WHAMM_HUMAN 2019

Gene Name WHAMM

Description WASP homolog-associated protein with actin, membranes and microtubules

Length 809

9606

Sequence

>sp|Q8TF30|WHAMM_HUMAN WASP homolog-associated protein with actin, membranes and microtubules
MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGARLGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAWGLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADCESPREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQYLLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITVNYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERSIKAALQRIKRVSADSEEDSDEQDPGQWDG

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

MPP9_HUMAN

M-phase phosphoprotein 9

0.361

AKAP6_HUMAN

A-kinase anchor protein 6

0.361

H13_HUMAN

Histone H1.3

0.378

H14_HUMAN

Histone H1.4

0.378

JMY_HUMAN

Junction-mediating and -regulatory protein

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NTF3_HUMAN

Neurotrophin-3

0.284

BDNF_HUMAN

Brain-derived neurotrophic factor

0.302

NGF_HUMAN

Beta-nerve growth factor

0.318

GPBL1_HUMAN

Vasculin-like protein 1

0.359

PRLR_HUMAN

Prolactin receptor

0.361

FANCC_HUMAN

Fanconi anemia group C protein

0.361

WDCP_HUMAN

WD repeat and coiled-coil-containing protein

0.365

CDON_HUMAN

Cell adhesion molecule-related/down-regulated by oncogenes

0.367

JMY_HUMAN

Junction-mediating and -regulatory protein

0.367

GPR63_HUMAN

Probable G-protein coupled receptor 63

0.370

SLAI2_HUMAN

SLAIN motif-containing protein 2

0.370

PRDM2_HUMAN

PR domain zinc finger protein 2

0.372

TARSH_HUMAN

Target of Nesh-SH3

0.372

PANX1_HUMAN

Pannexin-1

0.372

ARG33_HUMAN

Rho guanine nucleotide exchange factor 33

0.372

GAK1B_HUMAN

Golgi-associated kinase 1B

0.374

CCG1_HUMAN

Voltage-dependent calcium channel gamma-1 subunit

0.374

CC127_HUMAN

Coiled-coil domain-containing protein 127

0.374

EVC_HUMAN

Ellis-van Creveld syndrome protein

0.376

GDF9_HUMAN

Growth/differentiation factor 9

0.378

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.378

IMPG1_HUMAN

Interphotoreceptor matrix proteoglycan 1

0.378

PEPL_HUMAN

Periplakin

0.378

SOGA1_HUMAN

Protein SOGA1

0.378

CAVN2_HUMAN

Caveolae-associated protein 2

0.378

FOXM1_HUMAN

Forkhead box protein M1

0.380

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.380

AFAP1_HUMAN

Actin filament-associated protein 1

0.380

ZFAT_HUMAN

Zinc finger protein ZFAT

0.380

MYPN_HUMAN

Myopalladin

0.382

AF1L1_HUMAN

Actin filament-associated protein 1-like 1

0.382

SLAI1_HUMAN

SLAIN motif-containing protein 1

0.382

MPP9_HUMAN

M-phase phosphoprotein 9

0.382

AF1L2_HUMAN

Actin filament-associated protein 1-like 2

0.382

CASC4_HUMAN

Protein CASC4

0.383

MATR3_HUMAN

Matrin-3

0.383

I17RA_HUMAN

Interleukin-17 receptor A

0.383

AROS_HUMAN

Active regulator of SIRT1

0.383

RET4_HUMAN

Retinol-binding protein 4

0.383

K154L_HUMAN

UPF0606 protein KIAA1549L

0.385

HMGX3_HUMAN

HMG domain-containing protein 3

0.385

DKK2_HUMAN

Dickkopf-related protein 2

0.385

FNDC1_HUMAN

Fibronectin type III domain-containing protein 1

0.385

AKAP6_HUMAN

A-kinase anchor protein 6

0.385

IMPG2_HUMAN

Interphotoreceptor matrix proteoglycan 2

0.385

PARI_HUMAN

PCNA-interacting partner

0.387

ASB4_HUMAN

Ankyrin repeat and SOCS box protein 4

0.387

NR0B2_HUMAN

Nuclear receptor subfamily 0 group B member 2

0.387

CCD80_HUMAN

Coiled-coil domain-containing protein 80

0.387

PTN_HUMAN

Pleiotrophin

0.387

TM206_HUMAN

Transmembrane protein 206

0.387

GPR83_HUMAN

Probable G-protein coupled receptor 83

0.389

ZP3_HUMAN

Zona pellucida sperm-binding protein 3

0.389

BFSP1_HUMAN

Filensin

0.389

CCR7_HUMAN

C-C chemokine receptor type 7

0.389

SCG3_HUMAN

Secretogranin-3

0.389

LUR1L_HUMAN

Leucine rich adaptor protein 1-like

0.389

TMM51_HUMAN

Transmembrane protein 51

0.389

CDCP1_HUMAN

CUB domain-containing protein 1

0.389

HDX_HUMAN

Highly divergent homeobox

0.389

FMOD_HUMAN

Fibromodulin

0.389

ZN335_HUMAN

Zinc finger protein 335

0.389

CLD11_HUMAN

Claudin-11

0.389

MREG_HUMAN

Melanoregulin

0.389

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.389

SPIN1_HUMAN

Spindlin-1

0.389

CXD2_HUMAN

Gap junction delta-2 protein

0.389

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.389

PCD20_HUMAN

Protocadherin-20

0.390

OX2G_HUMAN

OX-2 membrane glycoprotein

0.391

SHSA2_HUMAN

Protein shisa-2 homolog

0.391

GPR39_HUMAN

G-protein coupled receptor 39

0.391

SDF1_HUMAN

Stromal cell-derived factor 1

0.391

DSG2_HUMAN

Desmoglein-2

0.391

MAL2_HUMAN

Protein MAL2

0.391

PRDM4_HUMAN

PR domain zinc finger protein 4

0.392

NODAL_HUMAN

Nodal homolog

0.392

FANCB_HUMAN

Fanconi anemia group B protein

0.392

FSD2_HUMAN

Fibronectin type III and SPRY domain-containing protein 2

0.393

GP173_HUMAN

Probable G-protein coupled receptor 173

0.394

ICE1_HUMAN

Little elongation complex subunit 1

0.394

CLN6_HUMAN

Ceroid-lipofuscinosis neuronal protein 6

0.394

LRP12_HUMAN

Low-density lipoprotein receptor-related protein 12

0.395

ANKH_HUMAN

Progressive ankylosis protein homolog

0.396

CCD32_HUMAN

Coiled-coil domain-containing protein 32

0.396

B2L13_HUMAN

Bcl-2-like protein 13

0.396

CSF3R_HUMAN

Granulocyte colony-stimulating factor receptor

0.396

STC2_HUMAN

Stanniocalcin-2

0.398

BEND4_HUMAN

BEN domain-containing protein 4

0.398

CXAR_HUMAN

Coxsackievirus and adenovirus receptor

0.398

PANX3_HUMAN

Pannexin-3

0.398

CJ088_HUMAN

Uncharacterized protein C10orf88

0.398

NPNT_HUMAN

Nephronectin

0.398

EURL_HUMAN

Protein EURL homolog

0.398

TNIP2_HUMAN

TNFAIP3-interacting protein 2

0.398

USPL1_HUMAN

SUMO-specific isopeptidase USPL1

0.399

NPY_HUMAN

Pro-neuropeptide Y

0.400

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.400

ASTN1_HUMAN

Astrotactin-1

0.400

PXDC1_HUMAN

PX domain-containing protein 1

0.400

NHSL1_HUMAN

NHS-like protein 1

0.400

OCLN_HUMAN

Occludin

0.400

STYK1_HUMAN

Tyrosine-protein kinase STYK1

0.400

MERB1_HUMAN

bMERB domain-containing protein 1

0.400

PCD19_HUMAN

Protocadherin-19

0.400

LARGN_HUMAN

Protein Largen

0.400

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.400

CFLAR_HUMAN

CASP8 and FADD-like apoptosis regulator

0.400

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.400

CRBB1_HUMAN

Beta-crystallin B1

0.400

PDGFC_HUMAN

Platelet-derived growth factor C

0.400

GHR_HUMAN

Growth hormone receptor

0.400

PENK_HUMAN

Proenkephalin-A

0.400

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.400

MYZAP_HUMAN

Myocardial zonula adherens protein

0.400

ZN131_HUMAN

Zinc finger protein 131

0.400

NEXMI_HUMAN

Neurite extension and migration factor

0.400

ZN644_HUMAN

Zinc finger protein 644

0.400

CALD1_HUMAN

Caldesmon

0.400

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.400

PRL_HUMAN

Prolactin

0.400

LEG1_HUMAN

Galectin-1

0.400

SYBU_HUMAN

Syntabulin

0.400

SGO1_HUMAN

Shugoshin 1

0.400

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 93 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy