HPS6_HUMAN 2019

Gene Name HPS6

Description Hermansky-Pudlak syndrome 6 protein

Length 775

9606

Sequence

>sp|Q86YV9|HPS6_HUMAN Hermansky-Pudlak syndrome 6 protein
MKRSGTLRLLSDLSAFGGAARLRELVAGDSAVRVRGSPDGRHLLLLRPPGAVAPQLLVASRGPGAELERAWPAGQPSPLDAFFLPWPARPALVLVWESGLAEVWGAGVGPGWRPLQSTELCPGGGARVVAVAALRGRLVWCEERQARAEGPSGSPAAAFSHCVCVRTLEPSGEASTSLGRTHVLLHHCPAFGLLASCRQLFLVPTATTWPGVAHVLLIWSPGKGKVMVAAPRLGLSYSKSLNPGRGDTWDFRTLLRGLPGLLSPREPLAVHTWAPTPQGLLLLDFGGTVSLLQSHGGTRAVGTLQEAPVGPWGSAALGTFQGTLACVLGSTLELLDMGSGQLLERKVLSTDRVHLLEPPAPGMEDEEELETRGNLRLLSALGLFCVGWEAPQGVELPSAKDLVFEEACGYYQRRSLRGAQLTPEELRHSSTFRAPQALASILQGHLPPSALLTMLRTELRDYRGLEQLKAQLVAGDDEEAGWTELAEQEVARLLRTELIGDQLAQLNTVFQALPTAAWGATLRALQLQLDGNGKLRSQAPPDVWKKVLGGITAGKEPPNGILPPFELLCQCLCQLEPRWLPPFVELAQQQGGPGWGAGGPGLPLYRRALAVLGEEGTRPEALELELLLSSGRPKAVLQAVGQLVQKEQWDRALDAGLALGPSSPLLRSEIFKLLLAEFAQHRRLDAHLPLLCRLCPPELAPAELLLLLRTYLPDEVGPPTPFPEPGAEPPLTVGLLKALLEQTGAQGWLSGPVLSPYEDILWDPSTPPPTPPRDL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

INSY1_HUMAN

Inhibitory synaptic factor 1

0.324

CD276_HUMAN

CD276 antigen

0.324

ASTN2_HUMAN

Astrotactin-2

0.324

SOCS3_HUMAN

Suppressor of cytokine signaling 3

0.324

SOGA1_HUMAN

Protein SOGA1

0.324

SHL2A_HUMAN

Protein shisa-like-2A

0.324

RAMP1_HUMAN

Receptor activity-modifying protein 1

0.324

PRDM6_HUMAN

Putative histone-lysine N-methyltransferase PRDM6

0.324

PMEL_HUMAN

Melanocyte protein PMEL

0.333

THMS2_HUMAN

Protein THEMIS2

0.333

CD3D_HUMAN

T-cell surface glycoprotein CD3 delta chain

0.333

GAK1B_HUMAN

Golgi-associated kinase 1B

0.387

PGBD5_HUMAN

PiggyBac transposable element-derived protein 5

0.387

F181A_HUMAN

Protein FAM181A

0.387

RAMP3_HUMAN

Receptor activity-modifying protein 3

0.387

PRLR_HUMAN

Prolactin receptor

0.387

RET2_HUMAN

Retinol-binding protein 2

0.387

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.387

CCDC3_HUMAN

Coiled-coil domain-containing protein 3

0.387

T255A_HUMAN

Transmembrane protein 255A

0.387

HBAZ_HUMAN

Hemoglobin subunit zeta

0.387

PTN_HUMAN

Pleiotrophin

0.387

LARGN_HUMAN

Protein Largen

0.387

ZN148_HUMAN

Zinc finger protein 148

0.387

PKR1_HUMAN

Prokineticin receptor 1

0.387

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.387

PRLHR_HUMAN

Prolactin-releasing peptide receptor

0.387

TPA_HUMAN

Tissue-type plasminogen activator

0.387

NR0B1_HUMAN

Nuclear receptor subfamily 0 group B member 1

0.387

EFCC1_HUMAN

EF-hand and coiled-coil domain-containing protein 1

0.387

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.387

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.387

HPLN4_HUMAN

Hyaluronan and proteoglycan link protein 4

0.387

EURL_HUMAN

Protein EURL homolog

0.387

ZHX2_HUMAN

Zinc fingers and homeoboxes protein 2

0.387

EDNRB_HUMAN

Endothelin receptor type B

0.387

SCG3_HUMAN

Secretogranin-3

0.387

RFXAP_HUMAN

Regulatory factor X-associated protein

0.387

TSN18_HUMAN

Tetraspanin-18

0.387

EDNRA_HUMAN

Endothelin-1 receptor

0.387

I10R2_HUMAN

Interleukin-10 receptor subunit beta

0.387

CRBA1_HUMAN

Beta-crystallin A3

0.387

C2C4C_HUMAN

C2 calcium-dependent domain-containing protein 4C

0.387

RLF_HUMAN

Zinc finger protein Rlf

0.387

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.387

DSG2_HUMAN

Desmoglein-2

0.397

K2C8_HUMAN

Keratin, type II cytoskeletal 8

0.397

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.397

HEG1_HUMAN

Protein HEG homolog 1

0.397

RHNO1_HUMAN

RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

0.397

ARTN_HUMAN

Artemin

0.397

SOMA_HUMAN

Somatotropin

0.397

NMI_HUMAN

N-myc-interactor

0.397

CSH2_HUMAN

Chorionic somatomammotropin hormone 2

0.397

ZN217_HUMAN

Zinc finger protein 217

0.397

SOM2_HUMAN

Growth hormone variant

0.397

MPZL1_HUMAN

Myelin protein zero-like protein 1

0.397

TM240_HUMAN

Transmembrane protein 240

0.397

CD3G_HUMAN

T-cell surface glycoprotein CD3 gamma chain

0.397

TOR4A_HUMAN

Torsin-4A

0.397

HECA2_HUMAN

HEPACAM family member 2

0.397

FETUB_HUMAN

Fetuin-B

0.397

PRR35_HUMAN

Proline-rich protein 35

0.397

K1C18_HUMAN

Keratin, type I cytoskeletal 18

0.397

IL2RG_HUMAN

Cytokine receptor common subunit gamma

0.397

GP149_HUMAN

Probable G-protein coupled receptor 149

0.397

CNRG_HUMAN

Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.397

CRBA2_HUMAN

Beta-crystallin A2

0.397

ZN319_HUMAN

Zinc finger protein 319

0.397

ZBTB5_HUMAN

Zinc finger and BTB domain-containing protein 5

0.397

HXC13_HUMAN

Homeobox protein Hox-C13

0.397

BTC_HUMAN

Probetacellulin

0.397

FA83C_HUMAN

Protein FAM83C

0.397

CHP3_HUMAN

Calcineurin B homologous protein 3

0.397

NHLC1_HUMAN

E3 ubiquitin-protein ligase NHLRC1

0.397

PTGDS_HUMAN

Prostaglandin-H2 D-isomerase

0.397

CART_HUMAN

Cocaine- and amphetamine-regulated transcript protein

0.397

CSH1_HUMAN

Chorionic somatomammotropin hormone 1

0.397

CQ058_HUMAN

UPF0450 protein C17orf58

0.397

TMG4_HUMAN

Transmembrane gamma-carboxyglutamic acid protein 4

0.397

ARMX1_HUMAN

Armadillo repeat-containing X-linked protein 1

0.397

CX021_HUMAN

Uncharacterized protein CXorf21

0.397

CC152_HUMAN

Coiled-coil domain-containing protein 152

0.397

CML1_HUMAN

Chemokine-like receptor 1

0.397

CK2N2_HUMAN

Calcium/calmodulin-dependent protein kinase II inhibitor 2

0.397

UIMC1_HUMAN

BRCA1-A complex subunit RAP80

0.397

BT1A1_HUMAN

Butyrophilin subfamily 1 member A1

0.397

EVPL_HUMAN

Envoplakin

0.397

INHA_HUMAN

Inhibin alpha chain

0.397

VTM2L_HUMAN

V-set and transmembrane domain-containing protein 2-like protein

0.397

CALC_HUMAN

Calcitonin

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CX021_HUMAN

Uncharacterized protein CXorf21

0.382

P2RY6_HUMAN

P2Y purinoceptor 6

0.382

LARGN_HUMAN

Protein Largen

0.390

CRBB1_HUMAN

Beta-crystallin B1

0.390

ZN148_HUMAN

Zinc finger protein 148

0.392

PTAFR_HUMAN

Platelet-activating factor receptor

0.397

CLD8_HUMAN

Claudin-8

0.397

GPR55_HUMAN

G-protein coupled receptor 55

0.399

SYNG1_HUMAN

Synapse differentiation-inducing gene protein 1

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 79 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy