LMBR1_HUMAN 2019

Gene Name LMBR1

Description Limb region 1 protein homolog

Length 490

9606

Sequence

>sp|Q8WVP7|LMBR1_HUMAN Limb region 1 protein homolog
MEGQDEVSAREQHFHSQVRESTICFLLFAILYVVSYFIITRYKRKSDEQEDEDAIVNRISLFLSTFTLAVSAGAVLLLPFSIISNEILLSFPQNYYIQWLNGSLIHGLWNLASLFSNLCLFVLMPFAFFFLESEGFAGLKKGIRARILETLVMLLLLALLILGIVWVASALIDNDAASMESLYDLWEFYLPYLYSCISLMGCLLLLLCTPVGLSRMFTVMGQLLVKPTILEDLDEQIYIITLEEEALQRRLNGLSSSVEYNIMELEQELENVKTLKTKLERRKKASAWERNLVYPAVMVLLLIETSISVLLVACNILCLLVDETAMPKGTRGPGIGNASLSTFGFVGAALEIILIFYLMVSSVVGFYSLRFFGNFTPKKDDTTMTKIIGNCVSILVLSSALPVMSRTLGITRFDLLGDFGRFNWLGNFYIVLSYNLLFAIVTTLCLVRKFTSAVREELFKALGLHKLHLPNTSRDSETAKPSVNGHQKAL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

LMBRL_HUMAN

Protein LMBR1L

0.272

INT14_HUMAN

Integrator complex subunit 14

0.299

INT13_HUMAN

Integrator complex subunit 13

0.330

WLS_HUMAN

Protein wntless homolog

0.333

FERM1_HUMAN

Fermitin family homolog 1

0.357

FERM2_HUMAN

Fermitin family homolog 2

0.357

SYT1_HUMAN

Synaptotagmin-1

0.357

RUNX2_HUMAN

Runt-related transcription factor 2

0.357

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.357

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.360

PARD3_HUMAN

Partitioning defective 3 homolog

0.360

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.360

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.360

HTF4_HUMAN

Transcription factor 12

0.360

AT1B4_HUMAN

Protein ATP1B4

0.360

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.360

JPH1_HUMAN

Junctophilin-1

0.360

WNT5A_HUMAN

Protein Wnt-5a

0.360

RUND1_HUMAN

RUN domain-containing protein 1

0.360

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.378

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.378

PXDN_HUMAN

Peroxidasin homolog

0.381

CTNA1_HUMAN

Catenin alpha-1

0.381

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.381

GFI1_HUMAN

Zinc finger protein Gfi-1

0.381

T2FA_HUMAN

General transcription factor IIF subunit 1

0.381

IRX4_HUMAN

Iroquois-class homeodomain protein IRX-4

0.381

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.381

SETB1_HUMAN

Histone-lysine N-methyltransferase SETDB1

0.381

TGFR1_HUMAN

TGF-beta receptor type-1

0.381

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.381

BMP2_HUMAN

Bone morphogenetic protein 2

0.381

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.381

TF3C1_HUMAN

General transcription factor 3C polypeptide 1

0.381

TSN5_HUMAN

Tetraspanin-5

0.385

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.385

NFIB_HUMAN

Nuclear factor 1 B-type

0.385

FOXO1_HUMAN

Forkhead box protein O1

0.385

LIPA1_HUMAN

Liprin-alpha-1

0.385

PTPRN_HUMAN

Receptor-type tyrosine-protein phosphatase-like N

0.385

NAV2_HUMAN

Neuron navigator 2

0.385

FEM1C_HUMAN

Protein fem-1 homolog C

0.385

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.385

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.385

STON1_HUMAN

Stonin-1

0.385

FOXO3_HUMAN

Forkhead box protein O3

0.385

AP2B_HUMAN

Transcription factor AP-2-beta

0.385

ITF2_HUMAN

Transcription factor 4

0.385

VANG1_HUMAN

Vang-like protein 1

0.385

FA8A1_HUMAN

Protein FAM8A1

0.385

HINFP_HUMAN

Histone H4 transcription factor

0.385

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.385

FABP7_HUMAN

Fatty acid-binding protein, brain

0.385

RIPL1_HUMAN

RILP-like protein 1

0.385

JPH3_HUMAN

Junctophilin-3

0.385

AP2A_HUMAN

Transcription factor AP-2-alpha

0.385

NFIA_HUMAN

Nuclear factor 1 A-type

0.385

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.385

TFE2_HUMAN

Transcription factor E2-alpha

0.385

RN146_HUMAN

E3 ubiquitin-protein ligase RNF146

0.385

MED17_HUMAN

Mediator of RNA polymerase II transcription subunit 17

0.391

UNC80_HUMAN

Protein unc-80 homolog

0.394

KSR1_HUMAN

Kinase suppressor of Ras 1

0.394

ARFP1_HUMAN

Arfaptin-1

0.397

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.397

AFAD_HUMAN

Afadin

0.397

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.397

MK10_HUMAN

Mitogen-activated protein kinase 10

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

LMBRL_HUMAN

Protein LMBR1L

0.280

NDUAA_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

0.349

AFAD_HUMAN

Afadin

0.361

FA8A1_HUMAN

Protein FAM8A1

0.372

TRIO_HUMAN

Triple functional domain protein

0.375

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.375

INT13_HUMAN

Integrator complex subunit 13

0.375

PCKGC_HUMAN

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

0.376

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.379

BMP2_HUMAN

Bone morphogenetic protein 2

0.380

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.381

AT1B4_HUMAN

Protein ATP1B4

0.381

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.381

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.381

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.381

RUND1_HUMAN

RUN domain-containing protein 1

0.382

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.384

ITB1_HUMAN

Integrin beta-1

0.384

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.385

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.386

FERM1_HUMAN

Fermitin family homolog 1

0.386

FERM2_HUMAN

Fermitin family homolog 2

0.386

WLS_HUMAN

Protein wntless homolog

0.386

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.386

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.386

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.386

MED17_HUMAN

Mediator of RNA polymerase II transcription subunit 17

0.387

BICD2_HUMAN

Protein bicaudal D homolog 2

0.387

CSTN1_HUMAN

Calsyntenin-1

0.388

RIPL1_HUMAN

RILP-like protein 1

0.388

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.390

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.391

HINFP_HUMAN

Histone H4 transcription factor

0.391

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.391

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.391

RSBN1_HUMAN

Lysine-specific demethylase 9

0.392

NUMB_HUMAN

Protein numb homolog

0.392

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.392

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.392

RIMB2_HUMAN

RIMS-binding protein 2

0.392

TBX20_HUMAN

T-box transcription factor TBX20

0.393

HTF4_HUMAN

Transcription factor 12

0.393

BICD1_HUMAN

Protein bicaudal D homolog 1

0.393

TSN5_HUMAN

Tetraspanin-5

0.393

NDST1_HUMAN

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

0.394

PACS1_HUMAN

Phosphofurin acidic cluster sorting protein 1

0.394

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.396

ARFP1_HUMAN

Arfaptin-1

0.396

WDR37_HUMAN

WD repeat-containing protein 37

0.396

VINC_HUMAN

Vinculin

0.398

TPST1_HUMAN

Protein-tyrosine sulfotransferase 1

0.398

MADD_HUMAN

MAP kinase-activating death domain protein

0.398

NDST2_HUMAN

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

0.398

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.399

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.399

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.399

UNC79_HUMAN

Protein unc-79 homolog

0.399

STON1_HUMAN

Stonin-1

0.399

ACK1_HUMAN

Activated CDC42 kinase 1

0.400

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.400

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 54 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy