

ZN366_HUMAN

Zinc finger protein 366

0.374

NXPE3_HUMAN

NXPE family member 3

0.376

TM196_HUMAN

Transmembrane protein 196

0.376

NODAL_HUMAN

Nodal homolog

0.376

CC181_HUMAN

Coiled-coil domain-containing protein 181

0.376

ZN451_HUMAN

E3 SUMO-protein ligase ZNF451

0.378

TR11B_HUMAN

Tumor necrosis factor receptor superfamily member 11B

0.378

GP173_HUMAN

Probable G-protein coupled receptor 173

0.378

CLN6_HUMAN

Ceroid-lipofuscinosis neuronal protein 6

0.378

NTF3_HUMAN

Neurotrophin-3

0.378

B2L13_HUMAN

Bcl-2-like protein 13

0.380

PANX1_HUMAN

Pannexin-1

0.380

ANKH_HUMAN

Progressive ankylosis protein homolog

0.380

ZBT44_HUMAN

Zinc finger and BTB domain-containing protein 44

0.382

STC2_HUMAN

Stanniocalcin-2

0.382

CC127_HUMAN

Coiled-coil domain-containing protein 127

0.382

ZN292_HUMAN

Zinc finger protein 292

0.382

CCG1_HUMAN

Voltage-dependent calcium channel gamma-1 subunit

0.382

CXAR_HUMAN

Coxsackievirus and adenovirus receptor

0.382

PANX3_HUMAN

Pannexin-3

0.382

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.383

CH034_HUMAN

Uncharacterized protein C8orf34

0.385

SCF_HUMAN

Kit ligand

0.385

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.385

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.387

FOXM1_HUMAN

Forkhead box protein M1

0.387

F199X_HUMAN

Protein FAM199X

0.387

POF1B_HUMAN

Protein POF1B

0.387

SLF2_HUMAN

SMC5-SMC6 complex localization factor protein 2

0.389

MYPN_HUMAN

Myopalladin

0.389

OTOL1_HUMAN

Otolin-1

0.390

TNR21_HUMAN

Tumor necrosis factor receptor superfamily member 21

0.390

AROS_HUMAN

Active regulator of SIRT1

0.390

CASC4_HUMAN

Protein CASC4

0.390

HAUS8_HUMAN

HAUS augmin-like complex subunit 8

0.390

WSB1_HUMAN

WD repeat and SOCS box-containing protein 1

0.391

PCDH9_HUMAN

Protocadherin-9

0.391

ZN507_HUMAN

Zinc finger protein 507

0.392

FNDC1_HUMAN

Fibronectin type III domain-containing protein 1

0.392

FANCC_HUMAN

Fanconi anemia group C protein

0.392

STC1_HUMAN

Stanniocalcin-1

0.392

IMPG2_HUMAN

Interphotoreceptor matrix proteoglycan 2

0.392

NET4_HUMAN

Netrin-4

0.392

K154L_HUMAN

UPF0606 protein KIAA1549L

0.392

HMGX3_HUMAN

HMG domain-containing protein 3

0.392

RFTN1_HUMAN

Raftlin

0.392

PRLR_HUMAN

Prolactin receptor

0.392

NEXN_HUMAN

Nexilin

0.392

SYNG1_HUMAN

Synapse differentiation-inducing gene protein 1

0.392

MTBP_HUMAN

Mdm2-binding protein

0.393

LRC42_HUMAN

Leucine-rich repeat-containing protein 42

0.393

ZN142_HUMAN

Zinc finger protein 142

0.394

PTN_HUMAN

Pleiotrophin

0.394

TPA_HUMAN

Tissue-type plasminogen activator

0.394

KLH42_HUMAN

Kelch-like protein 42

0.394

ZFP91_HUMAN

E3 ubiquitin-protein ligase ZFP91

0.394

TNFL6_HUMAN

Tumor necrosis factor ligand superfamily member 6

0.394

CRBA1_HUMAN

Beta-crystallin A3

0.394

GOLM1_HUMAN

Golgi membrane protein 1

0.394

CD166_HUMAN

CD166 antigen

0.394

NDP_HUMAN

Norrin

0.394

CR021_HUMAN

UPF0711 protein C18orf21

0.394

CCD80_HUMAN

Coiled-coil domain-containing protein 80

0.394

SNP47_HUMAN

Synaptosomal-associated protein 47

0.395

TGBR3_HUMAN

Transforming growth factor beta receptor type 3

0.395

GPR83_HUMAN

Probable G-protein coupled receptor 83

0.395

TEFF1_HUMAN

Tomoregulin-1

0.396

ZBTB1_HUMAN

Zinc finger and BTB domain-containing protein 1

0.396

NAIF1_HUMAN

Nuclear apoptosis-inducing factor 1

0.396

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.396

LUZP1_HUMAN

Leucine zipper protein 1

0.396

ZBT18_HUMAN

Zinc finger and BTB domain-containing protein 18

0.396

PTHR_HUMAN

Parathyroid hormone-related protein

0.396

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.396

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.396

ANGT_HUMAN

Angiotensinogen

0.396

ABEC2_HUMAN

C->U-editing enzyme APOBEC-2

0.396

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.396

HDX_HUMAN

Highly divergent homeobox

0.396

FPRP_HUMAN

Prostaglandin F2 receptor negative regulator

0.396

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.396

VCAM1_HUMAN

Vascular cell adhesion protein 1

0.396

CXCR4_HUMAN

C-X-C chemokine receptor type 4

0.396

ZN276_HUMAN

Zinc finger protein 276

0.396

CAD17_HUMAN

Cadherin-17

0.396

CCD18_HUMAN

Coiled-coil domain-containing protein 18

0.397

LBH_HUMAN

Protein LBH

0.398

ZBT24_HUMAN

Zinc finger and BTB domain-containing protein 24

0.398

DNER_HUMAN

Delta and Notch-like epidermal growth factor-related receptor

0.399

STEA2_HUMAN

Metalloreductase STEAP2

0.399

MYRIP_HUMAN

Rab effector MyRIP

0.399

RGCC_HUMAN

Regulator of cell cycle RGCC

0.400

EDAD_HUMAN

Ectodysplasin-A receptor-associated adapter protein

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 26 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy