COE2_HUMAN 2019

Gene Name COE2

Description Transcription factor COE2

Length 575

9606

Sequence

>sp|Q9HAK2|COE2_HUMAN Transcription factor COE2
MFGIQDTLGRGPTLKEKSLGAEMDSVRSWVRNVGVVDANVAAQSGVALSRAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVENDKEQGNEKTNNGTHYKLQLLYSNGVRTEQDLYVRLIDSVTKQPIAYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGAMVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLAKEMLLKRAADLVEALYGTPHNNQDIILKRAADIAEALYSVPRNPSQLPALSSSPAHSGMMGINSYGSQLGVSISESTQGNNQGYIRNTSSISPRGYSSSSTPQQSNYSTSSNSMNGYSNVPMANLGVPGSPGFLNGSPTGSPYGIMSSSPTVGSSSTSSILPFSSSVFPAVKQKSAFAPVIRPQGSPSPACSSGNGNGFRAMTGLVVPPM

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

FERM2_HUMAN

Fermitin family homolog 2

0.313

FERM1_HUMAN

Fermitin family homolog 1

0.313

RUNX2_HUMAN

Runt-related transcription factor 2

0.313

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.313

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.316

RUNX1_HUMAN

Runt-related transcription factor 1

0.319

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.340

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.340

WLS_HUMAN

Protein wntless homolog

0.343

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.343

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.343

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.343

BMP2_HUMAN

Bone morphogenetic protein 2

0.343

CTNA1_HUMAN

Catenin alpha-1

0.343

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.343

TGFR1_HUMAN

TGF-beta receptor type-1

0.343

COE1_HUMAN

Transcription factor COE1

0.346

EGR1_HUMAN

Early growth response protein 1

0.346

NFIB_HUMAN

Nuclear factor 1 B-type

0.346

JPH3_HUMAN

Junctophilin-3

0.346

FA8A1_HUMAN

Protein FAM8A1

0.346

NFIA_HUMAN

Nuclear factor 1 A-type

0.346

TM129_HUMAN

E3 ubiquitin-protein ligase TM129

0.346

FOXO3_HUMAN

Forkhead box protein O3

0.346

TFE2_HUMAN

Transcription factor E2-alpha

0.346

AP2A_HUMAN

Transcription factor AP-2-alpha

0.346

CPEB2_HUMAN

Cytoplasmic polyadenylation element-binding protein 2

0.346

ACV1C_HUMAN

Activin receptor type-1C

0.346

LIPA1_HUMAN

Liprin-alpha-1

0.346

CAPS2_HUMAN

Calcium-dependent secretion activator 2

0.350

ITB1_HUMAN

Integrin beta-1

0.360

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.363

ARFP1_HUMAN

Arfaptin-1

0.363

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.363

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.367

TLE4_HUMAN

Transducin-like enhancer protein 4

0.367

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.367

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.367

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.367

TLE1_HUMAN

Transducin-like enhancer protein 1

0.367

BAF_HUMAN

Barrier-to-autointegration factor

0.367

SYT1_HUMAN

Synaptotagmin-1

0.367

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.370

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.370

CAPS1_HUMAN

Calcium-dependent secretion activator 1

0.370

ROR1_HUMAN

Inactive tyrosine-protein kinase transmembrane receptor ROR1

0.370

CPEB4_HUMAN

Cytoplasmic polyadenylation element-binding protein 4

0.370

BMP7_HUMAN

Bone morphogenetic protein 7

0.370

JPH1_HUMAN

Junctophilin-1

0.370

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.370

NET1_HUMAN

Netrin-1

0.370

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.370

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.370

HTF4_HUMAN

Transcription factor 12

0.370

BMP4_HUMAN

Bone morphogenetic protein 4

0.370

MACOI_HUMAN

Macoilin

0.370

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.370

GIT2_HUMAN

ARF GTPase-activating protein GIT2

0.370

RUND1_HUMAN

RUN domain-containing protein 1

0.370

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.370

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.370

PROM1_HUMAN

Prominin-1

0.370

WNT5A_HUMAN

Protein Wnt-5a

0.370

HLF_HUMAN

Hepatic leukemia factor

0.370

AT1B4_HUMAN

Protein ATP1B4

0.370

PO4F3_HUMAN

POU domain, class 4, transcription factor 3

0.374

LMNB2_HUMAN

Lamin-B2

0.374

COE3_HUMAN

Transcription factor COE3

0.374

RT24_HUMAN

28S ribosomal protein S24, mitochondrial

0.374

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.374

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.374

NFIC_HUMAN

Nuclear factor 1 C-type

0.374

PHKG1_HUMAN

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

0.374

TRIO_HUMAN

Triple functional domain protein

0.374

C43BP_HUMAN

Collagen type IV alpha-3-binding protein

0.381

TFAP4_HUMAN

Transcription factor AP-4

0.385

EGR3_HUMAN

Early growth response protein 3

0.389

ITB3_HUMAN

Integrin beta-3

0.389

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.389

MTA1_HUMAN

Metastasis-associated protein MTA1

0.389

ARRB2_HUMAN

Beta-arrestin-2

0.389

SNX6_HUMAN

Sorting nexin-6

0.389

PDC10_HUMAN

Programmed cell death protein 10

0.389

MIGA2_HUMAN

Mitoguardin 2

0.392

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.392

TF7L2_HUMAN

Transcription factor 7-like 2

0.392

GFI1_HUMAN

Zinc finger protein Gfi-1

0.392

NRBP_HUMAN

Nuclear receptor-binding protein

0.392

INSR_HUMAN

Insulin receptor

0.392

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.392

IRX4_HUMAN

Iroquois-class homeodomain protein IRX-4

0.392

DVL2_HUMAN

Segment polarity protein dishevelled homolog DVL-2

0.392

E41L5_HUMAN

Band 4.1-like protein 5

0.396

HINFP_HUMAN

Histone H4 transcription factor

0.396

FOXO1_HUMAN

Forkhead box protein O1

0.396

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.396

FABP7_HUMAN

Fatty acid-binding protein, brain

0.396

ZO1_HUMAN

Tight junction protein ZO-1

0.396

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.396

AP2B_HUMAN

Transcription factor AP-2-beta

0.396

RAB3A_HUMAN

Ras-related protein Rab-3A

0.396

PTPRN_HUMAN

Receptor-type tyrosine-protein phosphatase-like N

0.396

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.396

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.396

FEM1C_HUMAN

Protein fem-1 homolog C

0.396

ITF2_HUMAN

Transcription factor 4

0.396

TEF_HUMAN

Thyrotroph embryonic factor

0.396

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.396

RIPL1_HUMAN

RILP-like protein 1

0.396

AVR2A_HUMAN

Activin receptor type-2A

0.396

VANG1_HUMAN

Vang-like protein 1

0.396

STON1_HUMAN

Stonin-1

0.396

PAR6G_HUMAN

Partitioning defective 6 homolog gamma

0.396

BMP5_HUMAN

Bone morphogenetic protein 5

0.396

TSN5_HUMAN

Tetraspanin-5

0.396

RN146_HUMAN

E3 ubiquitin-protein ligase RNF146

0.396

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.396

FZD2_HUMAN

Frizzled-2

0.400

VANG2_HUMAN

Vang-like protein 2

0.400

GFI1B_HUMAN

Zinc finger protein Gfi-1b

0.400

PAR6A_HUMAN

Partitioning defective 6 homolog alpha

0.400

UNC79_HUMAN

Protein unc-79 homolog

0.400

AHR_HUMAN

Aryl hydrocarbon receptor

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

COE1_HUMAN

Transcription factor COE1

0.323

COE3_HUMAN

Transcription factor COE3

0.376

ITB1_HUMAN

Integrin beta-1

0.388

FERM1_HUMAN

Fermitin family homolog 1

0.391

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 200 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy