GFRA4_HUMAN 2019

Gene Name GFRA4

Description GDNF family receptor alpha-4

Length 299

9606

Sequence

>sp|Q9GZZ7|GFRA4_HUMAN GDNF family receptor alpha-4
MVRCLGPALLLLLLLGSASSVGGNRCVDAAEACTADARCQRLRSEYVAQCLGRAAQGGCPRARCRRALRRFFARGPPALTHALLFCPCAGPACAERRRQTFVPSCAFSGPGPAPPSCLEPLNFCERSRVCRCARAAAGPWRGWGRGLSPAHRPPAAQASPPGLSGLVHPSAQRPRRLPAGPGRPLPARLRGPRGVPAGTAVTPNYVDNVSARVAPWCDCGASGNRREDCEAFRGLFTRNRCLDGAIQAFASGWPPVLLDQLNPQGDPEHSLLQVSSTGRALERRSLLSILPVLALPALL

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ZCH12_HUMAN

Zinc finger CCHC domain-containing protein 12

0.000

KCNK7_HUMAN

Potassium channel subfamily K member 7

0.354

PRCA1_HUMAN

Protein PROCA1

0.378

ARMX6_HUMAN

Protein ARMCX6

0.378

MRGRG_HUMAN

Mas-related G-protein coupled receptor member G

0.378

ZFP1_HUMAN

Zinc finger protein 1 homolog

0.378

ZN454_HUMAN

Zinc finger protein 454

0.378

LYPD4_HUMAN

Ly6/PLAUR domain-containing protein 4

0.378

RASE_HUMAN

GTPase ERas

0.378

OR2Z1_HUMAN

Olfactory receptor 2Z1

0.378

F170A_HUMAN

Protein FAM170A

0.378

O4A47_HUMAN

Olfactory receptor 4A47

0.378

SIML1_HUMAN

Small integral membrane protein 10-like protein 1

0.378

OR8H2_HUMAN

Olfactory receptor 8H2

0.378

ZN189_HUMAN

Zinc finger protein 189

0.378

DB123_HUMAN

Beta-defensin 123

0.378

MRAP_HUMAN

Melanocortin-2 receptor accessory protein

0.378

MAGIX_HUMAN

PDZ domain-containing protein MAGIX

0.378

CA105_HUMAN

Uncharacterized protein C1orf105

0.378

CASK_HUMAN

Kappa-casein

0.378

O10J5_HUMAN

Olfactory receptor 10J5

0.378

GPR3_HUMAN

G-protein coupled receptor 3

0.378

SPESP_HUMAN

Sperm equatorial segment protein 1

0.378

ZN689_HUMAN

Zinc finger protein 689

0.378

MT3_HUMAN

Metallothionein-3

0.378

F90A1_HUMAN

Protein FAM90A1

0.378

SRTD3_HUMAN

SERTA domain-containing protein 3

0.378

SYNE4_HUMAN

Nesprin-4

0.378

TNF18_HUMAN

Tumor necrosis factor ligand superfamily member 18

0.378

DB119_HUMAN

Beta-defensin 119

0.378

GASP2_HUMAN

G-protein coupled receptor-associated sorting protein 2

0.378

DB110_HUMAN

Beta-defensin 110

0.378

CS057_HUMAN

Uncharacterized protein C19orf57

0.378

F90AP_HUMAN

Putative protein FAM90A26

0.378

TX101_HUMAN

Testis-expressed protein 101

0.378

FWCH2_HUMAN

FLYWCH family member 2

0.378

UTF1_HUMAN

Undifferentiated embryonic cell transcription factor 1

0.378

KR10C_HUMAN

Keratin-associated protein 10-12

0.378

CI131_HUMAN

Uncharacterized protein C9orf131

0.378

ZN182_HUMAN

Zinc finger protein 182

0.378

MZF1_HUMAN

Myeloid zinc finger 1

0.378

BPIA3_HUMAN

BPI fold-containing family A member 3

0.378

CB074_HUMAN

Uncharacterized protein C2orf74

0.378

PVRIG_HUMAN

Transmembrane protein PVRIG

0.378

OOEP_HUMAN

Oocyte-expressed protein homolog

0.378

MOFA1_HUMAN

MORF4 family-associated protein 1

0.378

CASB_HUMAN

Beta-casein

0.378

S31C1_HUMAN

Putative spermatogenesis-associated protein 31C1

0.378

Z354A_HUMAN

Zinc finger protein 354A

0.378

LY65B_HUMAN

Lymphocyte antigen 6 complex locus protein G5b

0.378

TX13D_HUMAN

Testis-expressed protein 13D

0.378

OR8BC_HUMAN

Olfactory receptor 8B12

0.378

OR8B3_HUMAN

Olfactory receptor 8B3

0.378

LY65C_HUMAN

Lymphocyte antigen 6 complex locus protein G5c

0.378

ARMX5_HUMAN

Armadillo repeat-containing X-linked protein 5

0.378

ZN473_HUMAN

Zinc finger protein 473

0.378

S31A3_HUMAN

Spermatogenesis-associated protein 31A3

0.378

CA141_HUMAN

Uncharacterized protein C1orf141

0.378

DB129_HUMAN

Beta-defensin 129

0.378

DB113_HUMAN

Beta-defensin 113

0.378

BEX3_HUMAN

Protein BEX3

0.378

OR7A2_HUMAN

Putative olfactory receptor 7A2

0.378

LAIR1_HUMAN

Leukocyte-associated immunoglobulin-like receptor 1

0.378

CXG3_HUMAN

Gap junction gamma-3 protein

0.378

BEX2_HUMAN

Protein BEX2

0.378

RNAS9_HUMAN

Inactive ribonuclease-like protein 9

0.378

MS4A7_HUMAN

Membrane-spanning 4-domains subfamily A member 7

0.378

MCEM1_HUMAN

Mast cell-expressed membrane protein 1

0.378

HCST_HUMAN

Hematopoietic cell signal transducer

0.378

ZN317_HUMAN

Zinc finger protein 317

0.378

O8G2P_HUMAN

Putative olfactory receptor 8G2

0.378

KR10B_HUMAN

Keratin-associated protein 10-11

0.378

TM88B_HUMAN

Transmembrane protein 88B

0.378

A0A2R8Y4Q1_HUMAN

Olfactory receptor 7E24

0.378

PR23A_HUMAN

Proline-rich protein 23A

0.378

T126B_HUMAN

Complex I assembly factor TMEM126B, mitochondrial

0.378

LCN8_HUMAN

Epididymal-specific lipocalin-8

0.378

CX049_HUMAN

Uncharacterized protein CXorf49

0.378

ZFP37_HUMAN

Zinc finger protein 37 homolog

0.378

Z354C_HUMAN

Zinc finger protein 354C

0.378

TRIMM_HUMAN

Probable E3 ubiquitin-protein ligase TRIML2

0.378

ZN597_HUMAN

Zinc finger protein 597

0.378

ZNF12_HUMAN

Zinc finger protein 12

0.378

T191C_HUMAN

Transmembrane protein 191C

0.378

PRR3_HUMAN

Proline-rich protein 3

0.378

IL2_HUMAN

Interleukin-2

0.378

ZN205_HUMAN

Zinc finger protein 205

0.378

OR8K3_HUMAN

Olfactory receptor 8K3

0.378

SPT33_HUMAN

Spermatogenesis-associated protein 33

0.378

CXL17_HUMAN

C-X-C motif chemokine 17

0.378

IRGQ_HUMAN

Immunity-related GTPase family Q protein

0.378

ZN445_HUMAN

Zinc finger protein 445

0.378

F209B_HUMAN

Protein FAM209B

0.378

SIGL1_HUMAN

SIGLEC family-like protein 1

0.378

Z324A_HUMAN

Zinc finger protein 324A

0.378

ONCM_HUMAN

Oncostatin-M

0.378

ZN691_HUMAN

Zinc finger protein 691

0.378

DB118_HUMAN

Beta-defensin 118

0.378

STP2_HUMAN

Nuclear transition protein 2

0.378

TCL1A_HUMAN

T-cell leukemia/lymphoma protein 1A

0.378

ZFP90_HUMAN

Zinc finger protein 90 homolog

0.378

D105A_HUMAN

Beta-defensin 105

0.378

OR5P2_HUMAN

Olfactory receptor 5P2

0.378

PIP_HUMAN

Prolactin-inducible protein

0.378

BSPH1_HUMAN

Binder of sperm protein homolog 1

0.378

ZN605_HUMAN

Zinc finger protein 605

0.378

KR131_HUMAN

Keratin-associated protein 13-1

0.378

ZN786_HUMAN

Zinc finger protein 786

0.378

DB124_HUMAN

Beta-defensin 124

0.378

CXL16_HUMAN

C-X-C motif chemokine 16

0.378

BPIA2_HUMAN

BPI fold-containing family A member 2

0.378

CL12A_HUMAN

C-type lectin domain family 12 member A

0.378

ABC3F_HUMAN

DNA dC->dU-editing enzyme APOBEC-3F

0.378

PCSK1_HUMAN

ProSAAS

0.378

PR23B_HUMAN

Proline-rich protein 23B

0.378

DB125_HUMAN

Beta-defensin 125

0.378

IL31_HUMAN

Interleukin-31

0.378

ZSC25_HUMAN

Zinc finger and SCAN domain-containing protein 25

0.378

PATE3_HUMAN

Prostate and testis expressed protein 3

0.378

H1FNT_HUMAN

Testis-specific H1 histone

0.378

CK071_HUMAN

Uncharacterized protein C11orf71

0.378

ZN322_HUMAN

Zinc finger protein 322

0.378

TCAL7_HUMAN

Transcription elongation factor A protein-like 7

0.378

CT141_HUMAN

Uncharacterized protein C20orf141

0.378

A0A286YEU6_HUMAN

Uncharacterized protein

0.378

WF10A_HUMAN

WAP four-disulfide core domain protein 10A

0.378

TEX37_HUMAN

Testis-expressed sequence 37 protein

0.378

NP1L5_HUMAN

Nucleosome assembly protein 1-like 5

0.378

CE046_HUMAN

Uncharacterized protein C5orf46

0.378

BEX4_HUMAN

Protein BEX4

0.378

OR8S1_HUMAN

Olfactory receptor 8S1

0.378

NNAT_HUMAN

Neuronatin

0.378

S31A1_HUMAN

Spermatogenesis-associated protein 31A1

0.378

PXT1_HUMAN

Peroxisomal testis-specific protein 1

0.378

IL33_HUMAN

Interleukin-33

0.378

ZKSC4_HUMAN

Zinc finger protein with KRAB and SCAN domains 4

0.378

ZN558_HUMAN

Zinc finger protein 558

0.378

CALY_HUMAN

Neuron-specific vesicular protein calcyon

0.378

ZFP28_HUMAN

Zinc finger protein 28 homolog

0.378

OR8B4_HUMAN

Olfactory receptor 8B4

0.378

CCL23_HUMAN

C-C motif chemokine 23

0.378

A1BG_HUMAN

Alpha-1B-glycoprotein

0.378

BST2_HUMAN

Bone marrow stromal antigen 2

0.378

CC022_HUMAN

Uncharacterized protein C3orf22

0.378

ZNF23_HUMAN

Zinc finger protein 23

0.378

CCL15_HUMAN

C-C motif chemokine 15

0.378

CC187_HUMAN

Coiled-coil domain-containing protein 187

0.378

BHLH9_HUMAN

Protein BHLHb9

0.378

TCAL8_HUMAN

Transcription elongation factor A protein-like 8

0.378

UTER_HUMAN

Uteroglobin

0.378

KRA71_HUMAN

Keratin-associated protein 7-1

0.378

PATE2_HUMAN

Prostate and testis expressed protein 2

0.378

CD320_HUMAN

CD320 antigen

0.378

CE047_HUMAN

Uncharacterized protein C5orf47

0.378

SPEM2_HUMAN

Uncharacterized protein SPEM2

0.378

ARMX4_HUMAN

Armadillo repeat-containing X-linked protein 4

0.378

ZN775_HUMAN

Zinc finger protein 775

0.378

ZSCA4_HUMAN

Zinc finger and SCAN domain-containing protein 4

0.378

KR132_HUMAN

Keratin-associated protein 13-2

0.378

KR105_HUMAN

Keratin-associated protein 10-5

0.378

OR1D2_HUMAN

Olfactory receptor 1D2

0.378

CSF2_HUMAN

Granulocyte-macrophage colony-stimulating factor

0.378

NKG2E_HUMAN

NKG2-E type II integral membrane protein

0.378

TCAL1_HUMAN

Transcription elongation factor A protein-like 1

0.378

PNM8A_HUMAN

Paraneoplastic antigen-like protein 8A

0.378

M4A10_HUMAN

Membrane-spanning 4-domains subfamily A member 10

0.378

TR13C_HUMAN

Tumor necrosis factor receptor superfamily member 13C

0.378

PTMS_HUMAN

Parathymosin

0.378

PR23C_HUMAN

Proline-rich protein 23C

0.378

OR1L8_HUMAN

Olfactory receptor 1L8

0.378

S31A5_HUMAN

Spermatogenesis-associated protein 31A5

0.378

OR4F3_HUMAN

Olfactory receptor 4F3/4F16/4F29

0.378

ZN174_HUMAN

Zinc finger protein 174

0.378

O2AK2_HUMAN

Olfactory receptor 2AK2

0.378

AARD_HUMAN

Alanine and arginine-rich domain-containing protein

0.378

OR7AA_HUMAN

Olfactory receptor 7A10

0.378

SHRM1_HUMAN

Protein Shroom1

0.378

ZN444_HUMAN

Zinc finger protein 444

0.378

CI153_HUMAN

Uncharacterized protein C9orf153

0.378

O5AN1_HUMAN

Olfactory receptor 5AN1

0.378

CST9P_HUMAN

Putative cystatin-9-like protein CST9LP1

0.378

WFDC9_HUMAN

Protein WFDC9

0.378

CST9L_HUMAN

Cystatin-9-like

0.378

T191B_HUMAN

Transmembrane protein 191B

0.378

ZN394_HUMAN

Zinc finger protein 394

0.378

CKLF2_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 2

0.378

PEG3_HUMAN

Paternally-expressed gene 3 protein

0.378

ZFP57_HUMAN

Zinc finger protein 57 homolog

0.378

MYMX_HUMAN

Protein myomixer

0.378

S31C2_HUMAN

Putative spermatogenesis-associated protein 31C2

0.378

ABC3D_HUMAN

DNA dC->dU-editing enzyme APOBEC-3D

0.378

IL13_HUMAN

Interleukin-13

0.378

RNAS6_HUMAN

Ribonuclease K6

0.378

CYLC1_HUMAN

Cylicin-1

0.378

S31A6_HUMAN

Spermatogenesis-associated protein 31A6

0.378

OR8H3_HUMAN

Olfactory receptor 8H3

0.378

TKN4_HUMAN

Tachykinin-4

0.378

WFD13_HUMAN

WAP four-disulfide core domain protein 13

0.378

ZN382_HUMAN

Zinc finger protein 382

0.378

RBAK_HUMAN

RB-associated KRAB zinc finger protein

0.378

HRCT1_HUMAN

Histidine-rich carboxyl terminus protein 1

0.378

DB136_HUMAN

Beta-defensin 136

0.378

F209A_HUMAN

Protein FAM209A

0.378

CI050_HUMAN

Uncharacterized protein C9orf50

0.378

Z324B_HUMAN

Zinc finger protein 324B

0.378

OR8B2_HUMAN

Olfactory receptor 8B2

0.378

KR271_HUMAN

Keratin-associated protein 27-1

0.378

D103A_HUMAN

Beta-defensin 103

0.378

KHD3L_HUMAN

KHDC3-like protein

0.378

ZN667_HUMAN

Zinc finger protein 667

0.378

O10Z1_HUMAN

Olfactory receptor 10Z1

0.378

F205C_HUMAN

Protein FAM205C

0.378

CV046_HUMAN

Uncharacterized protein C22orf46

0.378

TEX28_HUMAN

Testis-specific protein TEX28

0.378

LST1_HUMAN

Leukocyte-specific transcript 1 protein

0.378

ZNF7_HUMAN

Zinc finger protein 7

0.378

WF10B_HUMAN

Protein WFDC10B

0.378

ZN275_HUMAN

Zinc finger protein 275

0.378

O10AD_HUMAN

Olfactory receptor 10AD1

0.378

TCAL9_HUMAN

Transcription elongation factor A protein-like 9

0.378

ZKSC3_HUMAN

Zinc finger protein with KRAB and SCAN domains 3

0.378

GCSAM_HUMAN

Germinal center-associated signaling and motility protein

0.378

RNF39_HUMAN

RING finger protein 39

0.378

CP092_HUMAN

Uncharacterized protein C16orf92

0.378

DB116_HUMAN

Beta-defensin 116

0.378

CD177_HUMAN

CD177 antigen

0.378

CX066_HUMAN

Uncharacterized protein CXorf66

0.378

PRAP1_HUMAN

Proline-rich acidic protein 1

0.378

ZN329_HUMAN

Zinc finger protein 329

0.378

PYY_HUMAN

Peptide YY

0.378

CP090_HUMAN

Uncharacterized protein C16orf90

0.378

O7E24_HUMAN

Olfactory receptor 7E24

0.378

O4F21_HUMAN

Olfactory receptor 4F21

0.378

HSPB9_HUMAN

Heat shock protein beta-9

0.378

CABS1_HUMAN

Calcium-binding and spermatid-specific protein 1

0.378

NCTR1_HUMAN

Natural cytotoxicity triggering receptor 1

0.378

INSL6_HUMAN

Insulin-like peptide INSL6

0.378

CF141_HUMAN

Uncharacterized protein C6orf141

0.378

DKKL1_HUMAN

Dickkopf-like protein 1

0.378

ZN575_HUMAN

Zinc finger protein 575

0.378

TRI34_HUMAN

Tripartite motif-containing protein 34

0.378

OR1A1_HUMAN

Olfactory receptor 1A1

0.378

ZN239_HUMAN

Zinc finger protein 239

0.378

ERIC4_HUMAN

Glutamate-rich protein 4

0.378

OR7G1_HUMAN

Olfactory receptor 7G1

0.378

OR2D3_HUMAN

Olfactory receptor 2D3

0.378

ZNF48_HUMAN

Zinc finger protein 48

0.378

ZSC26_HUMAN

Zinc finger and SCAN domain-containing protein 26

0.378

A0A1B0GWI6_HUMAN

Uncharacterized protein

0.378

S31A7_HUMAN

Spermatogenesis-associated protein 31A7

0.378

PLAC1_HUMAN

Placenta-specific protein 1

0.378

S31D3_HUMAN

Spermatogenesis-associated protein 31D3

0.378

ZFP3_HUMAN

Zinc finger protein 3 homolog

0.378

ODFP4_HUMAN

Outer dense fiber protein 4

0.378

PRS46_HUMAN

Putative serine protease 46

0.378

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

FCERB_HUMAN

High affinity immunoglobulin epsilon receptor subunit beta

0.385

MAGIX_HUMAN

PDZ domain-containing protein MAGIX

0.392

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 48 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy