KCD20_HUMAN 2019

Gene Name KCD20

Description BTB/POZ domain-containing protein KCTD20

Length 419

9606

Sequence

>sp|Q7Z5Y7|KCD20_HUMAN BTB/POZ domain-containing protein KCTD20
MNVHRGSDSDRLLRQEASCLVDDTLAVAQEKEANSLASSGPHNLTYPLGPRNEDLSLDYASQPANLQFPHIMPLAEDIKGSCFQSGNKRNHEPFIAPERFGNSSVGFGSNSHSQAPEKVTLLVDGTRFVVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISATVFRTVLDYYKTGIINCPDGISIPDLRDTCDYLCINFDFNTIRCQDLSALLHELSNDGAHKQFDHYLEELILPIMVGCAKKGERECHIVVLTDEDSVDWDEDHPPPMGEEYSQILYSSKLYRFFKYIENRDVAKTVLKERGLKNIRIGIEGYPTCKEKIKRRPGGRSEVIYNYVQRPFIQMSWEKEEGKSRHVDFQCVRSKSLTNLVAAGDDVLEDQEILMHHPPQVDELDRLNAPLSQMASNDFQD

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.313

MTCH1_HUMAN

Mitochondrial carrier homolog 1

0.326

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.367

ARFP1_HUMAN

Arfaptin-1

0.367

PROM2_HUMAN

Prominin-2

0.386

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.389

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.392

ARRB2_HUMAN

Beta-arrestin-2

0.392

WDFY1_HUMAN

WD repeat and FYVE domain-containing protein 1

0.392

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.396

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.396

CREL2_HUMAN

Cysteine-rich with EGF-like domain protein 2

0.396

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.292

MTCH1_HUMAN

Mitochondrial carrier homolog 1

0.328

STON2_HUMAN

Stonin-2

0.347

LIPA4_HUMAN

Liprin-alpha-4

0.354

CCND3_HUMAN

G1/S-specific cyclin-D3

0.356

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.367

ERG_HUMAN

Transcriptional regulator ERG

0.369

SLIT3_HUMAN

Slit homolog 3 protein

0.369

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.370

PROM2_HUMAN

Prominin-2

0.371

CBLB_HUMAN

E3 ubiquitin-protein ligase CBL-B

0.371

SHC4_HUMAN

SHC-transforming protein 4

0.372

EZRI_HUMAN

Ezrin

0.373

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.373

RUNX1_HUMAN

Runt-related transcription factor 1

0.374

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.375

CHIC2_HUMAN

Cysteine-rich hydrophobic domain-containing protein 2

0.377

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.379

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.381

ARFP1_HUMAN

Arfaptin-1

0.381

TNIK_HUMAN

TRAF2 and NCK-interacting protein kinase

0.382

MYL1_HUMAN

Myosin light chain 1/3, skeletal muscle isoform

0.383

FA76A_HUMAN

Protein FAM76A

0.384

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.384

ARRB1_HUMAN

Beta-arrestin-1

0.386

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.387

PICK1_HUMAN

PRKCA-binding protein

0.387

NOTC2_HUMAN

Neurogenic locus notch homolog protein 2

0.387

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.388

LMBL2_HUMAN

Lethal(3)malignant brain tumor-like protein 2

0.389

BACD2_HUMAN

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

0.390

TPST2_HUMAN

Protein-tyrosine sulfotransferase 2

0.390

ITB1_HUMAN

Integrin beta-1

0.390

PCX1_HUMAN

Pecanex-like protein 1

0.391

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.392

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.392

TAOK3_HUMAN

Serine/threonine-protein kinase TAO3

0.392

HDC_HUMAN

Headcase protein homolog

0.393

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.393

WLS_HUMAN

Protein wntless homolog

0.393

ELF1_HUMAN

ETS-related transcription factor Elf-1

0.393

MIGA1_HUMAN

Mitoguardin 1

0.394

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.395

FEM1C_HUMAN

Protein fem-1 homolog C

0.396

AP2B_HUMAN

Transcription factor AP-2-beta

0.396

SNRK_HUMAN

SNF-related serine/threonine-protein kinase

0.396

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.397

BMP2_HUMAN

Bone morphogenetic protein 2

0.397

MAGI3_HUMAN

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

0.397

WDFY1_HUMAN

WD repeat and FYVE domain-containing protein 1

0.398

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.398

PLXA2_HUMAN

Plexin-A2

0.398

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.398

AT1B4_HUMAN

Protein ATP1B4

0.398

MIGA2_HUMAN

Mitoguardin 2

0.398

NEMP2_HUMAN

Nuclear envelope integral membrane protein 2

0.399

UBN1_HUMAN

Ubinuclein-1

0.399

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.399

RT22_HUMAN

28S ribosomal protein S22, mitochondrial

0.399

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 46 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy