RTN4R_HUMAN 2019

Gene Name RTN4R

Description Reticulon-4 receptor

Length 473

9606

Sequence

>sp|Q9BZR6|RTN4R_HUMAN Reticulon-4 receptor
MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

FETUB_HUMAN

Fetuin-B

0.370

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.370

ZN148_HUMAN

Zinc finger protein 148

0.370

GDF9_HUMAN

Growth/differentiation factor 9

0.370

CAVN2_HUMAN

Caveolae-associated protein 2

0.370

BRI3B_HUMAN

BRI3-binding protein

0.372

HMGX3_HUMAN

HMG domain-containing protein 3

0.378

MC4R_HUMAN

Melanocortin receptor 4

0.380

GCR_HUMAN

Glucocorticoid receptor

0.380

FMOD_HUMAN

Fibromodulin

0.382

CCR7_HUMAN

C-C chemokine receptor type 7

0.382

CDCP1_HUMAN

CUB domain-containing protein 1

0.382

LRC52_HUMAN

Leucine-rich repeat-containing protein 52

0.382

TMM51_HUMAN

Transmembrane protein 51

0.382

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.382

ZP3_HUMAN

Zona pellucida sperm-binding protein 3

0.382

ANGT_HUMAN

Angiotensinogen

0.382

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.382

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.382

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.382

CXD2_HUMAN

Gap junction delta-2 protein

0.382

SPIN1_HUMAN

Spindlin-1

0.382

CLD11_HUMAN

Claudin-11

0.382

ZN335_HUMAN

Zinc finger protein 335

0.382

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.382

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.382

SYNCI_HUMAN

Syncoilin

0.384

OGR1_HUMAN

Ovarian cancer G-protein coupled receptor 1

0.384

MLC1_HUMAN

Membrane protein MLC1

0.384

XK_HUMAN

Membrane transport protein XK

0.384

PCD10_HUMAN

Protocadherin-10

0.384

CXL14_HUMAN

C-X-C motif chemokine 14

0.384

OX2G_HUMAN

OX-2 membrane glycoprotein

0.384

ZN711_HUMAN

Zinc finger protein 711

0.384

ZBT26_HUMAN

Zinc finger and BTB domain-containing protein 26

0.384

PACA_HUMAN

Pituitary adenylate cyclase-activating polypeptide

0.384

EDAD_HUMAN

Ectodysplasin-A receptor-associated adapter protein

0.386

PANX1_HUMAN

Pannexin-1

0.389

HSPB8_HUMAN

Heat shock protein beta-8

0.389

CCG1_HUMAN

Voltage-dependent calcium channel gamma-1 subunit

0.391

STC2_HUMAN

Stanniocalcin-2

0.391

EURL_HUMAN

Protein EURL homolog

0.391

CXAR_HUMAN

Coxsackievirus and adenovirus receptor

0.391

GAK1B_HUMAN

Golgi-associated kinase 1B

0.391

ZN644_HUMAN

Zinc finger protein 644

0.393

GHR_HUMAN

Growth hormone receptor

0.393

TR19L_HUMAN

Tumor necrosis factor receptor superfamily member 19L

0.393

NPY_HUMAN

Pro-neuropeptide Y

0.393

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.393

LARGN_HUMAN

Protein Largen

0.393

ZN131_HUMAN

Zinc finger protein 131

0.393

STYK1_HUMAN

Tyrosine-protein kinase STYK1

0.393

LEG1_HUMAN

Galectin-1

0.393

MERB1_HUMAN

bMERB domain-containing protein 1

0.393

CALD1_HUMAN

Caldesmon

0.393

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.393

PRL_HUMAN

Prolactin

0.393

PENK_HUMAN

Proenkephalin-A

0.393

OCLN_HUMAN

Occludin

0.393

MYZAP_HUMAN

Myocardial zonula adherens protein

0.393

NEXMI_HUMAN

Neurite extension and migration factor

0.393

PCD19_HUMAN

Protocadherin-19

0.393

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.393

PDGFC_HUMAN

Platelet-derived growth factor C

0.393

RLF_HUMAN

Zinc finger protein Rlf

0.393

ASTN1_HUMAN

Astrotactin-1

0.393

CRBB1_HUMAN

Beta-crystallin B1

0.393

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.393

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.393

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.393

SYBU_HUMAN

Syntabulin

0.393

ERRFI_HUMAN

ERBB receptor feedback inhibitor 1

0.395

ZN652_HUMAN

Zinc finger protein 652

0.395

EVPL_HUMAN

Envoplakin

0.395

BSPRY_HUMAN

B box and SPRY domain-containing protein

0.395

TSG6_HUMAN

Tumor necrosis factor-inducible gene 6 protein

0.395

SUSD6_HUMAN

Sushi domain-containing protein 6

0.395

CC126_HUMAN

Coiled-coil domain-containing protein 126

0.395

CMGA_HUMAN

Chromogranin-A

0.395

ACKR3_HUMAN

Atypical chemokine receptor 3

0.395

PEPL_HUMAN

Periplakin

0.395

BAG5_HUMAN

BAG family molecular chaperone regulator 5

0.395

HECAM_HUMAN

Hepatocyte cell adhesion molecule

0.395

K1549_HUMAN

UPF0606 protein KIAA1549

0.395

IL17_HUMAN

Interleukin-17A

0.395

F222B_HUMAN

Protein FAM222B

0.395

IKIP_HUMAN

Inhibitor of nuclear factor kappa-B kinase-interacting protein

0.395

F168A_HUMAN

Protein FAM168A

0.395

SOGA1_HUMAN

Protein SOGA1

0.395

MFR1L_HUMAN

Mitochondrial fission regulator 1-like

0.395

MRAP2_HUMAN

Melanocortin-2 receptor accessory protein 2

0.395

ZBT20_HUMAN

Zinc finger and BTB domain-containing protein 20

0.395

TSN1_HUMAN

Tetraspanin-1

0.395

OLFL3_HUMAN

Olfactomedin-like protein 3

0.395

NRN1_HUMAN

Neuritin

0.397

CLMP_HUMAN

CXADR-like membrane protein

0.397

BRNP1_HUMAN

BMP/retinoic acid-inducible neural-specific protein 1

0.397

TAC2N_HUMAN

Tandem C2 domains nuclear protein

0.397

SMPX_HUMAN

Small muscular protein

0.397

ZBT25_HUMAN

Zinc finger and BTB domain-containing protein 25

0.397

K1522_HUMAN

Uncharacterized protein KIAA1522

0.397

SUSD3_HUMAN

Sushi domain-containing protein 3

0.397

VTM2L_HUMAN

V-set and transmembrane domain-containing protein 2-like protein

0.397

AF1L1_HUMAN

Actin filament-associated protein 1-like 1

0.398

AF1L2_HUMAN

Actin filament-associated protein 1-like 2

0.398

PCD18_HUMAN

Protocadherin-18

0.400

HPLN1_HUMAN

Hyaluronan and proteoglycan link protein 1

0.400

RET4_HUMAN

Retinol-binding protein 4

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 20 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy