FBX15_HUMAN 2019

Gene Name FBX15

Description F-box only protein 15

Length 510

9606

Sequence

>sp|Q8NCQ5|FBX15_HUMAN F-box only protein 15
MATGRGRILQQHWLGLQTLRGPSRGGGAARGRARAFGCRKGPGVKLSAGSAALRCHAGGGQHWESSFSCCSGFLDGMPSEILLKIFSYLDAVSLLCTGCVSRRFYHLANDNFIWIGIYSTAFSPARSNWKFNSVEKIAMSMSFLSVQDKEAGYWKKEYITKQIASVKAALADILKPVNPYTGLPVKTKEALRIFGLGWAIILKEKGGKEYIMEHVDLSINDTSVTVIWYGKKWPCLASLSTLDLCGMTPVFTDWYKTPTKHRLRWHSLIAKYNLSHLTISTMIGCDRLIRIFCLHPGLLVGVWKKEEELAFVMANLHFHHLVERSTLGSATIPYELPPHSPFLDDSPEYGLHGYQLHVDLHSGGVFYLCGTFRNLFTKRGNIENGHVKLIVIHLKNNREHLPLIGKVGLSWKTDIFDGCIKSCSMMDVTLLDEHGKPFWCFSSPVCLRSPATPSDSSSFLGQTYNVDYVDAEGRVHVELVWIRETEEYLIVNLVLYLSIAKINHWFGTEY

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

FBX4_HUMAN

F-box only protein 4

0.336

F167A_HUMAN

Protein FAM167A

0.339

USPL1_HUMAN

SUMO-specific isopeptidase USPL1

0.352

KNDC1_HUMAN

Kinase non-catalytic C-lobe domain-containing protein 1

0.352

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.355

AP1AR_HUMAN

AP-1 complex-associated regulatory protein

0.355

CCNF_HUMAN

Cyclin-F

0.361

SPICE_HUMAN

Spindle and centriole-associated protein 1

0.363

MTBP_HUMAN

Mdm2-binding protein

0.363

LRC42_HUMAN

Leucine-rich repeat-containing protein 42

0.363

BOREA_HUMAN

Borealin

0.363

PARI_HUMAN

PCNA-interacting partner

0.363

SNP47_HUMAN

Synaptosomal-associated protein 47

0.364

DERM_HUMAN

Dermatopontin

0.369

MIEAP_HUMAN

Mitochondria-eating protein

0.371

HECD4_HUMAN

Probable E3 ubiquitin-protein ligase HECTD4

0.371

FBXL5_HUMAN

F-box/LRR-repeat protein 5

0.371

IRF1_HUMAN

Interferon regulatory factor 1

0.371

CEP85_HUMAN

Centrosomal protein of 85 kDa

0.373

RD3_HUMAN

Protein RD3

0.375

NUSAP_HUMAN

Nucleolar and spindle-associated protein 1

0.376

ZFAT_HUMAN

Zinc finger protein ZFAT

0.378

F199X_HUMAN

Protein FAM199X

0.378

SLF2_HUMAN

SMC5-SMC6 complex localization factor protein 2

0.380

GSDME_HUMAN

Gasdermin-E

0.380

TALD3_HUMAN

Protein TALPID3

0.381

HNMT_HUMAN

Histamine N-methyltransferase

0.381

STXB4_HUMAN

Syntaxin-binding protein 4

0.383

FNDC1_HUMAN

Fibronectin type III domain-containing protein 1

0.383

TICRR_HUMAN

Treslin

0.384

TXD16_HUMAN

Thioredoxin domain-containing protein 16

0.384

ZFY27_HUMAN

Protrudin

0.386

NCOA4_HUMAN

Nuclear receptor coactivator 4

0.386

WDCP_HUMAN

WD repeat and coiled-coil-containing protein

0.386

MOONR_HUMAN

Protein moonraker

0.388

CF062_HUMAN

Uncharacterized protein C6orf62

0.388

PCD20_HUMAN

Protocadherin-20

0.388

ESR2_HUMAN

Estrogen receptor beta

0.388

MK06_HUMAN

Mitogen-activated protein kinase 6

0.390

MYO19_HUMAN

Unconventional myosin-XIX

0.390

HRH2_HUMAN

Histamine H2 receptor

0.390

SFRP3_HUMAN

Secreted frizzled-related protein 3

0.390

NXPE3_HUMAN

NXPE family member 3

0.390

PRDM4_HUMAN

PR domain zinc finger protein 4

0.390

CP20A_HUMAN

Cytochrome P450 20A1

0.391

SLAI2_HUMAN

SLAIN motif-containing protein 2

0.391

GP173_HUMAN

Probable G-protein coupled receptor 173

0.391

TNF10_HUMAN

Tumor necrosis factor ligand superfamily member 10

0.391

ZN451_HUMAN

E3 SUMO-protein ligase ZNF451

0.391

MTFR1_HUMAN

Mitochondrial fission regulator 1

0.391

IKBP1_HUMAN

Interleukin-1 receptor-associated kinase 1-binding protein 1

0.392

IRF2_HUMAN

Interferon regulatory factor 2

0.392

GARE1_HUMAN

GRB2-associated and regulator of MAPK protein 1

0.392

ENO4_HUMAN

Enolase 4

0.392

TARSH_HUMAN

Target of Nesh-SH3

0.393

PRDM2_HUMAN

PR domain zinc finger protein 2

0.393

DSE_HUMAN

Dermatan-sulfate epimerase

0.393

HUNK_HUMAN

Hormonally up-regulated neu tumor-associated kinase

0.394

DEND3_HUMAN

DENN domain-containing protein 3

0.394

CE034_HUMAN

Uncharacterized protein C5orf34

0.394

GP161_HUMAN

G-protein coupled receptor 161

0.394

CEP63_HUMAN

Centrosomal protein of 63 kDa

0.396

NKAP1_HUMAN

Uncharacterized protein NKAPD1

0.396

AGRV1_HUMAN

Adhesion G-protein coupled receptor V1

0.396

AMPO_HUMAN

Aminopeptidase O

0.397

USH2A_HUMAN

Usherin

0.398

CSPG2_HUMAN

Versican core protein

0.399

AFAP1_HUMAN

Actin filament-associated protein 1

0.399

LBN_HUMAN

Limbin

0.399

IL1AP_HUMAN

Interleukin-1 receptor accessory protein

0.399

DBLOH_HUMAN

Diablo homolog, mitochondrial

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 29 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy