K0408_HUMAN 2019

Gene Name K0408

Description Uncharacterized protein KIAA0408

Length 694

9606

Sequence

>sp|Q6ZU52|K0408_HUMAN Uncharacterized protein KIAA0408
MDLHKQWENTETNWHKEKMELLDQFDNERKEWESQWKIMQKKIEELCREVKLWRKININESAKIIDLYHEKTIPEKVIESSPNYPDLGQSEFIRTNHKDGLRKENKREQSLVSGGNQMCKEQKATKKSKVGFLDPLATDNQKECEAWPDLRTSEEDSKSCSGALSTALEELAKVSEELCSFQEEIRKRSNHRRMKSDSFLQEMPNVTNIPHGDPMINNDQCILPISLEKEKQKNRKNLSCTNVLQSNSTKKCGIDTIDLKRNETPPVPPPRSTSRNFPSSDSEQAYERWKERLDHNSWVPHEGRSKRNYNPHFPLRQQEMSMLYPNEGKTSKDGIIFSSLVPEVKIDSKPPSNEDVGLSMWSCDIGIGAKRSPSTSWFQKTCSTPSNPKYEMVIPDHPAKSHPDLHVSNDCSSSVAESSSPLRNFSCGFERTTRNEKLAAKTDEFNRTVFRTDRNCQAIQQNHSCSKSSEDLKPCDTSSTHTGSISQSNDVSGIWKTNAHMPVPMENVPDNPTKKSTTGLVRQMQGHLSPRSYRNMLHEHDWRPSNLSGRPRSADPRSNYGVVEKLLKTYETATESALQNSKCFQDNWTKCNSDVSGGATLSQHLEMLQMEQQFQQKTAVWGGQEVKQGIDPKKITEESMSVNASHGKGFSRPARPANRRLPSRWASRSPSAPPALRRTTHNYTISLRSEALMV

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

AMER3_HUMAN

APC membrane recruitment protein 3

0.365

IFNK_HUMAN

Interferon kappa

0.378

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.378

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

INGR2_HUMAN

Interferon gamma receptor 2

0.322

ZN326_HUMAN

DBIRD complex subunit ZNF326

0.331

SYT13_HUMAN

Synaptotagmin-13

0.331

SCG1_HUMAN

Secretogranin-1

0.333

CD47_HUMAN

Leukocyte surface antigen CD47

0.340

CF132_HUMAN

Uncharacterized protein C6orf132

0.340

BCAS1_HUMAN

Breast carcinoma-amplified sequence 1

0.340

IL23R_HUMAN

Interleukin-23 receptor

0.342

PDZD9_HUMAN

PDZ domain-containing protein 9

0.344

SMRP1_HUMAN

Spermatid-specific manchette-related protein 1

0.349

VTDB_HUMAN

Vitamin D-binding protein

0.351

UPK3A_HUMAN

Uroplakin-3a

0.356

LIF_HUMAN

Leukemia inhibitory factor

0.358

RAI3_HUMAN

Retinoic acid-induced protein 3

0.358

CA094_HUMAN

Uncharacterized protein C1orf94

0.360

CABYR_HUMAN

Calcium-binding tyrosine phosphorylation-regulated protein

0.360

SIAL_HUMAN

Bone sialoprotein 2

0.360

EXPH5_HUMAN

Exophilin-5

0.363

SNN_HUMAN

Stannin

0.364

PPR1C_HUMAN

Protein phosphatase 1 regulatory subunit 1C

0.364

TOX2_HUMAN

TOX high mobility group box family member 2

0.364

F1892_HUMAN

Protein FAM189A2

0.364

CD40L_HUMAN

CD40 ligand

0.369

SUSD4_HUMAN

Sushi domain-containing protein 4

0.369

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.369

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.369

INGR1_HUMAN

Interferon gamma receptor 1

0.371

LY86_HUMAN

Lymphocyte antigen 86

0.371

CLD16_HUMAN

Claudin-16

0.371

BPIB4_HUMAN

BPI fold-containing family B member 4

0.373

BID_HUMAN

BH3-interacting domain death agonist

0.373

CC110_HUMAN

Coiled-coil domain-containing protein 110

0.373

PPR17_HUMAN

Protein phosphatase 1 regulatory subunit 17

0.373

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.376

MALL_HUMAN

MAL-like protein

0.376

A1AG1_HUMAN

Alpha-1-acid glycoprotein 1

0.376

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.376

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.376

CKLF6_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 6

0.376

SNTAN_HUMAN

Sentan

0.376

ODFP1_HUMAN

Outer dense fiber protein 1

0.376

IL15_HUMAN

Interleukin-15

0.378

PDCD1_HUMAN

Programmed cell death protein 1

0.378

TM139_HUMAN

Transmembrane protein 139

0.378

CCD68_HUMAN

Coiled-coil domain-containing protein 68

0.378

OSTN_HUMAN

Osteocrin

0.378

EPCR_HUMAN

Endothelial protein C receptor

0.378

MB213_HUMAN

Protein mab-21-like 3

0.378

I22R2_HUMAN

Interleukin-22 receptor subunit alpha-2

0.378

PNOC_HUMAN

Prepronociceptin

0.378

IHO1_HUMAN

Interactor of HORMAD1 protein 1

0.380

PRD11_HUMAN

PR domain-containing protein 11

0.380

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.383

SPT16_HUMAN

Spermatogenesis-associated protein 16

0.385

ALBU_HUMAN

Serum albumin

0.385

RAMP2_HUMAN

Receptor activity-modifying protein 2

0.385

CDHR3_HUMAN

Cadherin-related family member 3

0.387

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.387

SHPS1_HUMAN

Tyrosine-protein phosphatase non-receptor type substrate 1

0.387

THY1_HUMAN

Thy-1 membrane glycoprotein

0.387

CLD18_HUMAN

Claudin-18

0.389

THMS1_HUMAN

Protein THEMIS

0.389

CTLA4_HUMAN

Cytotoxic T-lymphocyte protein 4

0.389

NEUT_HUMAN

Neurotensin/neuromedin N

0.389

ACRBP_HUMAN

Acrosin-binding protein

0.390

RESF1_HUMAN

Retroelement silencing factor 1

0.390

IL22_HUMAN

Interleukin-22

0.390

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.390

S10AB_HUMAN

Protein S100-A11

0.390

I22R1_HUMAN

Interleukin-22 receptor subunit alpha-1

0.390

ICOS_HUMAN

Inducible T-cell costimulator

0.392

PML_HUMAN

Protein PML

0.392

SPERT_HUMAN

Spermatid-associated protein

0.392

VEXIN_HUMAN

Vexin

0.392

ZN777_HUMAN

Zinc finger protein 777

0.392

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.393

LSME1_HUMAN

Leucine-rich single-pass membrane protein 1

0.395

UPKL2_HUMAN

Uroplakin-3b-like protein 2

0.395

GKN2_HUMAN

Gastrokine-2

0.395

IL9R_HUMAN

Interleukin-9 receptor

0.395

CL050_HUMAN

Uncharacterized protein C12orf50

0.395

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.396

CCGL_HUMAN

Voltage-dependent calcium channel gamma-like subunit

0.396

TRI29_HUMAN

Tripartite motif-containing protein 29

0.396

UPK1B_HUMAN

Uroplakin-1b

0.396

NANOG_HUMAN

Homeobox protein NANOG

0.396

RBM44_HUMAN

RNA-binding protein 44

0.398

IL18_HUMAN

Interleukin-18

0.398

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.398

CD2_HUMAN

T-cell surface antigen CD2

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 74 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy