ASPN_HUMAN 2019

Gene Name ASPN

Description Asporin

Length 380

9606

Sequence

>sp|Q9BXN1|ASPN_HUMAN Asporin
MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPATFRCVLSRMSVQLGNFGM

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

A0A3B3IU46_HUMAN

RNA guanine-7 methyltransferase-activating subunit-like (pseudogene)

0.236

KCNE2_HUMAN

Potassium voltage-gated channel subfamily E member 2

0.243

CD3E_HUMAN

T-cell surface glycoprotein CD3 epsilon chain

0.243

BCLA3_HUMAN

BCLAF1 and THRAP3 family member 3

0.243

NOBOX_HUMAN

Homeobox protein NOBOX

0.243

CEFIP_HUMAN

Cardiac-enriched FHL2-interacting protein

0.243

PPR26_HUMAN

Protein phosphatase 1 regulatory subunit 26

0.243

PCD17_HUMAN

Protocadherin-17

0.324

E4F1_HUMAN

Transcription factor E4F1

0.324

CAHM3_HUMAN

Calcium homeostasis modulator protein 3

0.333

LRC19_HUMAN

Leucine-rich repeat-containing protein 19

0.333

IL1R2_HUMAN

Interleukin-1 receptor type 2

0.333

C1QA_HUMAN

Complement C1q subcomponent subunit A

0.333

RAMAC_HUMAN

RNA guanine-N7 methyltransferase activating subunit

0.333

COX7B_HUMAN

Cytochrome c oxidase subunit 7B, mitochondrial

0.333

ETAA1_HUMAN

Ewings tumor-associated antigen 1

0.333

CCGL_HUMAN

Voltage-dependent calcium channel gamma-like subunit

0.333

UIF_HUMAN

UAP56-interacting factor

0.333

T3JAM_HUMAN

TRAF3-interacting JNK-activating modulator

0.333

TM159_HUMAN

Promethin

0.333

MANS1_HUMAN

MANSC domain-containing protein 1

0.333

PRSR2_HUMAN

Proline and serine-rich protein 2

0.333

TCFL5_HUMAN

Transcription factor-like 5 protein

0.333

MLIP_HUMAN

Muscular LMNA-interacting protein

0.333

ZN365_HUMAN

Protein ZNF365

0.333

FA83A_HUMAN

Protein FAM83A

0.333

CU062_HUMAN

Uncharacterized protein C21orf62

0.343

IL6_HUMAN

Interleukin-6

0.343

CD6_HUMAN

T-cell differentiation antigen CD6

0.343

MAMD1_HUMAN

Mastermind-like domain-containing protein 1

0.343

INY2B_HUMAN

Protein INSYN2B

0.343

PRR29_HUMAN

Proline-rich protein 29

0.343

SYBU_HUMAN

Syntabulin

0.387

ATL2_HUMAN

ADAMTS-like protein 2

0.387

GPR12_HUMAN

G-protein coupled receptor 12

0.387

IBP1_HUMAN

Insulin-like growth factor-binding protein 1

0.387

IL17_HUMAN

Interleukin-17A

0.387

CC172_HUMAN

Coiled-coil domain-containing protein 172

0.387

PRGR_HUMAN

Progesterone receptor

0.397

AZI2_HUMAN

5-azacytidine-induced protein 2

0.397

SYT13_HUMAN

Synaptotagmin-13

0.397

DSG2_HUMAN

Desmoglein-2

0.397

IGSF3_HUMAN

Immunoglobulin superfamily member 3

0.397

C99L2_HUMAN

CD99 antigen-like protein 2

0.397

CD44_HUMAN

CD44 antigen

0.397

NMI_HUMAN

N-myc-interactor

0.397

SNN_HUMAN

Stannin

0.397

R51A1_HUMAN

RAD51-associated protein 1

0.397

C2TA_HUMAN

MHC class II transactivator

0.397

F1892_HUMAN

Protein FAM189A2

0.397

CD3Z_HUMAN

T-cell surface glycoprotein CD3 zeta chain

0.397

JCAD_HUMAN

Junctional protein associated with coronary artery disease

0.397

CD3G_HUMAN

T-cell surface glycoprotein CD3 gamma chain

0.397

IL21R_HUMAN

Interleukin-21 receptor

0.397

CO039_HUMAN

Uncharacterized protein C15orf39

0.397

ZN638_HUMAN

Zinc finger protein 638

0.397

GP149_HUMAN

Probable G-protein coupled receptor 149

0.397

PECA1_HUMAN

Platelet endothelial cell adhesion molecule

0.397

MAP9_HUMAN

Microtubule-associated protein 9

0.397

GOGB1_HUMAN

Golgin subfamily B member 1

0.397

COGA1_HUMAN

Collagen alpha-1(XVI) chain

0.397

ZBTB5_HUMAN

Zinc finger and BTB domain-containing protein 5

0.397

MRP_HUMAN

MARCKS-related protein

0.397

APC16_HUMAN

Anaphase-promoting complex subunit 16

0.397

EDN1_HUMAN

Endothelin-1

0.397

NHLC1_HUMAN

E3 ubiquitin-protein ligase NHLRC1

0.397

CMGA_HUMAN

Chromogranin-A

0.397

PTGDS_HUMAN

Prostaglandin-H2 D-isomerase

0.397

CXL14_HUMAN

C-X-C motif chemokine 14

0.397

SETBP_HUMAN

SET-binding protein

0.397

CQ058_HUMAN

UPF0450 protein C17orf58

0.397

AHDC1_HUMAN

AT-hook DNA-binding motif-containing protein 1

0.397

CX021_HUMAN

Uncharacterized protein CXorf21

0.397

FGF23_HUMAN

Fibroblast growth factor 23

0.397

NUCKS_HUMAN

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

0.397

GLPC_HUMAN

Glycophorin-C

0.397

CXCR5_HUMAN

C-X-C chemokine receptor type 5

0.397

AKP8L_HUMAN

A-kinase anchor protein 8-like

0.397

IL10_HUMAN

Interleukin-10

0.397

MYNN_HUMAN

Myoneurin

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TM252_HUMAN

Transmembrane protein 252

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 17 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy