LRRC3_HUMAN 2019

Gene Name LRRC3

Description Leucine-rich repeat-containing protein 3

Length 257

9606

Sequence

>sp|Q9BY71|LRRC3_HUMAN Leucine-rich repeat-containing protein 3
MGTVRPPRPSLLLVSTRESCLFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEFVGKPLVQALDAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYLKSLPSAPASKDPIGPGP

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NKPD1_HUMAN

NTPase KAP family P-loop domain-containing protein 1

0.000

ZHX2_HUMAN

Zinc fingers and homeoboxes protein 2

0.224

K2C8_HUMAN

Keratin, type II cytoskeletal 8

0.229

EMP3_HUMAN

Epithelial membrane protein 3

0.229

ZBT37_HUMAN

Zinc finger and BTB domain-containing protein 37

0.309

MACC1_HUMAN

Metastasis-associated in colon cancer protein 1

0.309

SH3B4_HUMAN

SH3 domain-binding protein 4

0.309

STC1_HUMAN

Stanniocalcin-1

0.309

RAMP1_HUMAN

Receptor activity-modifying protein 1

0.316

PI3R6_HUMAN

Phosphoinositide 3-kinase regulatory subunit 6

0.316

SHL2A_HUMAN

Protein shisa-like-2A

0.316

S3TC2_HUMAN

SH3 domain and tetratricopeptide repeat-containing protein 2

0.316

RGR_HUMAN

RPE-retinal G protein-coupled receptor

0.316

MYADM_HUMAN

Myeloid-associated differentiation marker

0.324

S1PR1_HUMAN

Sphingosine 1-phosphate receptor 1

0.369

LPAR1_HUMAN

Lysophosphatidic acid receptor 1

0.369

DKK2_HUMAN

Dickkopf-related protein 2

0.369

CNMD_HUMAN

Leukocyte cell-derived chemotaxin 1

0.369

MASP1_HUMAN

Mannan-binding lectin serine protease 1

0.369

LFTY1_HUMAN

Left-right determination factor 1

0.369

STC2_HUMAN

Stanniocalcin-2

0.369

I17RA_HUMAN

Interleukin-17 receptor A

0.369

LRC3B_HUMAN

Leucine-rich repeat-containing protein 3B

0.369

T126A_HUMAN

Transmembrane protein 126A

0.369

LFTY2_HUMAN

Left-right determination factor 2

0.369

NET4_HUMAN

Netrin-4

0.369

EFNA5_HUMAN

Ephrin-A5

0.378

STXB6_HUMAN

Syntaxin-binding protein 6

0.378

T255A_HUMAN

Transmembrane protein 255A

0.378

NTNG1_HUMAN

Netrin-G1

0.378

T150A_HUMAN

Transmembrane protein 150A

0.378

RFXAP_HUMAN

Regulatory factor X-associated protein

0.378

CCDC3_HUMAN

Coiled-coil domain-containing protein 3

0.378

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.378

MUC18_HUMAN

Cell surface glycoprotein MUC18

0.378

DLK2_HUMAN

Protein delta homolog 2

0.378

I10R2_HUMAN

Interleukin-10 receptor subunit beta

0.378

BCL6_HUMAN

B-cell lymphoma 6 protein

0.378

BORG2_HUMAN

Cdc42 effector protein 3

0.378

CRBA1_HUMAN

Beta-crystallin A3

0.378

CD166_HUMAN

CD166 antigen

0.378

PRLHR_HUMAN

Prolactin-releasing peptide receptor

0.378

PRLR_HUMAN

Prolactin receptor

0.378

RLF_HUMAN

Zinc finger protein Rlf

0.378

R4RL1_HUMAN

Reticulon-4 receptor-like 1

0.378

EFCC1_HUMAN

EF-hand and coiled-coil domain-containing protein 1

0.378

C2C4C_HUMAN

C2 calcium-dependent domain-containing protein 4C

0.378

CALD1_HUMAN

Caldesmon

0.378

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.378

TSN18_HUMAN

Tetraspanin-18

0.378

RAMP3_HUMAN

Receptor activity-modifying protein 3

0.378

PTN_HUMAN

Pleiotrophin

0.378

ZN148_HUMAN

Zinc finger protein 148

0.378

GAK1B_HUMAN

Golgi-associated kinase 1B

0.378

SCG3_HUMAN

Secretogranin-3

0.378

SLIK5_HUMAN

SLIT and NTRK-like protein 5

0.378

EDNRB_HUMAN

Endothelin receptor type B

0.378

LARGN_HUMAN

Protein Largen

0.378

HBAZ_HUMAN

Hemoglobin subunit zeta

0.378

EDNRA_HUMAN

Endothelin-1 receptor

0.378

SLIK6_HUMAN

SLIT and NTRK-like protein 6

0.378

PGBD5_HUMAN

PiggyBac transposable element-derived protein 5

0.378

FBLN7_HUMAN

Fibulin-7

0.378

GPC5B_HUMAN

G-protein coupled receptor family C group 5 member B

0.378

TPA_HUMAN

Tissue-type plasminogen activator

0.378

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.378

ZN142_HUMAN

Zinc finger protein 142

0.378

EURL_HUMAN

Protein EURL homolog

0.378

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.378

AKAP2_HUMAN

A-kinase anchor protein 2

0.378

GT2D1_HUMAN

General transcription factor II-I repeat domain-containing protein 1

0.378

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.378

PKR1_HUMAN

Prokineticin receptor 1

0.378

FLIP1_HUMAN

Filamin-A-interacting protein 1

0.378

T178A_HUMAN

Transmembrane protein 178A

0.387

ESAM_HUMAN

Endothelial cell-selective adhesion molecule

0.387

SPRY4_HUMAN

SPRY domain-containing protein 4

0.387

HECA2_HUMAN

HEPACAM family member 2

0.387

ZBT22_HUMAN

Zinc finger and BTB domain-containing protein 22

0.387

T150B_HUMAN

Modulator of macroautophagy TMEM150B

0.387

EVPL_HUMAN

Envoplakin

0.387

GAK1A_HUMAN

Golgi-associated kinase 1A

0.387

BT1A1_HUMAN

Butyrophilin subfamily 1 member A1

0.387

K1C18_HUMAN

Keratin, type I cytoskeletal 18

0.387

HXC13_HUMAN

Homeobox protein Hox-C13

0.387

CRBA4_HUMAN

Beta-crystallin A4

0.387

SLIK2_HUMAN

SLIT and NTRK-like protein 2

0.387

LSR_HUMAN

Lipolysis-stimulated lipoprotein receptor

0.387

OCSTP_HUMAN

Osteoclast stimulatory transmembrane protein

0.387

EPOR_HUMAN

Erythropoietin receptor

0.387

ASC_HUMAN

Apoptosis-associated speck-like protein containing a CARD

0.387

PERF_HUMAN

Perforin-1

0.387

CLUS_HUMAN

Clusterin

0.387

FETUB_HUMAN

Fetuin-B

0.387

CALCB_HUMAN

Calcitonin gene-related peptide 2

0.387

ZN319_HUMAN

Zinc finger protein 319

0.387

TM240_HUMAN

Transmembrane protein 240

0.387

CML1_HUMAN

Chemokine-like receptor 1

0.387

PDYN_HUMAN

Proenkephalin-B

0.387

K1C14_HUMAN

Keratin, type I cytoskeletal 14

0.387

BTC_HUMAN

Probetacellulin

0.387

TMG4_HUMAN

Transmembrane gamma-carboxyglutamic acid protein 4

0.387

CHP3_HUMAN

Calcineurin B homologous protein 3

0.387

CRGC_HUMAN

Gamma-crystallin C

0.387

CAD26_HUMAN

Cadherin-like protein 26

0.387

CRBA2_HUMAN

Beta-crystallin A2

0.387

MAG_HUMAN

Myelin-associated glycoprotein

0.387

SIG15_HUMAN

Sialic acid-binding Ig-like lectin 15

0.387

CALC_HUMAN

Calcitonin

0.387

GPR17_HUMAN

Uracil nucleotide/cysteinyl leukotriene receptor

0.387

MPZL1_HUMAN

Myelin protein zero-like protein 1

0.387

SCAR3_HUMAN

Scavenger receptor class A member 3

0.387

CX038_HUMAN

Uncharacterized protein CXorf38

0.387

CRGA_HUMAN

Gamma-crystallin A

0.397

BL1S3_HUMAN

Biogenesis of lysosome-related organelles complex 1 subunit 3

0.397

CXCR3_HUMAN

C-X-C chemokine receptor type 3

0.397

GPR25_HUMAN

Probable G-protein coupled receptor 25

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

MYADM_HUMAN

Myeloid-associated differentiation marker

0.329

STC2_HUMAN

Stanniocalcin-2

0.388

SH3B4_HUMAN

SH3 domain-binding protein 4

0.388

CO6A2_HUMAN

Collagen alpha-2(VI) chain

0.392

ESAM_HUMAN

Endothelial cell-selective adhesion molecule

0.392

APOH_HUMAN

Beta-2-glycoprotein 1

0.392

TMM74_HUMAN

Transmembrane protein 74

0.394

ZHX2_HUMAN

Zinc fingers and homeoboxes protein 2

0.397

PTAFR_HUMAN

Platelet-activating factor receptor

0.397

TMM25_HUMAN

Transmembrane protein 25

0.397

NET4_HUMAN

Netrin-4

0.399

STC1_HUMAN

Stanniocalcin-1

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 19 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy