PSPC1_HUMAN 2019

Gene Name PSPC1

Description Paraspeckle component 1

Length 523

9606

Sequence

>sp|Q8WXF1|PSPC1_HUMAN Paraspeckle component 1
MMLRGNLKQVRIEKNPARLRALESAVGESEPAAAAAMALALAGEPAPPAPAPPEDHPDEEMGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGFKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGNQGPPPMMGMNMNNRATIPGPPMGPGPAMGPEGAANMGTPMMPDNGAVHNDRFPQGPPSQMGSPMGSRTGSETPQAPMSGVGPVSGGPGGFGRGSQGGNFEGPNKRRRY

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NONO_HUMAN

Non-POU domain-containing octamer-binding protein

0.255

SFPQ_HUMAN

Splicing factor, proline- and glutamine-rich

0.258

HES1_HUMAN

Transcription factor HES-1

0.365

DAG1_HUMAN

Dystroglycan

0.386

PEBB_HUMAN

Core-binding factor subunit beta

0.386

MAFK_HUMAN

Transcription factor MafK

0.390

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.390

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.390

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.390

MCF2L_HUMAN

Guanine nucleotide exchange factor DBS

0.390

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.394

CC85A_HUMAN

Coiled-coil domain-containing protein 85A

0.394

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NONO_HUMAN

Non-POU domain-containing octamer-binding protein

0.244

SFPQ_HUMAN

Splicing factor, proline- and glutamine-rich

0.274

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.365

HLF_HUMAN

Hepatic leukemia factor

0.366

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.371

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.372

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.373

EPHA4_HUMAN

Ephrin type-A receptor 4

0.373

TEF_HUMAN

Thyrotroph embryonic factor

0.373

MACOI_HUMAN

Macoilin

0.373

PRIC2_HUMAN

Prickle-like protein 2

0.373

TSHR_HUMAN

Thyrotropin receptor

0.375

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.376

DAG1_HUMAN

Dystroglycan

0.377

TRIO_HUMAN

Triple functional domain protein

0.377

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.377

AP2B_HUMAN

Transcription factor AP-2-beta

0.380

KPCD3_HUMAN

Serine/threonine-protein kinase D3

0.381

BMP2_HUMAN

Bone morphogenetic protein 2

0.381

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.382

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.382

AT1B4_HUMAN

Protein ATP1B4

0.382

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.383

HES1_HUMAN

Transcription factor HES-1

0.383

ANLN_HUMAN

Anillin

0.384

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.385

ITB1_HUMAN

Integrin beta-1

0.386

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.386

CUBN_HUMAN

Cubilin

0.386

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.387

MPDZ_HUMAN

Multiple PDZ domain protein

0.387

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.388

SNX27_HUMAN

Sorting nexin-27

0.389

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.389

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.389

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.389

WLS_HUMAN

Protein wntless homolog

0.389

CTNA1_HUMAN

Catenin alpha-1

0.389

RHG42_HUMAN

Rho GTPase-activating protein 42

0.389

NEO1_HUMAN

Neogenin

0.390

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.390

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.390

STON1_HUMAN

Stonin-1

0.390

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.390

FOXO1_HUMAN

Forkhead box protein O1

0.391

LAMC1_HUMAN

Laminin subunit gamma-1

0.392

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.392

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.392

PRIC1_HUMAN

Prickle-like protein 1

0.392

LIPB1_HUMAN

Liprin-beta-1

0.392

STON2_HUMAN

Stonin-2

0.392

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.393

PLXA2_HUMAN

Plexin-A2

0.394

HINFP_HUMAN

Histone H4 transcription factor

0.394

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.394

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.395

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.395

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.395

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.395

FOXO3_HUMAN

Forkhead box protein O3

0.395

NUMB_HUMAN

Protein numb homolog

0.395

RC3H2_HUMAN

Roquin-2

0.395

LSHR_HUMAN

Lutropin-choriogonadotropic hormone receptor

0.395

RUND1_HUMAN

RUN domain-containing protein 1

0.395

BICD1_HUMAN

Protein bicaudal D homolog 1

0.395

HTF4_HUMAN

Transcription factor 12

0.395

TSN5_HUMAN

Tetraspanin-5

0.395

AFAD_HUMAN

Afadin

0.396

FSHR_HUMAN

Follicle-stimulating hormone receptor

0.396

RUNX2_HUMAN

Runt-related transcription factor 2

0.396

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.396

JKAMP_HUMAN

JNK1/MAPK8-associated membrane protein

0.396

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.397

TAOK1_HUMAN

Serine/threonine-protein kinase TAO1

0.398

DAB1_HUMAN

Disabled homolog 1

0.398

SAV1_HUMAN

Protein salvador homolog 1

0.398

MYT1_HUMAN

Myelin transcription factor 1

0.398

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.398

PDC10_HUMAN

Programmed cell death protein 10

0.399

ARFP1_HUMAN

Arfaptin-1

0.399

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.399

RT30_HUMAN

39S ribosomal protein S30, mitochondrial

0.399

NFIB_HUMAN

Nuclear factor 1 B-type

0.399

NAB1_HUMAN

NGFI-A-binding protein 1

0.399

FERM2_HUMAN

Fermitin family homolog 2

0.400

FERM1_HUMAN

Fermitin family homolog 1

0.400

AMD_HUMAN

Peptidyl-glycine alpha-amidating monooxygenase

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 43 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy