CADM4_HUMAN 2019

Gene Name CADM4

Description Cell adhesion molecule 4

Length 388

9606

Sequence

>sp|Q8NFZ8|CADM4_HUMAN Cell adhesion molecule 4
MGRARRFQWPLLLLWAAAAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGSDGHKRKEEFFI

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TELT_HUMAN

Telethonin

0.243

APOE_HUMAN

Apolipoprotein E

0.243

ADML_HUMAN

ADM

0.333

VTCN1_HUMAN

V-set domain-containing T-cell activation inhibitor 1

0.333

TMM25_HUMAN

Transmembrane protein 25

0.333

CC136_HUMAN

Coiled-coil domain-containing protein 136

0.333

MN1_HUMAN

Transcriptional activator MN1

0.333

INKA1_HUMAN

PAK4-inhibitor INKA1

0.333

MALD2_HUMAN

MARVEL domain-containing protein 2

0.333

F1712_HUMAN

Protein FAM171A2

0.333

CC106_HUMAN

Coiled-coil domain-containing protein 106

0.333

CLD15_HUMAN

Claudin-15

0.333

LURA1_HUMAN

Leucine rich adaptor protein 1

0.333

DHX32_HUMAN

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

0.333

PPR1B_HUMAN

Protein phosphatase 1 regulatory subunit 1B

0.333

HEMO_HUMAN

Hemopexin

0.333

ADA2C_HUMAN

Alpha-2C adrenergic receptor

0.333

FOXR1_HUMAN

Forkhead box protein R1

0.333

FOXR2_HUMAN

Forkhead box protein R2

0.333

EPO_HUMAN

Erythropoietin

0.343

ADM2_HUMAN

Protein ADM2

0.343

HCAR1_HUMAN

Hydroxycarboxylic acid receptor 1

0.343

GPR4_HUMAN

G-protein coupled receptor 4

0.343

EX3L2_HUMAN

Exocyst complex component 3-like protein 2

0.343

STMD1_HUMAN

Stathmin domain-containing protein 1

0.343

CADM2_HUMAN

Cell adhesion molecule 2

0.387

IL2RG_HUMAN

Cytokine receptor common subunit gamma

0.397

SIG15_HUMAN

Sialic acid-binding Ig-like lectin 15

0.397

K1671_HUMAN

Uncharacterized protein KIAA1671

0.397

CNRG_HUMAN

Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.397

CCD30_HUMAN

Coiled-coil domain-containing protein 30

0.397

PERF_HUMAN

Perforin-1

0.397

HIC2_HUMAN

Hypermethylated in cancer 2 protein

0.397

T150B_HUMAN

Modulator of macroautophagy TMEM150B

0.397

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.397

PDYN_HUMAN

Proenkephalin-B

0.397

PAR2_HUMAN

Proteinase-activated receptor 2

0.397

CYTL1_HUMAN

Cytokine-like protein 1

0.397

CLUS_HUMAN

Clusterin

0.397

GPR17_HUMAN

Uracil nucleotide/cysteinyl leukotriene receptor

0.397

FA83C_HUMAN

Protein FAM83C

0.397

ZN513_HUMAN

Zinc finger protein 513

0.397

CAVN4_HUMAN

Caveolae-associated protein 4

0.397

CAD26_HUMAN

Cadherin-like protein 26

0.397

SCAR3_HUMAN

Scavenger receptor class A member 3

0.397

MAG_HUMAN

Myelin-associated glycoprotein

0.397

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.397

BSPRY_HUMAN

B box and SPRY domain-containing protein

0.397

CART_HUMAN

Cocaine- and amphetamine-regulated transcript protein

0.397

CSH1_HUMAN

Chorionic somatomammotropin hormone 1

0.397

P3IP1_HUMAN

Phosphoinositide-3-kinase-interacting protein 1

0.397

EPOR_HUMAN

Erythropoietin receptor

0.397

IBP2_HUMAN

Insulin-like growth factor-binding protein 2

0.397

F222A_HUMAN

Protein FAM222A

0.397

CK2N2_HUMAN

Calcium/calmodulin-dependent protein kinase II inhibitor 2

0.397

UIMC1_HUMAN

BRCA1-A complex subunit RAP80

0.397

MYP0_HUMAN

Myelin protein P0

0.397

CN028_HUMAN

Uncharacterized protein C14orf28

0.397

HXA13_HUMAN

Homeobox protein Hox-A13

0.397

INHA_HUMAN

Inhibin alpha chain

0.397

VTM2L_HUMAN

V-set and transmembrane domain-containing protein 2-like protein

0.397

CRBA4_HUMAN

Beta-crystallin A4

0.397

OCSTP_HUMAN

Osteoclast stimulatory transmembrane protein

0.397

PCD19_HUMAN

Protocadherin-19

0.397

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.397

CALCB_HUMAN

Calcitonin gene-related peptide 2

0.397

ZN438_HUMAN

Zinc finger protein 438

0.397

HEG1_HUMAN

Protein HEG homolog 1

0.397

CPLX3_HUMAN

Complexin-3

0.397

RHNO1_HUMAN

RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

0.397

ARTN_HUMAN

Artemin

0.397

SOMA_HUMAN

Somatotropin

0.397

CSH2_HUMAN

Chorionic somatomammotropin hormone 2

0.397

K1C14_HUMAN

Keratin, type I cytoskeletal 14

0.397

ZN217_HUMAN

Zinc finger protein 217

0.397

CX038_HUMAN

Uncharacterized protein CXorf38

0.397

SOM2_HUMAN

Growth hormone variant

0.397

CEAM5_HUMAN

Carcinoembryonic antigen-related cell adhesion molecule 5

0.397

RN214_HUMAN

RING finger protein 214

0.397

SRPX2_HUMAN

Sushi repeat-containing protein SRPX2

0.397

TOR4A_HUMAN

Torsin-4A

0.397

SE6L1_HUMAN

Seizure 6-like protein

0.397

ESAM_HUMAN

Endothelial cell-selective adhesion molecule

0.397

SPRY4_HUMAN

SPRY domain-containing protein 4

0.397

CADM3_HUMAN

Cell adhesion molecule 3

0.397

PRR35_HUMAN

Proline-rich protein 35

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CLD15_HUMAN

Claudin-15

0.345

MAG_HUMAN

Myelin-associated glycoprotein

0.371

TELT_HUMAN

Telethonin

0.374

SCN1B_HUMAN

Sodium channel subunit beta-1

0.374

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.374

RHBD3_HUMAN

Rhomboid domain-containing protein 3

0.376

EPOR_HUMAN

Erythropoietin receptor

0.387

SPRY4_HUMAN

SPRY domain-containing protein 4

0.387

CC136_HUMAN

Coiled-coil domain-containing protein 136

0.389

CC106_HUMAN

Coiled-coil domain-containing protein 106

0.391

EPO_HUMAN

Erythropoietin

0.393

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 17 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy