K1143_HUMAN 2019

Gene Name K1143

Description Uncharacterized protein KIAA1143

Length 154

9606

Sequence

>sp|Q96AT1|K1143_HUMAN Uncharacterized protein KIAA1143
MSKRNQVSYVRPAEPAFLARFKERVGYREGPTVETKRIQPQPPDEDGDHSDKEDEQPQVVVLKKGDLSVEEVMKIKAEIKAAKADEEPTPADGRIIYRKPVKHPSDEKYSGLTASSKKKKPNEDEVNQDSVKKNSQKQIKNSSLLSFDNEDENE

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DAG1_HUMAN

Dystroglycan

0.298

MCF2L_HUMAN

Guanine nucleotide exchange factor DBS

0.302

CEBPG_HUMAN

CCAAT/enhancer-binding protein gamma

0.333

NRF1_HUMAN

Nuclear respiratory factor 1

0.337

NCAM2_HUMAN

Neural cell adhesion molecule 2

0.341

TGFR1_HUMAN

TGF-beta receptor type-1

0.354

STON1_HUMAN

Stonin-1

0.357

E41L5_HUMAN

Band 4.1-like protein 5

0.357

PEBB_HUMAN

Core-binding factor subunit beta

0.361

UNC79_HUMAN

Protein unc-79 homolog

0.361

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.361

KPCD1_HUMAN

Serine/threonine-protein kinase D1

0.361

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.365

UBAP2_HUMAN

Ubiquitin-associated protein 2

0.365

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein

0.365

TSHR_HUMAN

Thyrotropin receptor

0.365

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.365

CC85A_HUMAN

Coiled-coil domain-containing protein 85A

0.369

GTSF1_HUMAN

Gametocyte-specific factor 1

0.369

GDF11_HUMAN

Growth/differentiation factor 11

0.369

SALL1_HUMAN

Sal-like protein 1

0.369

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.369

MTMRA_HUMAN

Myotubularin-related protein 10

0.374

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.374

NCAM1_HUMAN

Neural cell adhesion molecule 1

0.374

FERM1_HUMAN

Fermitin family homolog 1

0.378

FERM2_HUMAN

Fermitin family homolog 2

0.378

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.382

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.382

RUND1_HUMAN

RUN domain-containing protein 1

0.382

EPHA4_HUMAN

Ephrin type-A receptor 4

0.382

HLF_HUMAN

Hepatic leukemia factor

0.382

MACOI_HUMAN

Macoilin

0.382

HTF4_HUMAN

Transcription factor 12

0.382

TRIO_HUMAN

Triple functional domain protein

0.386

AVR2B_HUMAN

Activin receptor type-2B

0.386

RENR_HUMAN

Renin receptor

0.386

RERE_HUMAN

Arginine-glutamic acid dipeptide repeats protein

0.386

INT10_HUMAN

Integrator complex subunit 10

0.386

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.386

STON2_HUMAN

Stonin-2

0.386

APC_HUMAN

Adenomatous polyposis coli protein

0.386

VAS1_HUMAN

V-type proton ATPase subunit S1

0.386

NPC2_HUMAN

NPC intracellular cholesterol transporter 2

0.386

SAV1_HUMAN

Protein salvador homolog 1

0.390

PAR3L_HUMAN

Partitioning defective 3 homolog B

0.390

NPAS3_HUMAN

Neuronal PAS domain-containing protein 3

0.390

PHC2_HUMAN

Polyhomeotic-like protein 2

0.390

NID1_HUMAN

Nidogen-1

0.390

S12A8_HUMAN

Solute carrier family 12 member 8

0.390

GPC1_HUMAN

Glypican-1

0.390

DAB1_HUMAN

Disabled homolog 1

0.390

ETS1_HUMAN

Protein C-ets-1

0.394

JIP2_HUMAN

C-Jun-amino-terminal kinase-interacting protein 2

0.394

NEGR1_HUMAN

Neuronal growth regulator 1

0.394

HES1_HUMAN

Transcription factor HES-1

0.394

BAKOR_HUMAN

Beclin 1-associated autophagy-related key regulator

0.394

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.394

CELR1_HUMAN

Cadherin EGF LAG seven-pass G-type receptor 1

0.394

TMCC3_HUMAN

Transmembrane and coiled-coil domain protein 3

0.394

NF2L1_HUMAN

Endoplasmic reticulum membrane sensor NFE2L1

0.394

TRIB2_HUMAN

Tribbles homolog 2

0.394

GDF8_HUMAN

Growth/differentiation factor 8

0.399

TSN7_HUMAN

Tetraspanin-7

0.399

IRS1_HUMAN

Insulin receptor substrate 1

0.399

SPRC_HUMAN

SPARC

0.399

TLX3_HUMAN

T-cell leukemia homeobox protein 3

0.399

PTN21_HUMAN

Tyrosine-protein phosphatase non-receptor type 21

0.399

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SNAI2_HUMAN

Zinc finger protein SNAI2

0.378

TSHR_HUMAN

Thyrotropin receptor

0.379

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.379

DAG1_HUMAN

Dystroglycan

0.381

K2013_HUMAN

Uncharacterized protein KIAA2013

0.381

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.389

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.391

SAV1_HUMAN

Protein salvador homolog 1

0.391

FERM2_HUMAN

Fermitin family homolog 2

0.393

FERM1_HUMAN

Fermitin family homolog 1

0.393

GO45_HUMAN

Golgin-45

0.394

BAKOR_HUMAN

Beclin 1-associated autophagy-related key regulator

0.395

ANKF1_HUMAN

Ankyrin repeat and fibronectin type-III domain-containing protein 1

0.396

CC85A_HUMAN

Coiled-coil domain-containing protein 85A

0.396

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.398

AT1B4_HUMAN

Protein ATP1B4

0.398

RYK_HUMAN

Tyrosine-protein kinase RYK

0.399

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.399

CEBPG_HUMAN

CCAAT/enhancer-binding protein gamma

0.399

LSHR_HUMAN

Lutropin-choriogonadotropic hormone receptor

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 172 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy