AP2C_HUMAN 2019

Gene Name AP2C

Description Transcription factor AP-2 gamma

Length 450

9606

Sequence

>sp|Q92754|AP2C_HUMAN Transcription factor AP-2 gamma
MLWKITDNVKYEEDCEDRHDGSSNGNPRVPHLSSAGQHLYSPAPPLSHTGVAEYQPPPYFPPPYQQLAYSQSADPYSHLGEAYAAAINPLHQPAPTGSQQQAWPGRQSQEGAGLPSHHGRPAGLLPHLSGLEAGAVSARRDAYRRSDLLLPHAHALDAAGLAENLGLHDMPHQMDEVQNVDDQHLLLHDQTVIRKGPISMTKNPLNLPCQKELVGAVMNPTEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKPVAEYLTRPHLGGRNEMAARKNMLLAAQQLCKEFTELLSQDRTPHGTSRLAPVLETNIQNCLSHFSLITHGFGSQAICAAVSALQNYIKEALIVIDKSYMNPGDQSPADSNKTLEKMEKHRK

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

MACOI_HUMAN

Macoilin

0.347

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.352

AP2B_HUMAN

Transcription factor AP-2-beta

0.354

AT1B4_HUMAN

Protein ATP1B4

0.358

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.359

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.362

WLS_HUMAN

Protein wntless homolog

0.365

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.365

TRIO_HUMAN

Triple functional domain protein

0.365

APLP2_HUMAN

Amyloid-like protein 2

0.367

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.367

UNC79_HUMAN

Protein unc-79 homolog

0.367

APC_HUMAN

Adenomatous polyposis coli protein

0.367

AP2A_HUMAN

Transcription factor AP-2-alpha

0.368

BMP2_HUMAN

Bone morphogenetic protein 2

0.370

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.370

HINFP_HUMAN

Histone H4 transcription factor

0.370

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.371

BMP4_HUMAN

Bone morphogenetic protein 4

0.371

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.371

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.371

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.372

CNTP1_HUMAN

Contactin-associated protein 1

0.374

ITB1_HUMAN

Integrin beta-1

0.374

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.376

FERM1_HUMAN

Fermitin family homolog 1

0.377

FERM2_HUMAN

Fermitin family homolog 2

0.377

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.378

CTNA1_HUMAN

Catenin alpha-1

0.378

MADD_HUMAN

MAP kinase-activating death domain protein

0.378

FOXO1_HUMAN

Forkhead box protein O1

0.380

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.381

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.381

RT31_HUMAN

28S ribosomal protein S31, mitochondrial

0.382

NDUBA_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

0.382

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.383

PICK1_HUMAN

PRKCA-binding protein

0.383

MIGA2_HUMAN

Mitoguardin 2

0.383

NUMB_HUMAN

Protein numb homolog

0.383

FOXO3_HUMAN

Forkhead box protein O3

0.383

RIMB2_HUMAN

RIMS-binding protein 2

0.383

TRAK1_HUMAN

Trafficking kinesin-binding protein 1

0.384

ANLN_HUMAN

Anillin

0.384

TSN5_HUMAN

Tetraspanin-5

0.384

TEF_HUMAN

Thyrotroph embryonic factor

0.384

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.384

BICD1_HUMAN

Protein bicaudal D homolog 1

0.384

AFAD_HUMAN

Afadin

0.385

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.386

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.386

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.387

TSHR_HUMAN

Thyrotropin receptor

0.387

ZSWM8_HUMAN

Zinc finger SWIM domain-containing protein 8

0.387

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.388

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.388

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.388

NAB1_HUMAN

NGFI-A-binding protein 1

0.388

SYDE2_HUMAN

Rho GTPase-activating protein SYDE2

0.388

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.389

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.389

MTA1_HUMAN

Metastasis-associated protein MTA1

0.389

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.389

BICD2_HUMAN

Protein bicaudal D homolog 2

0.390

TF3C1_HUMAN

General transcription factor 3C polypeptide 1

0.391

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.391

CSTN1_HUMAN

Calsyntenin-1

0.391

STON1_HUMAN

Stonin-1

0.391

RIPL1_HUMAN

RILP-like protein 1

0.391

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.391

SMAD5_HUMAN

Mothers against decapentaplegic homolog 5

0.392

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.392

AHR_HUMAN

Aryl hydrocarbon receptor

0.392

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.392

ZER1_HUMAN

Protein zer-1 homolog

0.392

PHKG1_HUMAN

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

0.392

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.392

CALRL_HUMAN

Calcitonin gene-related peptide type 1 receptor

0.392

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.393

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.393

ROBO1_HUMAN

Roundabout homolog 1

0.394

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.394

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.394

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.394

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.394

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.395

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.395

VAV2_HUMAN

Guanine nucleotide exchange factor VAV2

0.395

RT22_HUMAN

28S ribosomal protein S22, mitochondrial

0.395

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.395

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.395

FOXO4_HUMAN

Forkhead box protein O4

0.396

BARH2_HUMAN

BarH-like 2 homeobox protein

0.396

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.396

RUND1_HUMAN

RUN domain-containing protein 1

0.396

HTF4_HUMAN

Transcription factor 12

0.396

NAB2_HUMAN

NGFI-A-binding protein 2

0.397

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.397

H6ST2_HUMAN

Heparan-sulfate 6-O-sulfotransferase 2

0.397

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.397

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.397

TFAP4_HUMAN

Transcription factor AP-4

0.397

RUNX3_HUMAN

Runt-related transcription factor 3

0.398

MPDZ_HUMAN

Multiple PDZ domain protein

0.398

RFIP4_HUMAN

Rab11 family-interacting protein 4

0.399

BCL7A_HUMAN

B-cell CLL/lymphoma 7 protein family member A

0.399

P66A_HUMAN

Transcriptional repressor p66-alpha

0.399

TPD54_HUMAN

Tumor protein D54

0.399

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.399

DAB1_HUMAN

Disabled homolog 1

0.399

CSTN3_HUMAN

Calsyntenin-3

0.399

ARFP1_HUMAN

Arfaptin-1

0.399

PXDC2_HUMAN

Plexin domain-containing protein 2

0.400

PAR3L_HUMAN

Partitioning defective 3 homolog B

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 39 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy