RBIS_HUMAN 2019

Gene Name RBIS

Description Ribosomal biogenesis factor

Length 100

9606

Sequence

>sp|Q8N0T1|RBIS_HUMAN Ribosomal biogenesis factor
MAKNKLRGPKSRNVFHIASQKNFKAKNKAKPVTTNLKKINIMNEEKVNRVNKAFVNVQKELAHFAKSISLEPLQKELIPQQRHESKPVNVDEATRLMALL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

S10AD_HUMAN

Protein S100-A13

0.277

DAPL1_HUMAN

Death-associated protein-like 1

0.378

IL34_HUMAN

Interleukin-34

0.378

S10A4_HUMAN

Protein S100-A4

0.378

RNAS1_HUMAN

Ribonuclease pancreatic

0.392

S10AE_HUMAN

Protein S100-A14

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

IL1B_HUMAN

Interleukin-1 beta

0.339

K1522_HUMAN

Uncharacterized protein KIAA1522

0.339

I20RA_HUMAN

Interleukin-20 receptor subunit alpha

0.354

OBF1_HUMAN

POU domain class 2-associating factor 1

0.356

CAD13_HUMAN

Cadherin-13

0.358

IL12A_HUMAN

Interleukin-12 subunit alpha

0.360

DAPL1_HUMAN

Death-associated protein-like 1

0.362

S10AD_HUMAN

Protein S100-A13

0.364

PATZ1_HUMAN

POZ-, AT hook-, and zinc finger-containing protein 1

0.367

F131A_HUMAN

Protein FAM131A

0.367

CMGA_HUMAN

Chromogranin-A

0.367

MAL_HUMAN

Myelin and lymphocyte protein

0.367

TM182_HUMAN

Transmembrane protein 182

0.367

GZF1_HUMAN

GDNF-inducible zinc finger protein 1

0.369

NRN1_HUMAN

Neuritin

0.369

POF1B_HUMAN

Protein POF1B

0.369

I13R2_HUMAN

Interleukin-13 receptor subunit alpha-2

0.369

ZN185_HUMAN

Zinc finger protein 185

0.371

TKN1_HUMAN

Protachykinin-1

0.371

TUFT1_HUMAN

Tuftelin

0.371

PTTG1_HUMAN

Securin

0.371

NEUT_HUMAN

Neurotensin/neuromedin N

0.371

SPAG5_HUMAN

Sperm-associated antigen 5

0.374

IL34_HUMAN

Interleukin-34

0.376

IL19_HUMAN

Interleukin-19

0.376

LYRIC_HUMAN

Protein LYRIC

0.380

F131B_HUMAN

Protein FAM131B

0.380

AZI2_HUMAN

5-azacytidine-induced protein 2

0.380

FPRP_HUMAN

Prostaglandin F2 receptor negative regulator

0.380

TEFF1_HUMAN

Tomoregulin-1

0.380

CXCR4_HUMAN

C-X-C chemokine receptor type 4

0.380

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.380

LUZP1_HUMAN

Leucine zipper protein 1

0.380

ITGBL_HUMAN

Integrin beta-like protein 1

0.380

PTHR_HUMAN

Parathyroid hormone-related protein

0.380

CAD17_HUMAN

Cadherin-17

0.380

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.380

ANGT_HUMAN

Angiotensinogen

0.380

ABEC2_HUMAN

C->U-editing enzyme APOBEC-2

0.380

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.380

IL2RB_HUMAN

Interleukin-2 receptor subunit beta

0.382

ZBT26_HUMAN

Zinc finger and BTB domain-containing protein 26

0.382

SYNCI_HUMAN

Syncoilin

0.382

F163A_HUMAN

Protein FAM163A

0.382

C99L2_HUMAN

CD99 antigen-like protein 2

0.382

CR025_HUMAN

Uncharacterized protein C18orf25

0.382

HECA2_HUMAN

HEPACAM family member 2

0.384

CSTOS_HUMAN

Protein CUSTOS

0.384

UBP18_HUMAN

Ubl carboxyl-terminal hydrolase 18

0.384

ANF_HUMAN

Natriuretic peptides A

0.384

BTC_HUMAN

Probetacellulin

0.384

VTM2A_HUMAN

V-set and transmembrane domain-containing protein 2A

0.384

AGRP_HUMAN

Agouti-related protein

0.387

CC117_HUMAN

Coiled-coil domain-containing protein 117

0.387

FA83G_HUMAN

Protein FAM83G

0.387

MYOM3_HUMAN

Myomesin-3

0.387

KT222_HUMAN

Keratin-like protein KRT222

0.387

EREG_HUMAN

Proepiregulin

0.389

MAVS_HUMAN

Mitochondrial antiviral-signaling protein

0.389

CPLX4_HUMAN

Complexin-4

0.389

FANCG_HUMAN

Fanconi anemia group G protein

0.389

RHNO1_HUMAN

RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

0.391

LEAP2_HUMAN

Liver-expressed antimicrobial peptide 2

0.391

SGO1_HUMAN

Shugoshin 1

0.392

PRL_HUMAN

Prolactin

0.392

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.392

LEG1_HUMAN

Galectin-1

0.392

NEXMI_HUMAN

Neurite extension and migration factor

0.392

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.392

PDGFC_HUMAN

Platelet-derived growth factor C

0.392

PENK_HUMAN

Proenkephalin-A

0.392

SYBU_HUMAN

Syntabulin

0.392

ZN644_HUMAN

Zinc finger protein 644

0.392

MERB1_HUMAN

bMERB domain-containing protein 1

0.392

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.392

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.392

OCLN_HUMAN

Occludin

0.392

GHR_HUMAN

Growth hormone receptor

0.392

ZN131_HUMAN

Zinc finger protein 131

0.392

PCD19_HUMAN

Protocadherin-19

0.392

NPY_HUMAN

Pro-neuropeptide Y

0.392

AGRF5_HUMAN

Adhesion G protein-coupled receptor F5

0.392

MYZAP_HUMAN

Myocardial zonula adherens protein

0.392

CO8A_HUMAN

Complement component C8 alpha chain

0.392

PEDF_HUMAN

Pigment epithelium-derived factor

0.392

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.392

F168B_HUMAN

Myelin-associated neurite-outgrowth inhibitor

0.394

HBEGF_HUMAN

Proheparin-binding EGF-like growth factor

0.394

MRAP2_HUMAN

Melanocortin-2 receptor accessory protein 2

0.394

TNR1A_HUMAN

Tumor necrosis factor receptor superfamily member 1A

0.394

TNMD_HUMAN

Tenomodulin

0.394

MFR1L_HUMAN

Mitochondrial fission regulator 1-like

0.394

UIF_HUMAN

UAP56-interacting factor

0.394

MIME_HUMAN

Mimecan

0.394

XIRP2_HUMAN

Xin actin-binding repeat-containing protein 2

0.394

TSG6_HUMAN

Tumor necrosis factor-inducible gene 6 protein

0.394

TR150_HUMAN

Thyroid hormone receptor-associated protein 3

0.394

CCD30_HUMAN

Coiled-coil domain-containing protein 30

0.394

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.394

SCF_HUMAN

Kit ligand

0.394

F168A_HUMAN

Protein FAM168A

0.394

F180A_HUMAN

Protein FAM180A

0.394

R7BP_HUMAN

Regulator of G-protein signaling 7-binding protein

0.394

BSPRY_HUMAN

B box and SPRY domain-containing protein

0.394

K1107_HUMAN

AP2-interacting clathrin-endocytosis protein

0.394

BRNP1_HUMAN

BMP/retinoic acid-inducible neural-specific protein 1

0.397

CE024_HUMAN

UPF0461 protein C5orf24

0.397

LRC38_HUMAN

Leucine-rich repeat-containing protein 38

0.397

CAHM1_HUMAN

Calcium homeostasis modulator protein 1

0.397

RELL1_HUMAN

RELT-like protein 1

0.397

IL20_HUMAN

Interleukin-20

0.397

CLUL1_HUMAN

Clusterin-like protein 1

0.397

TASO2_HUMAN

Protein TASOR 2

0.397

CMYA5_HUMAN

Cardiomyopathy-associated protein 5

0.397

FGF19_HUMAN

Fibroblast growth factor 19

0.397

RN214_HUMAN

RING finger protein 214

0.397

MCR_HUMAN

Mineralocorticoid receptor

0.397

SLAF1_HUMAN

Signaling lymphocytic activation molecule

0.398

PLVAP_HUMAN

Plasmalemma vesicle-associated protein

0.399

HBA_HUMAN

Hemoglobin subunit alpha

0.399

R51A1_HUMAN

RAD51-associated protein 1

0.399

MCH_HUMAN

Pro-MCH

0.399

TMM25_HUMAN

Transmembrane protein 25

0.399

B2MG_HUMAN

Beta-2-microglobulin

0.399

MLIP_HUMAN

Muscular LMNA-interacting protein

0.399

TRDN_HUMAN

Triadin

0.399

CART_HUMAN

Cocaine- and amphetamine-regulated transcript protein

0.399

ZBT39_HUMAN

Zinc finger and BTB domain-containing protein 39

0.399

I11RA_HUMAN

Interleukin-11 receptor subunit alpha

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 12 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy