LRRT1_HUMAN 2019

Gene Name LRRT1

Description Leucine-rich repeat transmembrane neuronal protein 1

Length 522

9606

Sequence

>sp|Q86UE6|LRRT1_HUMAN Leucine-rich repeat transmembrane neuronal protein 1
MDFLLLGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHAENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

HDX_HUMAN

Highly divergent homeobox

0.295

MREG_HUMAN

Melanoregulin

0.295

PRDM2_HUMAN

PR domain zinc finger protein 2

0.295

LR75A_HUMAN

Leucine-rich repeat-containing protein 75A

0.295

LRRT4_HUMAN

Leucine-rich repeat transmembrane neuronal protein 4

0.295

DRAXI_HUMAN

Draxin

0.295

CC127_HUMAN

Coiled-coil domain-containing protein 127

0.295

GPR61_HUMAN

G-protein coupled receptor 61

0.295

KBTB2_HUMAN

Kelch repeat and BTB domain-containing protein 2

0.346

GEMI4_HUMAN

Gem-associated protein 4

0.354

LFTY2_HUMAN

Left-right determination factor 2

0.354

K154L_HUMAN

UPF0606 protein KIAA1549L

0.354

T126A_HUMAN

Transmembrane protein 126A

0.354

NPNT_HUMAN

Nephronectin

0.354

THSD1_HUMAN

Thrombospondin type-1 domain-containing protein 1

0.354

HNMT_HUMAN

Histamine N-methyltransferase

0.354

PKR2_HUMAN

Prokineticin receptor 2

0.354

OTOL1_HUMAN

Otolin-1

0.354

LFTY1_HUMAN

Left-right determination factor 1

0.354

AKAP6_HUMAN

A-kinase anchor protein 6

0.354

EGFL6_HUMAN

Epidermal growth factor-like protein 6

0.354

RET4_HUMAN

Retinol-binding protein 4

0.354

DKK2_HUMAN

Dickkopf-related protein 2

0.354

PTN_HUMAN

Pleiotrophin

0.361

GAK1B_HUMAN

Golgi-associated kinase 1B

0.361

T255A_HUMAN

Transmembrane protein 255A

0.361

RLF_HUMAN

Zinc finger protein Rlf

0.361

CRBA1_HUMAN

Beta-crystallin A3

0.361

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.361

RFXAP_HUMAN

Regulatory factor X-associated protein

0.361

SMI19_HUMAN

Small integral membrane protein 19

0.361

PRLR_HUMAN

Prolactin receptor

0.361

TPA_HUMAN

Tissue-type plasminogen activator

0.361

PRLHR_HUMAN

Prolactin-releasing peptide receptor

0.361

EDNRB_HUMAN

Endothelin receptor type B

0.361

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.361

I10R2_HUMAN

Interleukin-10 receptor subunit beta

0.361

RAMP3_HUMAN

Receptor activity-modifying protein 3

0.361

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.361

CJ088_HUMAN

Uncharacterized protein C10orf88

0.361

TSN18_HUMAN

Tetraspanin-18

0.361

GP153_HUMAN

Probable G-protein coupled receptor 153

0.361

EFCC1_HUMAN

EF-hand and coiled-coil domain-containing protein 1

0.361

SCG3_HUMAN

Secretogranin-3

0.361

PGBD5_HUMAN

PiggyBac transposable element-derived protein 5

0.361

FANCC_HUMAN

Fanconi anemia group C protein

0.361

IMPG2_HUMAN

Interphotoreceptor matrix proteoglycan 2

0.361

KNL1_HUMAN

Kinetochore scaffold 1

0.361

LARGN_HUMAN

Protein Largen

0.361

CCDC3_HUMAN

Coiled-coil domain-containing protein 3

0.361

HBAZ_HUMAN

Hemoglobin subunit zeta

0.361

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.361

C2C4C_HUMAN

C2 calcium-dependent domain-containing protein 4C

0.361

PKR1_HUMAN

Prokineticin receptor 1

0.361

UR2R_HUMAN

Urotensin-2 receptor

0.361

EURL_HUMAN

Protein EURL homolog

0.361

ZN148_HUMAN

Zinc finger protein 148

0.361

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.361

EDNRA_HUMAN

Endothelin-1 receptor

0.361

RET2_HUMAN

Retinol-binding protein 2

0.361

LYAM3_HUMAN

P-selectin

0.400

ANKH_HUMAN

Progressive ankylosis protein homolog

0.400

ASB7_HUMAN

Ankyrin repeat and SOCS box protein 7

0.400

IL6RB_HUMAN

Interleukin-6 receptor subunit beta

0.400

SLF2_HUMAN

SMC5-SMC6 complex localization factor protein 2

0.400

CTHR1_HUMAN

Collagen triple helix repeat-containing protein 1

0.400

NXPE3_HUMAN

NXPE family member 3

0.400

FNDC1_HUMAN

Fibronectin type III domain-containing protein 1

0.400

NTF3_HUMAN

Neurotrophin-3

0.400

BOREA_HUMAN

Borealin

0.400

TSN15_HUMAN

Tetraspanin-15

0.400

SIMC1_HUMAN

SUMO-interacting motif-containing protein 1

0.400

SNX10_HUMAN

Sorting nexin-10

0.400

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.400

NGF_HUMAN

Beta-nerve growth factor

0.400

FANCB_HUMAN

Fanconi anemia group B protein

0.400

LIFR_HUMAN

Leukemia inhibitory factor receptor

0.400

HRH2_HUMAN

Histamine H2 receptor

0.400

KTBL1_HUMAN

KATNB1-like protein 1

0.400

GFRA1_HUMAN

GDNF family receptor alpha-1

0.400

SLAI2_HUMAN

SLAIN motif-containing protein 2

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

PRDM2_HUMAN

PR domain zinc finger protein 2

0.362

LRRT4_HUMAN

Leucine-rich repeat transmembrane neuronal protein 4

0.362

GAK1B_HUMAN

Golgi-associated kinase 1B

0.364

BAG5_HUMAN

BAG family molecular chaperone regulator 5

0.368

CD276_HUMAN

CD276 antigen

0.368

F163B_HUMAN

Protein FAM163B

0.368

HNMT_HUMAN

Histamine N-methyltransferase

0.374

RET4_HUMAN

Retinol-binding protein 4

0.374

NHLC3_HUMAN

NHL repeat-containing protein 3

0.374

PRLR_HUMAN

Prolactin receptor

0.376

DRAXI_HUMAN

Draxin

0.380

HDX_HUMAN

Highly divergent homeobox

0.380

F1711_HUMAN

Protein FAM171A1

0.380

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.380

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.380

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.380

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.380

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.380

ANGT_HUMAN

Angiotensinogen

0.380

CXL14_HUMAN

C-X-C motif chemokine 14

0.382

GP149_HUMAN

Probable G-protein coupled receptor 149

0.382

PTGDS_HUMAN

Prostaglandin-H2 D-isomerase

0.384

TARSH_HUMAN

Target of Nesh-SH3

0.387

ANKH_HUMAN

Progressive ankylosis protein homolog

0.387

CC127_HUMAN

Coiled-coil domain-containing protein 127

0.389

CXAR_HUMAN

Coxsackievirus and adenovirus receptor

0.389

LFTY2_HUMAN

Left-right determination factor 2

0.389

EURL_HUMAN

Protein EURL homolog

0.389

STC2_HUMAN

Stanniocalcin-2

0.389

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.391

LARGN_HUMAN

Protein Largen

0.391

BEND7_HUMAN

BEN domain-containing protein 7

0.391

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.391

ZN131_HUMAN

Zinc finger protein 131

0.391

MYZAP_HUMAN

Myocardial zonula adherens protein

0.391

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.391

NEXMI_HUMAN

Neurite extension and migration factor

0.391

CDHR1_HUMAN

Cadherin-related family member 1

0.391

TM263_HUMAN

Transmembrane protein 263

0.391

OCLN_HUMAN

Occludin

0.391

SYBU_HUMAN

Syntabulin

0.391

PDGFC_HUMAN

Platelet-derived growth factor C

0.391

NHSL1_HUMAN

NHS-like protein 1

0.391

NPY_HUMAN

Pro-neuropeptide Y

0.391

ASTN1_HUMAN

Astrotactin-1

0.391

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.391

CFLAR_HUMAN

CASP8 and FADD-like apoptosis regulator

0.391

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.391

PRL_HUMAN

Prolactin

0.391

LEG1_HUMAN

Galectin-1

0.391

PENK_HUMAN

Proenkephalin-A

0.391

SGO1_HUMAN

Shugoshin 1

0.391

MERB1_HUMAN

bMERB domain-containing protein 1

0.391

GHR_HUMAN

Growth hormone receptor

0.391

ZN644_HUMAN

Zinc finger protein 644

0.391

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.391

RLF_HUMAN

Zinc finger protein Rlf

0.391

MRAP2_HUMAN

Melanocortin-2 receptor accessory protein 2

0.393

SCN3B_HUMAN

Sodium channel subunit beta-3

0.393

ZN148_HUMAN

Zinc finger protein 148

0.393

ZN652_HUMAN

Zinc finger protein 652

0.393

F168B_HUMAN

Myelin-associated neurite-outgrowth inhibitor

0.393

BSPRY_HUMAN

B box and SPRY domain-containing protein

0.393

GP176_HUMAN

G-protein coupled receptor 176

0.393

EVPL_HUMAN

Envoplakin

0.393

TR150_HUMAN

Thyroid hormone receptor-associated protein 3

0.393

NUFP2_HUMAN

Nuclear fragile X mental retardation-interacting protein 2

0.393

F168A_HUMAN

Protein FAM168A

0.393

CMGA_HUMAN

Chromogranin-A

0.393

CCPG1_HUMAN

Cell cycle progression protein 1

0.393

SYNEM_HUMAN

Synemin

0.393

FNDC7_HUMAN

Fibronectin type III domain-containing protein 7

0.393

EMIL2_HUMAN

EMILIN-2

0.395

SLAP1_HUMAN

Src-like-adapter

0.395

FA83H_HUMAN

Protein FAM83H

0.395

MYCT1_HUMAN

Myc target protein 1

0.395

ANGL3_HUMAN

Angiopoietin-related protein 3

0.395

GP183_HUMAN

G-protein coupled receptor 183

0.397

CITE2_HUMAN

Cbp/p300-interacting transactivator 2

0.397

MATR3_HUMAN

Matrin-3

0.398

GPBL1_HUMAN

Vasculin-like protein 1

0.398

AROS_HUMAN

Active regulator of SIRT1

0.398

DKK2_HUMAN

Dickkopf-related protein 2

0.400

HMGX3_HUMAN

HMG domain-containing protein 3

0.400

AKAP6_HUMAN

A-kinase anchor protein 6

0.400

STC1_HUMAN

Stanniocalcin-1

0.400

FNDC1_HUMAN

Fibronectin type III domain-containing protein 1

0.400

NET4_HUMAN

Netrin-4

0.400

FANCC_HUMAN

Fanconi anemia group C protein

0.400

K154L_HUMAN

UPF0606 protein KIAA1549L

0.400

SYNG1_HUMAN

Synapse differentiation-inducing gene protein 1

0.400

IMPG2_HUMAN

Interphotoreceptor matrix proteoglycan 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 22 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy