TINAL_HUMAN 2019

Gene Name TINAL

Description Tubulointerstitial nephritis antigen-like

Length 467

9606

Sequence

>sp|Q9GZM7|TINAL_HUMAN Tubulointerstitial nephritis antigen-like
MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SPRC_HUMAN

SPARC

0.345

LEG8_HUMAN

Galectin-8

0.374

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.383

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

LEG8_HUMAN

Galectin-8

0.321

BAG2_HUMAN

BAG family molecular chaperone regulator 2

0.324

SPRC_HUMAN

SPARC

0.360

CUBN_HUMAN

Cubilin

0.361

DOXA2_HUMAN

Dual oxidase maturation factor 2

0.362

RM51_HUMAN

39S ribosomal protein L51, mitochondrial

0.367

GULP1_HUMAN

PTB domain-containing engulfment adapter protein 1

0.368

MPRIP_HUMAN

Myosin phosphatase Rho-interacting protein

0.371

RIN2_HUMAN

Ras and Rab interactor 2

0.371

5HT1B_HUMAN

5-hydroxytryptamine receptor 1B

0.373

TMM47_HUMAN

Transmembrane protein 47

0.374

KIRR3_HUMAN

Kin of IRRE-like protein 3

0.374

5HT1A_HUMAN

5-hydroxytryptamine receptor 1A

0.374

SGCE_HUMAN

Epsilon-sarcoglycan

0.375

EGFR_HUMAN

Epidermal growth factor receptor

0.375

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.375

NEO1_HUMAN

Neogenin

0.377

SPDEF_HUMAN

SAM pointed domain-containing Ets transcription factor

0.378

FA20C_HUMAN

Extracellular serine/threonine protein kinase FAM20C

0.378

SRCN1_HUMAN

SRC kinase signaling inhibitor 1

0.379

SALL1_HUMAN

Sal-like protein 1

0.381

KIRR1_HUMAN

Kin of IRRE-like protein 1

0.383

SKT_HUMAN

Sickle tail protein homolog

0.383

SARM1_HUMAN

Sterile alpha and TIR motif-containing protein 1

0.383

PRIC2_HUMAN

Prickle-like protein 2

0.384

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.384

MACOI_HUMAN

Macoilin

0.384

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.385

TSHR_HUMAN

Thyrotropin receptor

0.386

RORA_HUMAN

Nuclear receptor ROR-alpha

0.387

RT30_HUMAN

39S ribosomal protein S30, mitochondrial

0.387

PRDM1_HUMAN

PR domain zinc finger protein 1

0.387

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.388

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.388

TPD53_HUMAN

Tumor protein D53

0.388

CRUM1_HUMAN

Protein crumbs homolog 1

0.389

CHSS2_HUMAN

Chondroitin sulfate synthase 2

0.389

CSTN1_HUMAN

Calsyntenin-1

0.390

RIPL1_HUMAN

RILP-like protein 1

0.390

SEM6A_HUMAN

Semaphorin-6A

0.390

HME2_HUMAN

Homeobox protein engrailed-2

0.390

PROX1_HUMAN

Prospero homeobox protein 1

0.391

UNC5D_HUMAN

Netrin receptor UNC5D

0.391

ANKF1_HUMAN

Ankyrin repeat and fibronectin type-III domain-containing protein 1

0.391

RORB_HUMAN

Nuclear receptor ROR-beta

0.391

CALRL_HUMAN

Calcitonin gene-related peptide type 1 receptor

0.391

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.392

MESD_HUMAN

LRP chaperone MESD

0.392

NRCAM_HUMAN

Neuronal cell adhesion molecule

0.392

SEM6D_HUMAN

Semaphorin-6D

0.392

TPD52_HUMAN

Tumor protein D52

0.393

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.393

RBCC1_HUMAN

RB1-inducible coiled-coil protein 1

0.393

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.393

AT1B4_HUMAN

Protein ATP1B4

0.393

ERBB2_HUMAN

Receptor tyrosine-protein kinase erbB-2

0.394

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.394

T132E_HUMAN

Transmembrane protein 132E

0.394

TX1B3_HUMAN

Tax1-binding protein 3

0.394

TEF_HUMAN

Thyrotroph embryonic factor

0.395

TTC17_HUMAN

Tetratricopeptide repeat protein 17

0.395

TSN5_HUMAN

Tetraspanin-5

0.395

DOXA1_HUMAN

Dual oxidase maturation factor 1

0.396

CRYA2_HUMAN

Alpha-crystallin A2 chain

0.396

TMCC1_HUMAN

Transmembrane and coiled-coil domains protein 1

0.396

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.397

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.397

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.398

TPD54_HUMAN

Tumor protein D54

0.398

CSPG4_HUMAN

Chondroitin sulfate proteoglycan 4

0.398

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.398

SAV1_HUMAN

Protein salvador homolog 1

0.398

DAB1_HUMAN

Disabled homolog 1

0.398

MYT1_HUMAN

Myelin transcription factor 1

0.398

ALK_HUMAN

ALK tyrosine kinase receptor

0.399

T22D2_HUMAN

TSC22 domain family protein 2

0.399

PDZD8_HUMAN

PDZ domain-containing protein 8

0.399

SUSD2_HUMAN

Sushi domain-containing protein 2

0.399

TRIO_HUMAN

Triple functional domain protein

0.399

FA43A_HUMAN

Protein FAM43A

0.400

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.400

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.400

DAG1_HUMAN

Dystroglycan

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 40 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy