T22D3_HUMAN 2019

Gene Name T22D3

Description TSC22 domain family protein 3

Length 134

9606

Sequence

>sp|Q99576|T22D3_HUMAN TSC22 domain family protein 3
MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVAIDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPEEPAPESPQVPEAPGGSAV

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

T22D2_HUMAN

TSC22 domain family protein 2

0.277

T22D1_HUMAN

TSC22 domain family protein 1

0.320

CTNL1_HUMAN

Alpha-catulin

0.349

AMOT_HUMAN

Angiomotin

0.349

GDF11_HUMAN

Growth/differentiation factor 11

0.349

SALL1_HUMAN

Sal-like protein 1

0.349

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.349

LEG8_HUMAN

Galectin-8

0.349

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.374

NEGR1_HUMAN

Neuronal growth regulator 1

0.378

TMCC3_HUMAN

Transmembrane and coiled-coil domain protein 3

0.378

TMCC2_HUMAN

Transmembrane and coiled-coil domains protein 2

0.383

FER3L_HUMAN

Fer3-like protein

0.387

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

T22D2_HUMAN

TSC22 domain family protein 2

0.267

T22D1_HUMAN

TSC22 domain family protein 1

0.286

LEG8_HUMAN

Galectin-8

0.324

SALL1_HUMAN

Sal-like protein 1

0.330

5HT1A_HUMAN

5-hydroxytryptamine receptor 1A

0.351

FA20C_HUMAN

Extracellular serine/threonine protein kinase FAM20C

0.354

MESD_HUMAN

LRP chaperone MESD

0.357

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.362

CYLD_HUMAN

Ubiquitin carboxyl-terminal hydrolase CYLD

0.362

DAB1_HUMAN

Disabled homolog 1

0.364

TSHR_HUMAN

Thyrotropin receptor

0.364

RT30_HUMAN

39S ribosomal protein S30, mitochondrial

0.365

NAB1_HUMAN

NGFI-A-binding protein 1

0.365

DOXA2_HUMAN

Dual oxidase maturation factor 2

0.365

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.366

SPDEF_HUMAN

SAM pointed domain-containing Ets transcription factor

0.368

CSTN1_HUMAN

Calsyntenin-1

0.368

UNC5D_HUMAN

Netrin receptor UNC5D

0.369

BAG2_HUMAN

BAG family molecular chaperone regulator 2

0.370

UNC5B_HUMAN

Netrin receptor UNC5B

0.370

NRCAM_HUMAN

Neuronal cell adhesion molecule

0.370

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.371

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.372

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.372

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.372

AT1B4_HUMAN

Protein ATP1B4

0.372

MPRIP_HUMAN

Myosin phosphatase Rho-interacting protein

0.374

BARH2_HUMAN

BarH-like 2 homeobox protein

0.374

ANLN_HUMAN

Anillin

0.374

FRS2_HUMAN

Fibroblast growth factor receptor substrate 2

0.375

PRIC2_HUMAN

Prickle-like protein 2

0.375

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.375

CUBN_HUMAN

Cubilin

0.376

SAV1_HUMAN

Protein salvador homolog 1

0.377

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.377

FA43A_HUMAN

Protein FAM43A

0.378

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.378

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.378

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.378

K2013_HUMAN

Uncharacterized protein KIAA2013

0.379

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.379

NEO1_HUMAN

Neogenin

0.380

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.381

ABRA_HUMAN

Actin-binding Rho-activating protein

0.381

SEM6A_HUMAN

Semaphorin-6A

0.381

CTNL1_HUMAN

Alpha-catulin

0.381

PROX1_HUMAN

Prospero homeobox protein 1

0.382

AGRL2_HUMAN

Adhesion G protein-coupled receptor L2

0.382

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.382

SEM6D_HUMAN

Semaphorin-6D

0.383

GULP1_HUMAN

PTB domain-containing engulfment adapter protein 1

0.384

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.384

NID1_HUMAN

Nidogen-1

0.384

HINFP_HUMAN

Histone H4 transcription factor

0.384

BC11A_HUMAN

B-cell lymphoma/leukemia 11A

0.385

DAB2_HUMAN

Disabled homolog 2

0.385

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.385

HES1_HUMAN

Transcription factor HES-1

0.386

LSHR_HUMAN

Lutropin-choriogonadotropic hormone receptor

0.386

KIRR1_HUMAN

Kin of IRRE-like protein 1

0.386

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.386

TEF_HUMAN

Thyrotroph embryonic factor

0.386

TMCC1_HUMAN

Transmembrane and coiled-coil domains protein 1

0.387

NAB2_HUMAN

NGFI-A-binding protein 2

0.387

DOXA1_HUMAN

Dual oxidase maturation factor 1

0.387

DIRA2_HUMAN

GTP-binding protein Di-Ras2

0.387

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.388

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.388

SPRC_HUMAN

SPARC

0.389

TPD54_HUMAN

Tumor protein D54

0.389

CSPG4_HUMAN

Chondroitin sulfate proteoglycan 4

0.389

TMM47_HUMAN

Transmembrane protein 47

0.390

PRDM1_HUMAN

PR domain zinc finger protein 1

0.390

SYDE2_HUMAN

Rho GTPase-activating protein SYDE2

0.390

SUSD2_HUMAN

Sushi domain-containing protein 2

0.390

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.391

TRIO_HUMAN

Triple functional domain protein

0.391

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.392

HLF_HUMAN

Hepatic leukemia factor

0.392

RAB30_HUMAN

Ras-related protein Rab-30

0.392

M3K5_HUMAN

Mitogen-activated protein kinase kinase kinase 5

0.393

ACHA7_HUMAN

Neuronal acetylcholine receptor subunit alpha-7

0.393

RIPL1_HUMAN

RILP-like protein 1

0.393

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.393

LCOR_HUMAN

Ligand-dependent corepressor

0.393

HME2_HUMAN

Homeobox protein engrailed-2

0.393

AP2B_HUMAN

Transcription factor AP-2-beta

0.394

ACK1_HUMAN

Activated CDC42 kinase 1

0.394

FOXO1_HUMAN

Forkhead box protein O1

0.394

ROR1_HUMAN

Inactive tyrosine-protein kinase transmembrane receptor ROR1

0.394

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.394

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.395

PRIC1_HUMAN

Prickle-like protein 1

0.395

KPCD3_HUMAN

Serine/threonine-protein kinase D3

0.395

BMP2_HUMAN

Bone morphogenetic protein 2

0.395

RM51_HUMAN

39S ribosomal protein L51, mitochondrial

0.395

UNC5C_HUMAN

Netrin receptor UNC5C

0.396

TPD52_HUMAN

Tumor protein D52

0.396

NDUBA_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

0.396

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.396

ERBB2_HUMAN

Receptor tyrosine-protein kinase erbB-2

0.397

RYK_HUMAN

Tyrosine-protein kinase RYK

0.397

ACM5_HUMAN

Muscarinic acetylcholine receptor M5

0.397

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.397

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.397

T132E_HUMAN

Transmembrane protein 132E

0.397

SKT_HUMAN

Sickle tail protein homolog

0.398

EPHA4_HUMAN

Ephrin type-A receptor 4

0.398

SARM1_HUMAN

Sterile alpha and TIR motif-containing protein 1

0.398

BICD1_HUMAN

Protein bicaudal D homolog 1

0.398

TSN5_HUMAN

Tetraspanin-5

0.398

OSR2_HUMAN

Protein odd-skipped-related 2

0.399

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.399

MACOI_HUMAN

Macoilin

0.399

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.399

ITB1_HUMAN

Integrin beta-1

0.399

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.399

RABE1_HUMAN

Rab GTPase-binding effector protein 1

0.400

EPHB3_HUMAN

Ephrin type-B receptor 3

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 37 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy