P63_HUMAN 2019

Gene Name P63

Description Tumor protein 63

Length 680

9606

Sequence

>sp|Q9H3D4|P63_HUMAN Tumor protein 63
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

P73_HUMAN

Tumor protein p73

0.147

P53_HUMAN

Cellular tumor antigen p53

0.298

INSR_HUMAN

Insulin receptor

0.319

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.343

ARFP1_HUMAN

Arfaptin-1

0.343

TP8L3_HUMAN

Tumor necrosis factor alpha-induced protein 8-like protein 3

0.350

HOME3_HUMAN

Homer protein homolog 3

0.354

RAPH1_HUMAN

Ras-associated and pleckstrin homology domains-containing protein 1

0.367

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.370

ARRB2_HUMAN

Beta-arrestin-2

0.370

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.374

CREL2_HUMAN

Cysteine-rich with EGF-like domain protein 2

0.374

AP2A_HUMAN

Transcription factor AP-2-alpha

0.378

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.378

FOXO3_HUMAN

Forkhead box protein O3

0.378

TM129_HUMAN

E3 ubiquitin-protein ligase TM129

0.378

FA8A1_HUMAN

Protein FAM8A1

0.378

GO45_HUMAN

Golgin-45

0.382

IP3KA_HUMAN

Inositol-trisphosphate 3-kinase A

0.389

ARRB1_HUMAN

Beta-arrestin-1

0.389

SZRD1_HUMAN

SUZ domain-containing protein 1

0.390

STIM1_HUMAN

Stromal interaction molecule 1

0.392

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.392

STIM2_HUMAN

Stromal interaction molecule 2

0.392

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.392

MOES_HUMAN

Moesin

0.396

MAPK2_HUMAN

MAP kinase-activated protein kinase 2

0.396

FGFR2_HUMAN

Fibroblast growth factor receptor 2

0.396

RHG10_HUMAN

Rho GTPase-activating protein 10

0.396

RUNX2_HUMAN

Runt-related transcription factor 2

0.396

NHRF1_HUMAN

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

0.396

FGFR1_HUMAN

Fibroblast growth factor receptor 1

0.396

ARFP2_HUMAN

Arfaptin-2

0.396

BAF_HUMAN

Barrier-to-autointegration factor

0.396

EPHA4_HUMAN

Ephrin type-A receptor 4

0.400

IGF1R_HUMAN

Insulin-like growth factor 1 receptor

0.400

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.400

HOME1_HUMAN

Homer protein homolog 1

0.400

DLG1_HUMAN

Disks large homolog 1

0.400

GIT2_HUMAN

ARF GTPase-activating protein GIT2

0.400

HLF_HUMAN

Hepatic leukemia factor

0.400

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.400

RHG42_HUMAN

Rho GTPase-activating protein 42

0.400

SNTB1_HUMAN

Beta-1-syntrophin

0.400

ORAI2_HUMAN

Protein orai-2

0.400

MACOI_HUMAN

Macoilin

0.400

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

P73_HUMAN

Tumor protein p73

0.209

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.330

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.335

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.339

SCMH1_HUMAN

Polycomb protein SCMH1

0.355

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.359

GO45_HUMAN

Golgin-45

0.365

LLR1_HUMAN

Leucine-rich repeat protein 1

0.370

ARFP1_HUMAN

Arfaptin-1

0.376

GIT2_HUMAN

ARF GTPase-activating protein GIT2

0.379

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.381

HOME2_HUMAN

Homer protein homolog 2

0.382

41_HUMAN

Protein 4.1

0.382

HINFP_HUMAN

Histone H4 transcription factor

0.383

HOME1_HUMAN

Homer protein homolog 1

0.383

RT22_HUMAN

28S ribosomal protein S22, mitochondrial

0.383

TP8L3_HUMAN

Tumor necrosis factor alpha-induced protein 8-like protein 3

0.384

P53_HUMAN

Cellular tumor antigen p53

0.384

TEF_HUMAN

Thyrotroph embryonic factor

0.384

TBK1_HUMAN

Serine/threonine-protein kinase TBK1

0.385

MED24_HUMAN

Mediator of RNA polymerase II transcription subunit 24

0.387

HD_HUMAN

Huntingtin

0.387

PCX1_HUMAN

Pecanex-like protein 1

0.387

APBP2_HUMAN

Amyloid protein-binding protein 2

0.388

PDC10_HUMAN

Programmed cell death protein 10

0.388

ETS1_HUMAN

Protein C-ets-1

0.389

TRIO_HUMAN

Triple functional domain protein

0.389

HLF_HUMAN

Hepatic leukemia factor

0.390

TM39B_HUMAN

Transmembrane protein 39B

0.390

BAKOR_HUMAN

Beclin 1-associated autophagy-related key regulator

0.391

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.391

FBX28_HUMAN

F-box only protein 28

0.392

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.392

AHR_HUMAN

Aryl hydrocarbon receptor

0.392

WAC_HUMAN

WW domain-containing adapter protein with coiled-coil

0.394

PDXD1_HUMAN

Pyridoxal-dependent decarboxylase domain-containing protein 1

0.394

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.394

MIGA2_HUMAN

Mitoguardin 2

0.394

ARFP2_HUMAN

Arfaptin-2

0.395

DGC6L_HUMAN

Protein DGCR6L

0.395

DGCR6_HUMAN

Protein DGCR6

0.395

TM39A_HUMAN

Transmembrane protein 39A

0.396

STK10_HUMAN

Serine/threonine-protein kinase 10

0.396

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.396

SH2B2_HUMAN

SH2B adapter protein 2

0.396

EHBP1_HUMAN

EH domain-binding protein 1

0.397

BCAR1_HUMAN

Breast cancer anti-estrogen resistance protein 1

0.397

JKAMP_HUMAN

JNK1/MAPK8-associated membrane protein

0.397

PRIC2_HUMAN

Prickle-like protein 2

0.397

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.397

ITB1_HUMAN

Integrin beta-1

0.397

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.397

TSN7_HUMAN

Tetraspanin-7

0.397

AXIN1_HUMAN

Axin-1

0.398

UBN2_HUMAN

Ubinuclein-2

0.399

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.399

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.399

PAR3L_HUMAN

Partitioning defective 3 homolog B

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 45 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy