LMTD2_HUMAN 2019

Gene Name LMTD2

Description Lamin tail domain-containing protein 2

Length 634

9606

Sequence

>sp|Q8IXW0|LMTD2_HUMAN Lamin tail domain-containing protein 2
MRWLRPAGRRREQESVSGHLGPPAGAPAAPETPTCLPDTTPHPAPVVCSADPQLALESLDPRTLRLLWRQRELEIQALRWAIQNGEDARLCHILEEVAGLPPKRSSHSQEKLLQNQVQKLIQELKEQKERAQWEKEHLEERLLQTTRTLQEMEAELQNLQKSCLLQLARSSWVGRMLRSQTGSVEVVTAETLMDPSDLSENIQAPTGEGFRLEDVDWNSVARRYPNLFTNMEPSSKQKQPRPWPQLDTGSPESSGKHSERHHKTVEWGSLPCLNTSSSGGADSDSSSCRPGLPSFVQVIGHPPRDHRASSEQALVQAGSYSRDSEDLQKTHSPRHGEPVLSPQPCTDPDHWSPELLQSPTGLKIVAVSCREKFVRIFNPSQESTADLSGMVLKQLVRGFPERLYRFPPGTLLAPRHHVTVWGEATRSAKKPLRASSSREPVPLLSIRGCATLLLSPKGEVLSEHRIPRRETPAPRVFADGTDLSIDRFPLPEAGPGADTRKPPRPPRPLRKGRVREPRVSRRRPGTRGLLPPVSSGKLFHAREGPARPENPEIPAPQHLPAIPGDPTLPSPPAEAGLGLEDCRLQKEHRVRVCRKSVDRSCPLVALSVQNTAESRFGFRFLSCLPVTADTCRGA

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.000

O11G2_HUMAN

Olfactory receptor 11G2

0.000

FAIM3_HUMAN

Fas apoptotic inhibitory molecule 3

0.000

NIBL2_HUMAN

Niban-like protein 2

0.000

CNPY1_HUMAN

Protein canopy homolog 1

0.000

O10D4_HUMAN

Putative olfactory receptor 10D4

0.000

O11H6_HUMAN

Olfactory receptor 11H6

0.000

O6C74_HUMAN

Olfactory receptor 6C74

0.316

TBC21_HUMAN

TBC1 domain family member 21

0.316

TM156_HUMAN

Transmembrane protein 156

0.316

TNR4_HUMAN

Tumor necrosis factor receptor superfamily member 4

0.316

SMIM3_HUMAN

Small integral membrane protein 3

0.316

PRS53_HUMAN

Serine protease 53

0.316

CC159_HUMAN

Coiled-coil domain-containing protein 159

0.316

LIF_HUMAN

Leukemia inhibitory factor

0.316

TM207_HUMAN

Transmembrane protein 207

0.316

ABEC1_HUMAN

C->U-editing enzyme APOBEC-1

0.316

ACTT2_HUMAN

Actin-related protein T2

0.316

AKAP4_HUMAN

A-kinase anchor protein 4

0.316

SHLD1_HUMAN

Shieldin complex subunit 1

0.316

TACT_HUMAN

T-cell surface protein tactile

0.316

NKG7_HUMAN

Protein NKG7

0.316

NREP_HUMAN

Neuronal regeneration-related protein

0.316

XCL1_HUMAN

Lymphotactin

0.316

OR6C1_HUMAN

Olfactory receptor 6C1

0.316

CQ064_HUMAN

Uncharacterized protein C17orf64

0.316

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.316

HPIP_HUMAN

Host cell factor C1 regulator 1

0.316

SMRP1_HUMAN

Spermatid-specific manchette-related protein 1

0.316

ZN398_HUMAN

Zinc finger protein 398

0.316

HAVR2_HUMAN

Hepatitis A virus cellular receptor 2

0.316

TM139_HUMAN

Transmembrane protein 139

0.316

DMP1_HUMAN

Dentin matrix acidic phosphoprotein 1

0.316

PRS54_HUMAN

Inactive serine protease 54

0.316

LSME1_HUMAN

Leucine-rich single-pass membrane protein 1

0.316

CRLF2_HUMAN

Cytokine receptor-like factor 2

0.316

TRML1_HUMAN

Trem-like transcript 1 protein

0.333

O10D3_HUMAN

Putative olfactory receptor 10D3

0.333

TNFL9_HUMAN

Tumor necrosis factor ligand superfamily member 9

0.333

TMM92_HUMAN

Transmembrane protein 92

0.333

CH058_HUMAN

Uncharacterized protein C8orf58

0.333

X3CL1_HUMAN

Fractalkine

0.333

KRCC1_HUMAN

Lysine-rich coiled-coil protein 1

0.333

CCDC7_HUMAN

Coiled-coil domain-containing protein 7

0.333

OR9G4_HUMAN

Olfactory receptor 9G4

0.333

OR5I1_HUMAN

Olfactory receptor 5I1

0.333

OR9G1_HUMAN

Olfactory receptor 9G1

0.333

SSMM1_HUMAN

Serine-rich single-pass membrane protein 1

0.333

JAML_HUMAN

Junctional adhesion molecule-like

0.333

O10Q1_HUMAN

Olfactory receptor 10Q1

0.333

AMTN_HUMAN

Amelotin

0.333

SPT19_HUMAN

Spermatogenesis-associated protein 19, mitochondrial

0.333

ZN316_HUMAN

Zinc finger protein 316

0.333

S10A5_HUMAN

Protein S100-A5

0.333

OR5T1_HUMAN

Olfactory receptor 5T1

0.333

TM190_HUMAN

Transmembrane protein 190

0.333

HIDE1_HUMAN

Protein HIDE1

0.333

OR2T4_HUMAN

Olfactory receptor 2T4

0.333

SIT1_HUMAN

Signaling threshold-regulating transmembrane adapter 1

0.333

RAB42_HUMAN

Ras-related protein Rab-42

0.333

OR5T2_HUMAN

Olfactory receptor 5T2

0.333

O10V1_HUMAN

Olfactory receptor 10V1

0.333

BAFL_HUMAN

Barrier-to-autointegration factor-like protein

0.333

OR6S1_HUMAN

Olfactory receptor 6S1

0.333

MENT_HUMAN

Protein MENT

0.333

CC198_HUMAN

Uncharacterized protein CCDC198

0.333

CC182_HUMAN

Coiled-coil domain-containing protein 182

0.333

LY66C_HUMAN

Lymphocyte antigen 6 complex locus protein G6c

0.333

TEX38_HUMAN

Testis-expressed protein 38

0.333

OSTB_HUMAN

Organic solute transporter subunit beta

0.333

O52A5_HUMAN

Olfactory receptor 52A5

0.333

O11H4_HUMAN

Olfactory receptor 11H4

0.333

IZUM3_HUMAN

Izumo sperm-egg fusion protein 3

0.333

CF201_HUMAN

Uncharacterized protein C6orf201

0.333

CM046_HUMAN

Uncharacterized protein C13orf46

0.333

UPK3L_HUMAN

Uroplakin-3b-like protein 1

0.333

ERIC5_HUMAN

Glutamate-rich protein 5

0.333

SPT25_HUMAN

Spermatogenesis-associated protein 25

0.333

IL27A_HUMAN

Interleukin-27 subunit alpha

0.333

MSTRO_HUMAN

Protein maestro

0.333

TEX29_HUMAN

Testis-expressed protein 29

0.333

CD20_HUMAN

B-lymphocyte antigen CD20

0.333

OR4N5_HUMAN

Olfactory receptor 4N5

0.333

OR9I1_HUMAN

Olfactory receptor 9I1

0.333

DMRTD_HUMAN

Doublesex- and mab-3-related transcription factor C2

0.333

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.316

TBC21_HUMAN

TBC1 domain family member 21

0.339

S10A5_HUMAN

Protein S100-A5

0.342

ZKSC5_HUMAN

Zinc finger protein with KRAB and SCAN domains 5

0.344

TM219_HUMAN

Insulin-like growth factor-binding protein 3 receptor

0.344

IL1A_HUMAN

Interleukin-1 alpha

0.344

CJ120_HUMAN

Uncharacterized protein C10orf120

0.347

KRBA1_HUMAN

Protein KRBA1

0.347

PTCA_HUMAN

Protein tyrosine phosphatase receptor type C-associated protein

0.347

G6B_HUMAN

Megakaryocyte and platelet inhibitory receptor G6b

0.347

CC116_HUMAN

Coiled-coil domain-containing protein 116

0.347

LY6H_HUMAN

Lymphocyte antigen 6H

0.350

ZCCHL_HUMAN

Zinc finger CCCH-type antiviral protein 1-like

0.350

TSP50_HUMAN

Probable threonine protease PRSS50

0.354

AKAP4_HUMAN

A-kinase anchor protein 4

0.362

ZNF18_HUMAN

Zinc finger protein 18

0.365

TRML1_HUMAN

Trem-like transcript 1 protein

0.365

ZN202_HUMAN

Zinc finger protein 202

0.365

LAX1_HUMAN

Lymphocyte transmembrane adapter 1

0.365

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.365

NKG7_HUMAN

Protein NKG7

0.365

DKKL1_HUMAN

Dickkopf-like protein 1

0.368

TMCO2_HUMAN

Transmembrane and coiled-coil domain-containing protein 2

0.368

PRS37_HUMAN

Probable inactive serine protease 37

0.368

IL2_HUMAN

Interleukin-2

0.368

ZN496_HUMAN

Zinc finger protein 496

0.368

IL5_HUMAN

Interleukin-5

0.368

LAT_HUMAN

Linker for activation of T-cells family member 1

0.368

O13C7_HUMAN

Olfactory receptor 13C7

0.368

CSF2_HUMAN

Granulocyte-macrophage colony-stimulating factor

0.368

PRR19_HUMAN

Proline-rich protein 19

0.371

CLD9_HUMAN

Claudin-9

0.371

CCRL2_HUMAN

C-C chemokine receptor-like 2

0.371

CDSN_HUMAN

Corneodesmosin

0.371

ZSC25_HUMAN

Zinc finger and SCAN domain-containing protein 25

0.371

ETV2_HUMAN

ETS translocation variant 2

0.371

OCEL1_HUMAN

Occludin/ELL domain-containing protein 1

0.375

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.378

FSCN3_HUMAN

Fascin-3

0.378

DMRTD_HUMAN

Doublesex- and mab-3-related transcription factor C2

0.381

SPNDC_HUMAN

Spindlin interactor and repressor of chromatin-binding protein

0.384

AKAP3_HUMAN

A-kinase anchor protein 3

0.384

APOA2_HUMAN

Apolipoprotein A-II

0.384

MSTRO_HUMAN

Protein maestro

0.384

IL27A_HUMAN

Interleukin-27 subunit alpha

0.384

CD20_HUMAN

B-lymphocyte antigen CD20

0.384

SIT1_HUMAN

Signaling threshold-regulating transmembrane adapter 1

0.384

CNPY1_HUMAN

Protein canopy homolog 1

0.384

GL6D1_HUMAN

Putative glycosyltransferase 6 domain-containing protein 1

0.384

GPC5D_HUMAN

G-protein coupled receptor family C group 5 member D

0.384

CCDC7_HUMAN

Coiled-coil domain-containing protein 7

0.387

RTBDN_HUMAN

Retbindin

0.387

ZKSC2_HUMAN

Zinc finger protein with KRAB and SCAN domains 2

0.387

F186B_HUMAN

Protein FAM186B

0.387

ZKSC1_HUMAN

Zinc finger protein with KRAB and SCAN domains 1

0.387

CQ080_HUMAN

Uncharacterized protein C17orf80

0.387

RAGE_HUMAN

Advanced glycosylation end product-specific receptor

0.387

S10A8_HUMAN

Protein S100-A8

0.387

DMKN_HUMAN

Dermokine

0.387

CC196_HUMAN

Putative coiled-coil domain-containing protein 196

0.387

F170A_HUMAN

Protein FAM170A

0.391

CD70_HUMAN

CD70 antigen

0.391

DBND2_HUMAN

Dysbindin domain-containing protein 2

0.391

F229B_HUMAN

Protein FAM229B

0.391

NGAL_HUMAN

Neutrophil gelatinase-associated lipocalin

0.391

ZN263_HUMAN

Zinc finger protein 263

0.391

AMTN_HUMAN

Amelotin

0.391

ZFP1_HUMAN

Zinc finger protein 1 homolog

0.391

ZN189_HUMAN

Zinc finger protein 189

0.391

TRML2_HUMAN

Trem-like transcript 2 protein

0.391

TREM1_HUMAN

Triggering receptor expressed on myeloid cells 1

0.391

TMC5A_HUMAN

Transmembrane and coiled-coil domain-containing protein 5A

0.391

ZN200_HUMAN

Zinc finger protein 200

0.391

OPALI_HUMAN

Opalin

0.391

HDBP1_HUMAN

Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

0.394

MCEM1_HUMAN

Mast cell-expressed membrane protein 1

0.394

MRGRF_HUMAN

Mas-related G-protein coupled receptor member F

0.394

CE046_HUMAN

Uncharacterized protein C5orf46

0.394

SIM23_HUMAN

Small integral membrane protein 23

0.397

ZNF23_HUMAN

Zinc finger protein 23

0.397

LYPD4_HUMAN

Ly6/PLAUR domain-containing protein 4

0.397

GUC2B_HUMAN

Guanylate cyclase activator 2B

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 9 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy