HPLN2_HUMAN 2019

Gene Name HPLN2

Description Hyaluronan and proteoglycan link protein 2

Length 340

9606

Sequence

>sp|Q9GZV7|HPLN2_HUMAN Hyaluronan and proteoglycan link protein 2
MPGWLTLPTLCRFLLWAFTIFHKAQGDPASHPGPHYLLPPIHEVIHSHRGATATLPCVLGTTPPSYKVRWSKVEPGELRETLILITNGLHARGYGPLGGRARMRRGHRLDASLVIAGVRLEDEGRYRCELINGIEDESVALTLSLEGVVFPYQPSRGRYQFNYYEAKQACEEQDGRLATYSQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGGRGRPGIRSYGPRDRMRDRYDAFCFTSALAGQVFFVPGRLTLSEAHAACRRRGAVVAKVGHLYAAWKFSGLDQCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSFGFPRPQQAAYGTYCYAEN

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

HPLN4_HUMAN

Hyaluronan and proteoglycan link protein 4

0.224

RHNO1_HUMAN

RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

0.229

VEGFC_HUMAN

Vascular endothelial growth factor C

0.309

F1891_HUMAN

Protein FAM189A1

0.309

LR14B_HUMAN

Leucine-rich repeat-containing protein 14B

0.309

HPLN1_HUMAN

Hyaluronan and proteoglycan link protein 1

0.309

HMGX3_HUMAN

HMG domain-containing protein 3

0.309

NCAN_HUMAN

Neurocan core protein

0.309

SOCS3_HUMAN

Suppressor of cytokine signaling 3

0.316

HPLN3_HUMAN

Hyaluronan and proteoglycan link protein 3

0.316

CD276_HUMAN

CD276 antigen

0.316

ZBT8B_HUMAN

Zinc finger and BTB domain-containing protein 8B

0.316

SOGA1_HUMAN

Protein SOGA1

0.316

TGFA_HUMAN

Protransforming growth factor alpha

0.316

ATL5_HUMAN

ADAMTS-like protein 5

0.316

LRC38_HUMAN

Leucine-rich repeat-containing protein 38

0.316

INSY1_HUMAN

Inhibitory synaptic factor 1

0.316

PAQR9_HUMAN

Membrane progestin receptor epsilon

0.316

BRNP3_HUMAN

BMP/retinoic acid-inducible neural-specific protein 3

0.316

SNPC5_HUMAN

snRNA-activating protein complex subunit 5

0.316

STYK1_HUMAN

Tyrosine-protein kinase STYK1

0.316

CRBB1_HUMAN

Beta-crystallin B1

0.316

MN1_HUMAN

Transcriptional activator MN1

0.324

MALD2_HUMAN

MARVEL domain-containing protein 2

0.324

ADML_HUMAN

ADM

0.324

PPR1B_HUMAN

Protein phosphatase 1 regulatory subunit 1B

0.324

VTCN1_HUMAN

V-set domain-containing T-cell activation inhibitor 1

0.324

PEA15_HUMAN

Astrocytic phosphoprotein PEA-15

0.369

FADS6_HUMAN

Fatty acid desaturase 6

0.369

HNMT_HUMAN

Histamine N-methyltransferase

0.369

MASP1_HUMAN

Mannan-binding lectin serine protease 1

0.369

PIT1_HUMAN

Pituitary-specific positive transcription factor 1

0.369

PKR2_HUMAN

Prokineticin receptor 2

0.369

PTN_HUMAN

Pleiotrophin

0.378

ZN148_HUMAN

Zinc finger protein 148

0.378

I10R2_HUMAN

Interleukin-10 receptor subunit beta

0.378

GAK1B_HUMAN

Golgi-associated kinase 1B

0.378

EDAR_HUMAN

Tumor necrosis factor receptor superfamily member EDAR

0.378

RET2_HUMAN

Retinol-binding protein 2

0.378

SCG3_HUMAN

Secretogranin-3

0.378

F181A_HUMAN

Protein FAM181A

0.378

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.378

TR19L_HUMAN

Tumor necrosis factor receptor superfamily member 19L

0.378

GP153_HUMAN

Probable G-protein coupled receptor 153

0.378

TPA_HUMAN

Tissue-type plasminogen activator

0.378

CRBA1_HUMAN

Beta-crystallin A3

0.378

GPR26_HUMAN

G-protein coupled receptor 26

0.378

TM116_HUMAN

Transmembrane protein 116

0.378

EDNRB_HUMAN

Endothelin receptor type B

0.378

LARGN_HUMAN

Protein Largen

0.378

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.378

SCAR5_HUMAN

Scavenger receptor class A member 5

0.378

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.378

HBAZ_HUMAN

Hemoglobin subunit zeta

0.378

NR0B1_HUMAN

Nuclear receptor subfamily 0 group B member 1

0.378

RFXAP_HUMAN

Regulatory factor X-associated protein

0.378

PRLHR_HUMAN

Prolactin-releasing peptide receptor

0.378

EDNRA_HUMAN

Endothelin-1 receptor

0.378

CCDC3_HUMAN

Coiled-coil domain-containing protein 3

0.378

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.378

PGBD5_HUMAN

PiggyBac transposable element-derived protein 5

0.378

FIGLA_HUMAN

Factor in the germline alpha

0.378

MC4R_HUMAN

Melanocortin receptor 4

0.378

TSN18_HUMAN

Tetraspanin-18

0.378

PRLR_HUMAN

Prolactin receptor

0.378

TNIP2_HUMAN

TNFAIP3-interacting protein 2

0.378

RAMP3_HUMAN

Receptor activity-modifying protein 3

0.378

RLF_HUMAN

Zinc finger protein Rlf

0.378

EFCC1_HUMAN

EF-hand and coiled-coil domain-containing protein 1

0.378

T255A_HUMAN

Transmembrane protein 255A

0.378

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.378

C2C4C_HUMAN

C2 calcium-dependent domain-containing protein 4C

0.378

EURL_HUMAN

Protein EURL homolog

0.378

CAHM1_HUMAN

Calcium homeostasis modulator protein 1

0.378

CYTL1_HUMAN

Cytokine-like protein 1

0.387

HIC2_HUMAN

Hypermethylated in cancer 2 protein

0.387

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.387

CNRG_HUMAN

Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.387

SRPX2_HUMAN

Sushi repeat-containing protein SRPX2

0.387

FA83C_HUMAN

Protein FAM83C

0.387

CAVN4_HUMAN

Caveolae-associated protein 4

0.387

F222A_HUMAN

Protein FAM222A

0.387

F189B_HUMAN

Protein FAM189B

0.387

ZN513_HUMAN

Zinc finger protein 513

0.387

CART_HUMAN

Cocaine- and amphetamine-regulated transcript protein

0.387

P3IP1_HUMAN

Phosphoinositide-3-kinase-interacting protein 1

0.387

HXA13_HUMAN

Homeobox protein Hox-A13

0.387

PCD19_HUMAN

Protocadherin-19

0.387

PRR35_HUMAN

Proline-rich protein 35

0.387

HEG1_HUMAN

Protein HEG homolog 1

0.387

IBP2_HUMAN

Insulin-like growth factor-binding protein 2

0.387

K1671_HUMAN

Uncharacterized protein KIAA1671

0.387

CCD30_HUMAN

Coiled-coil domain-containing protein 30

0.387

CPLX3_HUMAN

Complexin-3

0.387

ZN438_HUMAN

Zinc finger protein 438

0.387

BRNP1_HUMAN

BMP/retinoic acid-inducible neural-specific protein 1

0.387

BTC_HUMAN

Probetacellulin

0.387

BSPRY_HUMAN

B box and SPRY domain-containing protein

0.387

CSH2_HUMAN

Chorionic somatomammotropin hormone 2

0.387

PAR2_HUMAN

Proteinase-activated receptor 2

0.387

INHA_HUMAN

Inhibin alpha chain

0.387

SOMA_HUMAN

Somatotropin

0.387

MYP0_HUMAN

Myelin protein P0

0.387

RN214_HUMAN

RING finger protein 214

0.387

ZN217_HUMAN

Zinc finger protein 217

0.387

UIMC1_HUMAN

BRCA1-A complex subunit RAP80

0.387

SE6L1_HUMAN

Seizure 6-like protein

0.387

ARTN_HUMAN

Artemin

0.387

CSH1_HUMAN

Chorionic somatomammotropin hormone 1

0.387

IL2RG_HUMAN

Cytokine receptor common subunit gamma

0.387

CRBA4_HUMAN

Beta-crystallin A4

0.387

CKP2L_HUMAN

Cytoskeleton-associated protein 2-like

0.387

VTM2L_HUMAN

V-set and transmembrane domain-containing protein 2-like protein

0.387

SOM2_HUMAN

Growth hormone variant

0.387

TOR4A_HUMAN

Torsin-4A

0.387

CK2N2_HUMAN

Calcium/calmodulin-dependent protein kinase II inhibitor 2

0.387

TLE5_HUMAN

TLE family member 5

0.397

APOE_HUMAN

Apolipoprotein E

0.397

GPR55_HUMAN

G-protein coupled receptor 55

0.397

PLVAP_HUMAN

Plasmalemma vesicle-associated protein

0.397

TELT_HUMAN

Telethonin

0.397

CCL19_HUMAN

C-C motif chemokine 19

0.397

I13R2_HUMAN

Interleukin-13 receptor subunit alpha-2

0.397

KCP3_HUMAN

Keratinocyte-associated protein 3

0.397

FA83G_HUMAN

Protein FAM83G

0.397

GP135_HUMAN

G-protein coupled receptor 135

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

HPLN4_HUMAN

Hyaluronan and proteoglycan link protein 4

0.350

HPLN1_HUMAN

Hyaluronan and proteoglycan link protein 1

0.368

VTM2L_HUMAN

V-set and transmembrane domain-containing protein 2-like protein

0.390

SOST_HUMAN

Sclerostin

0.397

ASB4_HUMAN

Ankyrin repeat and SOCS box protein 4

0.397

HPLN3_HUMAN

Hyaluronan and proteoglycan link protein 3

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 19 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy