ENAH_HUMAN 2019

Gene Name ENAH

Description Protein enabled homolog

Length 591

9606

Sequence

>sp|Q8N8S7|ENAH_HUMAN Protein enabled homolog
MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPLSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

EVL_HUMAN

Ena/VASP-like protein

0.346

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

EVL_HUMAN

Ena/VASP-like protein

0.247

TEF_HUMAN

Thyrotroph embryonic factor

0.357

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.362

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.368

NUMB_HUMAN

Protein numb homolog

0.369

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.369

STK10_HUMAN

Serine/threonine-protein kinase 10

0.370

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.372

ITB1_HUMAN

Integrin beta-1

0.372

FLOWR_HUMAN

Calcium channel flower homolog

0.373

PDC10_HUMAN

Programmed cell death protein 10

0.373

HLF_HUMAN

Hepatic leukemia factor

0.375

RHG42_HUMAN

Rho GTPase-activating protein 42

0.375

CTNA1_HUMAN

Catenin alpha-1

0.375

TM39B_HUMAN

Transmembrane protein 39B

0.375

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.378

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.379

HINFP_HUMAN

Histone H4 transcription factor

0.380

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.380

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.380

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.380

AT1B4_HUMAN

Protein ATP1B4

0.380

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.381

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.382

MACOI_HUMAN

Macoilin

0.383

SLK_HUMAN

STE20-like serine/threonine-protein kinase

0.383

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.383

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.385

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.385

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.386

MTA1_HUMAN

Metastasis-associated protein MTA1

0.386

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.386

WLS_HUMAN

Protein wntless homolog

0.386

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.386

TRIO_HUMAN

Triple functional domain protein

0.386

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.386

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.387

MED8_HUMAN

Mediator of RNA polymerase II transcription subunit 8

0.387

MIGA1_HUMAN

Mitoguardin 1

0.387

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.388

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.389

AP2A_HUMAN

Transcription factor AP-2-alpha

0.390

RIMS4_HUMAN

Regulating synaptic membrane exocytosis protein 4

0.390

KPCD3_HUMAN

Serine/threonine-protein kinase D3

0.390

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.390

BMP2_HUMAN

Bone morphogenetic protein 2

0.390

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.391

PICK1_HUMAN

PRKCA-binding protein

0.391

MIGA2_HUMAN

Mitoguardin 2

0.391

RT22_HUMAN

28S ribosomal protein S22, mitochondrial

0.392

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.392

RIMB2_HUMAN

RIMS-binding protein 2

0.392

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.392

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.392

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.392

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.392

RSBN1_HUMAN

Lysine-specific demethylase 9

0.392

C43BP_HUMAN

Collagen type IV alpha-3-binding protein

0.393

KIRR1_HUMAN

Kin of IRRE-like protein 1

0.393

RUND1_HUMAN

RUN domain-containing protein 1

0.393

TSN5_HUMAN

Tetraspanin-5

0.393

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.393

MTCH2_HUMAN

Mitochondrial carrier homolog 2

0.393

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.393

ANLN_HUMAN

Anillin

0.393

TM39A_HUMAN

Transmembrane protein 39A

0.393

NDUAA_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

0.394

AFAD_HUMAN

Afadin

0.394

BAF_HUMAN

Barrier-to-autointegration factor

0.394

FA8A1_HUMAN

Protein FAM8A1

0.394

PACS1_HUMAN

Phosphofurin acidic cluster sorting protein 1

0.395

PO4F3_HUMAN

POU domain, class 4, transcription factor 3

0.395

CNTP1_HUMAN

Contactin-associated protein 1

0.395

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.395

RFIP3_HUMAN

Rab11 family-interacting protein 3

0.396

P66A_HUMAN

Transcriptional repressor p66-alpha

0.396

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.396

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.396

ARFP1_HUMAN

Arfaptin-1

0.396

PXDC2_HUMAN

Plexin domain-containing protein 2

0.397

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.397

TNIK_HUMAN

TRAF2 and NCK-interacting protein kinase

0.397

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.397

FERM1_HUMAN

Fermitin family homolog 1

0.397

SNX27_HUMAN

Sorting nexin-27

0.397

PP4P1_HUMAN

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.398

P66B_HUMAN

Transcriptional repressor p66-beta

0.398

MADD_HUMAN

MAP kinase-activating death domain protein

0.398

GIT2_HUMAN

ARF GTPase-activating protein GIT2

0.399

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.399

RIPL1_HUMAN

RILP-like protein 1

0.399

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.399

CSTN1_HUMAN

Calsyntenin-1

0.399

STIM2_HUMAN

Stromal interaction molecule 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 44 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy