NPAS4_HUMAN 2019

Gene Name NPAS4

Description Neuronal PAS domain-containing protein 4

Length 802

9606

Sequence

>sp|Q8IUM7|NPAS4_HUMAN Neuronal PAS domain-containing protein 4
MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLEPLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTPDPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDELHQLQSQVQDSFHEDGSGGEPTF

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SALL1_HUMAN

Sal-like protein 1

0.312

LEG8_HUMAN

Galectin-8

0.312

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.312

TUTLB_HUMAN

Protein turtle homolog B

0.316

DCC_HUMAN

Netrin receptor DCC

0.316

ACM3_HUMAN

Muscarinic acetylcholine receptor M3

0.341

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.341

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.341

CEBPG_HUMAN

CCAAT/enhancer-binding protein gamma

0.341

TMCC3_HUMAN

Transmembrane and coiled-coil domain protein 3

0.345

CELR1_HUMAN

Cadherin EGF LAG seven-pass G-type receptor 1

0.345

NEGR1_HUMAN

Neuronal growth regulator 1

0.345

IGLO5_HUMAN

IgLON family member 5

0.349

TMCC2_HUMAN

Transmembrane and coiled-coil domains protein 2

0.349

CDX2_HUMAN

Homeobox protein CDX-2

0.358

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.369

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.369

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.374

HME2_HUMAN

Homeobox protein engrailed-2

0.374

MED24_HUMAN

Mediator of RNA polymerase II transcription subunit 24

0.374

SKT_HUMAN

Sickle tail protein homolog

0.374

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.374

NAB1_HUMAN

NGFI-A-binding protein 1

0.374

NR2C1_HUMAN

Nuclear receptor subfamily 2 group C member 1

0.374

CELR3_HUMAN

Cadherin EGF LAG seven-pass G-type receptor 3

0.374

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein

0.374

EFNB1_HUMAN

Ephrin-B1

0.378

SPDEF_HUMAN

SAM pointed domain-containing Ets transcription factor

0.378

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.378

NEO1_HUMAN

Neogenin

0.378

TMCC1_HUMAN

Transmembrane and coiled-coil domains protein 1

0.378

AMOT_HUMAN

Angiomotin

0.378

CTNL1_HUMAN

Alpha-catulin

0.378

GDF11_HUMAN

Growth/differentiation factor 11

0.378

EFNB2_HUMAN

Ephrin-B2

0.378

AMOL2_HUMAN

Angiomotin-like protein 2

0.378

FA20C_HUMAN

Extracellular serine/threonine protein kinase FAM20C

0.383

FBLN1_HUMAN

Fibulin-1

0.383

T22D2_HUMAN

TSC22 domain family protein 2

0.383

SATB1_HUMAN

DNA-binding protein SATB1

0.383

MTP_HUMAN

Microsomal triglyceride transfer protein large subunit

0.383

LEG9B_HUMAN

Galectin-9B

0.387

STOX2_HUMAN

Storkhead-box protein 2

0.387

LCOR_HUMAN

Ligand-dependent corepressor

0.392

MB211_HUMAN

Putative nucleotidyltransferase MAB21L1

0.394

BTBD7_HUMAN

BTB/POZ domain-containing protein 7

0.394

DACH1_HUMAN

Dachshund homolog 1

0.394

DACH2_HUMAN

Dachshund homolog 2

0.394

CSTN1_HUMAN

Calsyntenin-1

0.394

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.394

SALL4_HUMAN

Sal-like protein 4

0.399

CASC3_HUMAN

Protein CASC3

0.399

DLL1_HUMAN

Delta-like protein 1

0.399

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.399

ACM5_HUMAN

Muscarinic acetylcholine receptor M5

0.399

S12A8_HUMAN

Solute carrier family 12 member 8

0.399

SHF_HUMAN

SH2 domain-containing adapter protein F

0.399

NID1_HUMAN

Nidogen-1

0.399

DIRA2_HUMAN

GTP-binding protein Di-Ras2

0.399

PAR3L_HUMAN

Partitioning defective 3 homolog B

0.399

SYDE2_HUMAN

Rho GTPase-activating protein SYDE2

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

KIRR1_HUMAN

Kin of IRRE-like protein 1

0.340

LEG8_HUMAN

Galectin-8

0.347

RM51_HUMAN

39S ribosomal protein L51, mitochondrial

0.351

PROX1_HUMAN

Prospero homeobox protein 1

0.351

SALL1_HUMAN

Sal-like protein 1

0.353

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.353

NRCAM_HUMAN

Neuronal cell adhesion molecule

0.365

MESD_HUMAN

LRP chaperone MESD

0.365

NAB1_HUMAN

NGFI-A-binding protein 1

0.373

ABRA_HUMAN

Actin-binding Rho-activating protein

0.376

FA20C_HUMAN

Extracellular serine/threonine protein kinase FAM20C

0.376

STAU1_HUMAN

Double-stranded RNA-binding protein Staufen homolog 1

0.376

SPDEF_HUMAN

SAM pointed domain-containing Ets transcription factor

0.376

M3K5_HUMAN

Mitogen-activated protein kinase kinase kinase 5

0.376

VSX2_HUMAN

Visual system homeobox 2

0.377

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.380

HINFP_HUMAN

Histone H4 transcription factor

0.380

ERBB2_HUMAN

Receptor tyrosine-protein kinase erbB-2

0.380

BARH2_HUMAN

BarH-like 2 homeobox protein

0.382

SARM1_HUMAN

Sterile alpha and TIR motif-containing protein 1

0.382

MPRIP_HUMAN

Myosin phosphatase Rho-interacting protein

0.382

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.383

CUBN_HUMAN

Cubilin

0.384

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.385

NFASC_HUMAN

Neurofascin

0.385

FBX25_HUMAN

F-box only protein 25

0.385

SAV1_HUMAN

Protein salvador homolog 1

0.385

DCC_HUMAN

Netrin receptor DCC

0.385

ALK_HUMAN

ALK tyrosine kinase receptor

0.385

DOXA2_HUMAN

Dual oxidase maturation factor 2

0.386

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.386

FERM2_HUMAN

Fermitin family homolog 2

0.386

SNX27_HUMAN

Sorting nexin-27

0.386

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.386

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.387

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.387

HLF_HUMAN

Hepatic leukemia factor

0.387

NEO1_HUMAN

Neogenin

0.388

MYOD1_HUMAN

Myoblast determination protein 1

0.388

UNC79_HUMAN

Protein unc-79 homolog

0.388

RIPL1_HUMAN

RILP-like protein 1

0.388

CSTN1_HUMAN

Calsyntenin-1

0.388

STON1_HUMAN

Stonin-1

0.388

TULP4_HUMAN

Tubby-related protein 4

0.389

CELR3_HUMAN

Cadherin EGF LAG seven-pass G-type receptor 3

0.389

E41L5_HUMAN

Band 4.1-like protein 5

0.389

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.390

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.391

UNC5C_HUMAN

Netrin receptor UNC5C

0.391

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.392

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.392

AT1B4_HUMAN

Protein ATP1B4

0.392

FEZ2_HUMAN

Fasciculation and elongation protein zeta-2

0.392

BC11A_HUMAN

B-cell lymphoma/leukemia 11A

0.392

SKT_HUMAN

Sickle tail protein homolog

0.393

TEF_HUMAN

Thyrotroph embryonic factor

0.394

NAB2_HUMAN

NGFI-A-binding protein 2

0.394

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.395

BAF_HUMAN

Barrier-to-autointegration factor

0.395

RABE1_HUMAN

Rab GTPase-binding effector protein 1

0.396

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.396

LEG9B_HUMAN

Galectin-9B

0.396

SPRC_HUMAN

SPARC

0.396

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.397

MYT1_HUMAN

Myelin transcription factor 1

0.397

DAB1_HUMAN

Disabled homolog 1

0.397

5HT1A_HUMAN

5-hydroxytryptamine receptor 1A

0.397

CSPG4_HUMAN

Chondroitin sulfate proteoglycan 4

0.397

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.397

PRDM1_HUMAN

PR domain zinc finger protein 1

0.398

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.398

SYDE2_HUMAN

Rho GTPase-activating protein SYDE2

0.398

FERM1_HUMAN

Fermitin family homolog 1

0.398

VLDLR_HUMAN

Very low-density lipoprotein receptor

0.398

NCHL1_HUMAN

Neural cell adhesion molecule L1-like protein

0.399

P66B_HUMAN

Transcriptional repressor p66-beta

0.399

RM48_HUMAN

39S ribosomal protein L48, mitochondrial

0.399

RAB30_HUMAN

Ras-related protein Rab-30

0.400

E41LB_HUMAN

Band 4.1-like protein 4B

0.400

CHSS2_HUMAN

Chondroitin sulfate synthase 2

0.400

ACHA7_HUMAN

Neuronal acetylcholine receptor subunit alpha-7

0.400

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 173 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy