PODN_HUMAN 2019

Gene Name PODN

Description Podocan

Length 613

9606

Sequence

>sp|Q7Z5L7|PODN_HUMAN Podocan
MAQSRVLLLLLLLPPQLHLGPVLAVRAPGFGRSGGHSLSPEENEFAEEEPVLVLSPEEPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGNLEFGDISKDRGRLGKEKEEEEEEEEEEEETR

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RGR_HUMAN

RPE-retinal G protein-coupled receptor

0.350

CA052_HUMAN

UPF0690 protein C1orf52

0.355

NFL_HUMAN

Neurofilament light polypeptide

0.362

FABP6_HUMAN

Gastrotropin

0.362

STC2_HUMAN

Stanniocalcin-2

0.362

STXB6_HUMAN

Syntaxin-binding protein 6

0.362

PCOC2_HUMAN

Procollagen C-endopeptidase enhancer 2

0.362

SH3B4_HUMAN

SH3 domain-binding protein 4

0.362

BORG2_HUMAN

Cdc42 effector protein 3

0.362

STYK1_HUMAN

Tyrosine-protein kinase STYK1

0.364

ASTN1_HUMAN

Astrotactin-1

0.364

NET4_HUMAN

Netrin-4

0.374

STC1_HUMAN

Stanniocalcin-1

0.374

ZN142_HUMAN

Zinc finger protein 142

0.376

MACC1_HUMAN

Metastasis-associated in colon cancer protein 1

0.376

FBLN7_HUMAN

Fibulin-7

0.376

CD166_HUMAN

CD166 antigen

0.376

TSN18_HUMAN

Tetraspanin-18

0.376

MC4R_HUMAN

Melanocortin receptor 4

0.376

CEP55_HUMAN

Centrosomal protein of 55 kDa

0.376

TSN12_HUMAN

Tetraspanin-12

0.376

ZN335_HUMAN

Zinc finger protein 335

0.378

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.378

CCR7_HUMAN

C-C chemokine receptor type 7

0.378

LYRIC_HUMAN

Protein LYRIC

0.378

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.378

RAB12_HUMAN

Ras-related protein Rab-12

0.378

FMOD_HUMAN

Fibromodulin

0.378

MUC18_HUMAN

Cell surface glycoprotein MUC18

0.378

CLD11_HUMAN

Claudin-11

0.378

SCG3_HUMAN

Secretogranin-3

0.378

CXD2_HUMAN

Gap junction delta-2 protein

0.378

LRC52_HUMAN

Leucine-rich repeat-containing protein 52

0.378

CCSE1_HUMAN

Serine-rich coiled-coil domain-containing protein 1

0.380

PCD10_HUMAN

Protocadherin-10

0.380

ZN711_HUMAN

Zinc finger protein 711

0.380

OGR1_HUMAN

Ovarian cancer G-protein coupled receptor 1

0.380

SYNCI_HUMAN

Syncoilin

0.380

ESM1_HUMAN

Endothelial cell-specific molecule 1

0.380

GPC5B_HUMAN

G-protein coupled receptor family C group 5 member B

0.380

PCD12_HUMAN

Protocadherin-12

0.382

LPAR1_HUMAN

Lysophosphatidic acid receptor 1

0.385

ZBT37_HUMAN

Zinc finger and BTB domain-containing protein 37

0.385

NECT3_HUMAN

Nectin-3

0.387

CXB1_HUMAN

Gap junction beta-1 protein

0.387

CC127_HUMAN

Coiled-coil domain-containing protein 127

0.387

RIC3_HUMAN

Protein RIC-3

0.387

LFTY2_HUMAN

Left-right determination factor 2

0.387

CXAR_HUMAN

Coxsackievirus and adenovirus receptor

0.387

EURL_HUMAN

Protein EURL homolog

0.387

GAK1B_HUMAN

Golgi-associated kinase 1B

0.387

OCLN_HUMAN

Occludin

0.389

PENK_HUMAN

Proenkephalin-A

0.389

CBLN4_HUMAN

Cerebellin-4

0.389

CRBB1_HUMAN

Beta-crystallin B1

0.389

S1PR3_HUMAN

Sphingosine 1-phosphate receptor 3

0.389

LARGN_HUMAN

Protein Largen

0.389

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.389

CALD1_HUMAN

Caldesmon

0.389

MYPC3_HUMAN

Myosin-binding protein C, cardiac-type

0.389

PDGFC_HUMAN

Platelet-derived growth factor C

0.389

FAKD2_HUMAN

FAST kinase domain-containing protein 2, mitochondrial

0.389

NPY_HUMAN

Pro-neuropeptide Y

0.389

ZN131_HUMAN

Zinc finger protein 131

0.389

NEXMI_HUMAN

Neurite extension and migration factor

0.389

MERB1_HUMAN

bMERB domain-containing protein 1

0.389

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.389

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.389

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.389

GHR_HUMAN

Growth hormone receptor

0.389

SYBU_HUMAN

Syntabulin

0.389

JAM3_HUMAN

Junctional adhesion molecule C

0.389

MYZAP_HUMAN

Myocardial zonula adherens protein

0.389

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.389

LEG1_HUMAN

Galectin-1

0.389

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.389

ZN644_HUMAN

Zinc finger protein 644

0.389

PRL_HUMAN

Prolactin

0.389

CO7_HUMAN

Complement component C7

0.389

F131A_HUMAN

Protein FAM131A

0.391

FETUB_HUMAN

Fetuin-B

0.391

CC126_HUMAN

Coiled-coil domain-containing protein 126

0.391

SCN3B_HUMAN

Sodium channel subunit beta-3

0.391

ZN652_HUMAN

Zinc finger protein 652

0.391

TM182_HUMAN

Transmembrane protein 182

0.391

TSN1_HUMAN

Tetraspanin-1

0.391

ERRFI_HUMAN

ERBB receptor feedback inhibitor 1

0.391

F222B_HUMAN

Protein FAM222B

0.391

CAVN2_HUMAN

Caveolae-associated protein 2

0.391

F163B_HUMAN

Protein FAM163B

0.391

EVPL_HUMAN

Envoplakin

0.391

MIME_HUMAN

Mimecan

0.391

PEPL_HUMAN

Periplakin

0.391

SLIK1_HUMAN

SLIT and NTRK-like protein 1

0.391

DLK2_HUMAN

Protein delta homolog 2

0.391

GDF9_HUMAN

Growth/differentiation factor 9

0.391

BAG5_HUMAN

BAG family molecular chaperone regulator 5

0.391

ZN148_HUMAN

Zinc finger protein 148

0.391

ZBT20_HUMAN

Zinc finger and BTB domain-containing protein 20

0.391

HBEGF_HUMAN

Proheparin-binding EGF-like growth factor

0.391

CHP3_HUMAN

Calcineurin B homologous protein 3

0.393

BRI3B_HUMAN

BRI3-binding protein

0.393

NRN1_HUMAN

Neuritin

0.393

LRC38_HUMAN

Leucine-rich repeat-containing protein 38

0.393

F171B_HUMAN

Protein FAM171B

0.393

TRADD_HUMAN

Tumor necrosis factor receptor type 1-associated DEATH domain protein

0.393

KCMB2_HUMAN

Calcium-activated potassium channel subunit beta-2

0.396

FLIP1_HUMAN

Filamin-A-interacting protein 1

0.396

MASP1_HUMAN

Mannan-binding lectin serine protease 1

0.396

PCD18_HUMAN

Protocadherin-18

0.396

AKIP_HUMAN

Aurora kinase A-interacting protein

0.397

IBP5_HUMAN

Insulin-like growth factor-binding protein 5

0.398

IMPG2_HUMAN

Interphotoreceptor matrix proteoglycan 2

0.398

NEXN_HUMAN

Nexilin

0.398

NECT1_HUMAN

Nectin-1

0.398

PRLR_HUMAN

Prolactin receptor

0.398

DKK2_HUMAN

Dickkopf-related protein 2

0.398

FLRT2_HUMAN

Leucine-rich repeat transmembrane protein FLRT2

0.398

T150A_HUMAN

Transmembrane protein 150A

0.400

KLH42_HUMAN

Kelch-like protein 42

0.400

CRBA1_HUMAN

Beta-crystallin A3

0.400

VTNC_HUMAN

Vitronectin

0.400

MYPC1_HUMAN

Myosin-binding protein C, slow-type

0.400

ZBT34_HUMAN

Zinc finger and BTB domain-containing protein 34

0.400

LFTY1_HUMAN

Left-right determination factor 1

0.400

CXG1_HUMAN

Gap junction gamma-1 protein

0.400

PROS_HUMAN

Vitamin K-dependent protein S

0.400

ASB4_HUMAN

Ankyrin repeat and SOCS box protein 4

0.400

IKZF2_HUMAN

Zinc finger protein Helios

0.400

CCD80_HUMAN

Coiled-coil domain-containing protein 80

0.400

PTN_HUMAN

Pleiotrophin

0.400

TPA_HUMAN

Tissue-type plasminogen activator

0.400

GCR_HUMAN

Glucocorticoid receptor

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 19 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy