SIA8A_HUMAN 2019

Gene Name SIA8A

Description Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

Length 356

9606

Sequence

>sp|Q92185|SIA8A_HUMAN Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGSKSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHYYDNVLPFSGFHAMPEEFLQLWYLHKIGALRMQLDPCEDTSLQPTS

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SIA8E_HUMAN

Alpha-2,8-sialyltransferase 8E

0.000

SIA8C_HUMAN

Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase

0.196

SIA8B_HUMAN

Alpha-2,8-sialyltransferase 8B

0.333

GPR61_HUMAN

G-protein coupled receptor 61

0.400

DRAXI_HUMAN

Draxin

0.400

SIA8F_HUMAN

Alpha-2,8-sialyltransferase 8F

0.400

LR75A_HUMAN

Leucine-rich repeat-containing protein 75A

0.400

CC127_HUMAN

Coiled-coil domain-containing protein 127

0.400

PRDM2_HUMAN

PR domain zinc finger protein 2

0.400

MREG_HUMAN

Melanoregulin

0.400

HDX_HUMAN

Highly divergent homeobox

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SIA8C_HUMAN

Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase

0.310

PRDM2_HUMAN

PR domain zinc finger protein 2

0.359

GAK1B_HUMAN

Golgi-associated kinase 1B

0.361

LARGN_HUMAN

Protein Largen

0.362

RET4_HUMAN

Retinol-binding protein 4

0.370

FANCC_HUMAN

Fanconi anemia group C protein

0.372

PRLR_HUMAN

Prolactin receptor

0.372

SIA8E_HUMAN

Alpha-2,8-sialyltransferase 8E

0.373

ASB4_HUMAN

Ankyrin repeat and SOCS box protein 4

0.374

CXD2_HUMAN

Gap junction delta-2 protein

0.376

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.376

F1711_HUMAN

Protein FAM171A1

0.376

ITGBL_HUMAN

Integrin beta-like protein 1

0.376

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.376

RAB12_HUMAN

Ras-related protein Rab-12

0.376

CLD11_HUMAN

Claudin-11

0.376

FMOD_HUMAN

Fibromodulin

0.376

ZN335_HUMAN

Zinc finger protein 335

0.376

CCR7_HUMAN

C-C chemokine receptor type 7

0.376

GPR61_HUMAN

G-protein coupled receptor 61

0.378

ZN711_HUMAN

Zinc finger protein 711

0.378

TARSH_HUMAN

Target of Nesh-SH3

0.383

CC127_HUMAN

Coiled-coil domain-containing protein 127

0.385

STC2_HUMAN

Stanniocalcin-2

0.385

EURL_HUMAN

Protein EURL homolog

0.385

CXAR_HUMAN

Coxsackievirus and adenovirus receptor

0.385

BEND4_HUMAN

BEN domain-containing protein 4

0.385

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.387

ZN644_HUMAN

Zinc finger protein 644

0.387

NEXMI_HUMAN

Neurite extension and migration factor

0.387

NPY_HUMAN

Pro-neuropeptide Y

0.387

PDGFC_HUMAN

Platelet-derived growth factor C

0.387

GHR_HUMAN

Growth hormone receptor

0.387

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.387

MYZAP_HUMAN

Myocardial zonula adherens protein

0.387

PENK_HUMAN

Proenkephalin-A

0.387

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.387

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.387

MERB1_HUMAN

bMERB domain-containing protein 1

0.387

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.387

SYBU_HUMAN

Syntabulin

0.387

CRBB1_HUMAN

Beta-crystallin B1

0.387

STYK1_HUMAN

Tyrosine-protein kinase STYK1

0.387

BEND7_HUMAN

BEN domain-containing protein 7

0.387

ASTN1_HUMAN

Astrotactin-1

0.387

CFLAR_HUMAN

CASP8 and FADD-like apoptosis regulator

0.387

OCLN_HUMAN

Occludin

0.387

ZN131_HUMAN

Zinc finger protein 131

0.387

LEG1_HUMAN

Galectin-1

0.387

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.387

PRL_HUMAN

Prolactin

0.387

SGO1_HUMAN

Shugoshin 1

0.387

ZBT20_HUMAN

Zinc finger and BTB domain-containing protein 20

0.389

F168B_HUMAN

Myelin-associated neurite-outgrowth inhibitor

0.389

PEPL_HUMAN

Periplakin

0.389

SOGA1_HUMAN

Protein SOGA1

0.389

CAVN2_HUMAN

Caveolae-associated protein 2

0.389

ZN148_HUMAN

Zinc finger protein 148

0.389

GDF9_HUMAN

Growth/differentiation factor 9

0.389

TSN1_HUMAN

Tetraspanin-1

0.389

F222B_HUMAN

Protein FAM222B

0.389

GP176_HUMAN

G-protein coupled receptor 176

0.389

CCPG1_HUMAN

Cell cycle progression protein 1

0.389

ERRFI_HUMAN

ERBB receptor feedback inhibitor 1

0.389

TRADD_HUMAN

Tumor necrosis factor receptor type 1-associated DEATH domain protein

0.391

CAHM1_HUMAN

Calcium homeostasis modulator protein 1

0.391

HNMT_HUMAN

Histamine N-methyltransferase

0.394

GPBL1_HUMAN

Vasculin-like protein 1

0.394

MATR3_HUMAN

Matrin-3

0.394

AROS_HUMAN

Active regulator of SIRT1

0.394

NHLC3_HUMAN

NHL repeat-containing protein 3

0.394

K154L_HUMAN

UPF0606 protein KIAA1549L

0.396

IMPG2_HUMAN

Interphotoreceptor matrix proteoglycan 2

0.396

STC1_HUMAN

Stanniocalcin-1

0.396

AKAP6_HUMAN

A-kinase anchor protein 6

0.396

NET4_HUMAN

Netrin-4

0.396

DKK2_HUMAN

Dickkopf-related protein 2

0.396

FNDC1_HUMAN

Fibronectin type III domain-containing protein 1

0.396

HMGX3_HUMAN

HMG domain-containing protein 3

0.396

CD166_HUMAN

CD166 antigen

0.398

GCR_HUMAN

Glucocorticoid receptor

0.398

PTN_HUMAN

Pleiotrophin

0.398

MC4R_HUMAN

Melanocortin receptor 4

0.398

CEP55_HUMAN

Centrosomal protein of 55 kDa

0.398

TPA_HUMAN

Tissue-type plasminogen activator

0.398

TSN18_HUMAN

Tetraspanin-18

0.398

CCD80_HUMAN

Coiled-coil domain-containing protein 80

0.398

CRBA1_HUMAN

Beta-crystallin A3

0.398

LRFN2_HUMAN

Leucine-rich repeat and fibronectin type-III domain-containing protein 2

0.398

ZN142_HUMAN

Zinc finger protein 142

0.398

R4RL1_HUMAN

Reticulon-4 receptor-like 1

0.398

NR0B2_HUMAN

Nuclear receptor subfamily 0 group B member 2

0.398

KLH42_HUMAN

Kelch-like protein 42

0.398

LR75A_HUMAN

Leucine-rich repeat-containing protein 75A

0.398

PKR2_HUMAN

Prokineticin receptor 2

0.398

M3K8_HUMAN

Mitogen-activated protein kinase kinase kinase 8

0.400

ZBTB1_HUMAN

Zinc finger and BTB domain-containing protein 1

0.400

GDNF_HUMAN

Glial cell line-derived neurotrophic factor

0.400

LEPR_HUMAN

Leptin receptor

0.400

HDX_HUMAN

Highly divergent homeobox

0.400

ANGT_HUMAN

Angiotensinogen

0.400

MBP_HUMAN

Myelin basic protein

0.400

PALMD_HUMAN

Palmdelphin

0.400

NLRX1_HUMAN

NLR family member X1

0.400

TMM51_HUMAN

Transmembrane protein 51

0.400

ZBT16_HUMAN

Zinc finger and BTB domain-containing protein 16

0.400

EDAR_HUMAN

Tumor necrosis factor receptor superfamily member EDAR

0.400

PRDM5_HUMAN

PR domain zinc finger protein 5

0.400

ZP3_HUMAN

Zona pellucida sperm-binding protein 3

0.400

VCAM1_HUMAN

Vascular cell adhesion protein 1

0.400

ABEC2_HUMAN

C->U-editing enzyme APOBEC-2

0.400

NYAP2_HUMAN

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

0.400

TANK_HUMAN

TRAF family member-associated NF-kappa-B activator

0.400

CAD17_HUMAN

Cadherin-17

0.400

LYRIC_HUMAN

Protein LYRIC

0.400

TF_HUMAN

Tissue factor

0.400

LRC52_HUMAN

Leucine-rich repeat-containing protein 52

0.400

F131B_HUMAN

Protein FAM131B

0.400

SMS_HUMAN

Somatostatin

0.400

RAG2_HUMAN

V(D)J recombination-activating protein 2

0.400

AKA11_HUMAN

A-kinase anchor protein 11

0.400

SCG3_HUMAN

Secretogranin-3

0.400

LUR1L_HUMAN

Leucine rich adaptor protein 1-like

0.400

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.400

SPIN1_HUMAN

Spindlin-1

0.400

MNAR1_HUMAN

Major intrinsically disordered Notch2-binding receptor 1

0.400

CLD10_HUMAN

Claudin-10

0.400

ZBT18_HUMAN

Zinc finger and BTB domain-containing protein 18

0.400

ZBTB2_HUMAN

Zinc finger and BTB domain-containing protein 2

0.400

DRAXI_HUMAN

Draxin

0.400

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.400

ARL9_HUMAN

ADP-ribosylation factor-like protein 9

0.400

TEFF1_HUMAN

Tomoregulin-1

0.400

PTHR_HUMAN

Parathyroid hormone-related protein

0.400

FPRP_HUMAN

Prostaglandin F2 receptor negative regulator

0.400

LUZP1_HUMAN

Leucine zipper protein 1

0.400

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.400

CDCP1_HUMAN

CUB domain-containing protein 1

0.400

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.400

CXCR4_HUMAN

C-X-C chemokine receptor type 4

0.400

MREG_HUMAN

Melanoregulin

0.400

AZI2_HUMAN

5-azacytidine-induced protein 2

0.400

BFSP1_HUMAN

Filensin

0.400

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 94 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy