BAD_HUMAN 2019

Gene Name BAD

Description Bcl2-associated agonist of cell death

Length 168

9606

Sequence

>sp|Q92934|BAD_HUMAN Bcl2-associated agonist of cell death
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

GRAK_HUMAN

Granzyme K

0.267

GBG1_HUMAN

Guanine nucleotide-binding protein G(T) subunit gamma-T1

0.267

MBPHL_HUMAN

Myosin-binding protein H-like

0.277

EPO_HUMAN

Erythropoietin

0.365

HCAR1_HUMAN

Hydroxycarboxylic acid receptor 1

0.365

GPR4_HUMAN

G-protein coupled receptor 4

0.365

MAZ_HUMAN

Myc-associated zinc finger protein

0.365

CK095_HUMAN

Uncharacterized protein C11orf95

0.365

SLAF7_HUMAN

SLAM family member 7

0.378

TNFB_HUMAN

Lymphotoxin-alpha

0.378

NAT14_HUMAN

N-acetyltransferase 14

0.378

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

EPO_HUMAN

Erythropoietin

0.256

MAG_HUMAN

Myelin-associated glycoprotein

0.314

EMP3_HUMAN

Epithelial membrane protein 3

0.314

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.316

SCN1B_HUMAN

Sodium channel subunit beta-1

0.316

TELT_HUMAN

Telethonin

0.316

NYAP1_HUMAN

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

0.318

TRI44_HUMAN

Tripartite motif-containing protein 44

0.318

FBX50_HUMAN

F-box only protein 50

0.322

GBG1_HUMAN

Guanine nucleotide-binding protein G(T) subunit gamma-T1

0.322

K1C18_HUMAN

Keratin, type I cytoskeletal 18

0.331

EPOR_HUMAN

Erythropoietin receptor

0.333

SPRY4_HUMAN

SPRY domain-containing protein 4

0.333

CC136_HUMAN

Coiled-coil domain-containing protein 136

0.335

CC106_HUMAN

Coiled-coil domain-containing protein 106

0.338

CCG6_HUMAN

Voltage-dependent calcium channel gamma-6 subunit

0.340

T4S5_HUMAN

Transmembrane 4 L6 family member 5

0.342

GRAK_HUMAN

Granzyme K

0.342

IKZF4_HUMAN

Zinc finger protein Eos

0.347

CING_HUMAN

Cingulin

0.349

CN028_HUMAN

Uncharacterized protein C14orf28

0.351

TPSN_HUMAN

Tapasin

0.351

CLD15_HUMAN

Claudin-15

0.354

SE6L2_HUMAN

Seizure 6-like protein 2

0.354

TNFA_HUMAN

Tumor necrosis factor

0.354

TRI27_HUMAN

Zinc finger protein RFP

0.354

RHBD3_HUMAN

Rhomboid domain-containing protein 3

0.354

CRGC_HUMAN

Gamma-crystallin C

0.356

SWAP1_HUMAN

ATPase SWSAP1

0.356

CK095_HUMAN

Uncharacterized protein C11orf95

0.358

SHBG_HUMAN

Sex hormone-binding globulin

0.358

CD79A_HUMAN

B-cell antigen receptor complex-associated protein alpha chain

0.360

LSHB_HUMAN

Lutropin subunit beta

0.360

MBPHL_HUMAN

Myosin-binding protein H-like

0.363

HEMO_HUMAN

Hemopexin

0.364

PROP_HUMAN

Properdin

0.364

THMS2_HUMAN

Protein THEMIS2

0.364

CIART_HUMAN

Circadian-associated transcriptional repressor

0.364

PGS1_HUMAN

Biglycan

0.366

ZN668_HUMAN

Zinc finger protein 668

0.366

DDIT3_HUMAN

DNA damage-inducible transcript 3 protein

0.366

KNCN_HUMAN

Kinocilin

0.368

ECM1_HUMAN

Extracellular matrix protein 1

0.369

CX038_HUMAN

Uncharacterized protein CXorf38

0.369

CXB2_HUMAN

Gap junction beta-2 protein

0.369

TRI11_HUMAN

E3 ubiquitin-protein ligase TRIM11

0.371

NDUA3_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

0.373

CXCR3_HUMAN

C-X-C chemokine receptor type 3

0.376

IGSF8_HUMAN

Immunoglobulin superfamily member 8

0.376

CART_HUMAN

Cocaine- and amphetamine-regulated transcript protein

0.376

K2C8_HUMAN

Keratin, type II cytoskeletal 8

0.376

GPR4_HUMAN

G-protein coupled receptor 4

0.378

S1PBP_HUMAN

S100P-binding protein

0.378

MFAP2_HUMAN

Microfibrillar-associated protein 2

0.378

AINX_HUMAN

Alpha-internexin

0.380

IL19_HUMAN

Interleukin-19

0.380

IL27B_HUMAN

Interleukin-27 subunit beta

0.380

PLP2_HUMAN

Proteolipid protein 2

0.383

STAP2_HUMAN

Signal-transducing adaptor protein 2

0.383

KCP3_HUMAN

Keratinocyte-associated protein 3

0.383

CRUM3_HUMAN

Protein crumbs homolog 3

0.383

SNPC2_HUMAN

snRNA-activating protein complex subunit 2

0.385

EX3L2_HUMAN

Exocyst complex component 3-like protein 2

0.385

MBD1_HUMAN

Methyl-CpG-binding domain protein 1

0.385

APOE_HUMAN

Apolipoprotein E

0.387

DRA_HUMAN

HLA class II histocompatibility antigen, DR alpha chain

0.389

PMEL_HUMAN

Melanocyte protein PMEL

0.389

A0A0G2JMH6_HUMAN

HLA-DRA

0.389

TINF2_HUMAN

TERF1-interacting nuclear factor 2

0.390

CDCA5_HUMAN

Sororin

0.390

HFE_HUMAN

Hereditary hemochromatosis protein

0.390

F131C_HUMAN

Protein FAM131C

0.390

PRRT3_HUMAN

Proline-rich transmembrane protein 3

0.390

JAM1_HUMAN

Junctional adhesion molecule A

0.391

PPR1B_HUMAN

Protein phosphatase 1 regulatory subunit 1B

0.391

APOM_HUMAN

Apolipoprotein M

0.392

NECT2_HUMAN

Nectin-2

0.393

TM160_HUMAN

Transmembrane protein 160

0.395

IGFR1_HUMAN

IGF-like family receptor 1

0.395

NAR5_HUMAN

Ecto-ADP-ribosyltransferase 5

0.396

MYADM_HUMAN

Myeloid-associated differentiation marker

0.398

T178A_HUMAN

Transmembrane protein 178A

0.398

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.398

DSG1_HUMAN

Desmoglein-1

0.398

NAT14_HUMAN

N-acetyltransferase 14

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 13 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy