F1142_HUMAN 2019

Gene Name F1142

Description Protein FAM114A2

Length 505

9606

Sequence

>sp|Q9NRY5|F1142_HUMAN Protein FAM114A2
MSDKDDIETPLLTEAAPILEDGNCEPAKNSESVDQGAKPESKSEPVVSTRKRPETKPSSDLETSKVLPIQDNVSKDVPQTRWGYWGSWGKSILSSASATVATVGQGISNVIEKAETSLGIPGPSEISTEVKYVAGETNAKENENSSPVAGAFGVFSTISTAVQSTGKSVISGGLDALEFIGKKTMDVIAEGDPGFKRTKGLMNRNATLSQVLREAKEKEEIRTSNEVTVETDKKTHYGLLFDEFQGLSHLEALEMLSQESEIKVKSILNSLSGEELETLKVELEQLKETFSLAEFCEEEEEEKKGDEDFTKDITELFSQLHVSSKPEKLARARNTAHEWIRKSLTKPLAENEEGEKQSEAENTEQVNKNSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGRKQEVTAIERSQTLSQMTIVLCKELSSLSKEFTTCLTTAGVKEMADVLNPLITAVFLEASNSASYIQDAFQLLLPVLEISLIENKIESHRHELQGQKPLLEH

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NXP20_HUMAN

Protein NOXP20

0.156

AXIN1_HUMAN

Axin-1

0.302

CDK14_HUMAN

Cyclin-dependent kinase 14

0.309

TSN7_HUMAN

Tetraspanin-7

0.309

GO45_HUMAN

Golgin-45

0.333

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.337

AXIN2_HUMAN

Axin-2

0.337

ZN704_HUMAN

Zinc finger protein 704

0.337

LMBL3_HUMAN

Lethal(3)malignant brain tumor-like protein 3

0.341

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.341

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.341

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.341

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.341

CYTSA_HUMAN

Cytospin-A

0.341

EGFLA_HUMAN

Pikachurin

0.345

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.345

NEUL2_HUMAN

Neuralized-like protein 2

0.345

TM242_HUMAN

Transmembrane protein 242

0.345

WNT1_HUMAN

Proto-oncogene Wnt-1

0.345

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.345

TP8L3_HUMAN

Tumor necrosis factor alpha-induced protein 8-like protein 3

0.357

HOME1_HUMAN

Homer protein homolog 1

0.357

MACOI_HUMAN

Macoilin

0.357

SKI_HUMAN

Ski oncogene

0.361

CASP7_HUMAN

Caspase-7

0.361

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.361

TBC30_HUMAN

TBC1 domain family member 30

0.361

41_HUMAN

Protein 4.1

0.365

PHC2_HUMAN

Polyhomeotic-like protein 2

0.365

KI26B_HUMAN

Kinesin-like protein KIF26B

0.369

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.369

NRF1_HUMAN

Nuclear respiratory factor 1

0.369

CD151_HUMAN

CD151 antigen

0.369

CRERF_HUMAN

CREB3 regulatory factor

0.369

MEIOB_HUMAN

Meiosis-specific with OB domain-containing protein

0.374

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.374

CC28B_HUMAN

Coiled-coil domain-containing protein 28B

0.374

CYTSB_HUMAN

Cytospin-B

0.374

PTN21_HUMAN

Tyrosine-protein phosphatase non-receptor type 21

0.374

RHGBA_HUMAN

Rho GTPase-activating protein 11A

0.378

DAXX_HUMAN

Death domain-associated protein 6

0.378

NKX32_HUMAN

Homeobox protein Nkx-3.2

0.378

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.378

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.382

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.382

MMS22_HUMAN

Protein MMS22-like

0.383

OAF_HUMAN

Out at first protein homolog

0.383

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.383

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.386

STON1_HUMAN

Stonin-1

0.386

P73_HUMAN

Tumor protein p73

0.386

NDUBA_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

0.390

ZN609_HUMAN

Zinc finger protein 609

0.390

DAG1_HUMAN

Dystroglycan

0.390

MCF2L_HUMAN

Guanine nucleotide exchange factor DBS

0.394

E41L2_HUMAN

Band 4.1-like protein 2

0.394

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.394

LIN37_HUMAN

Protein lin-37 homolog

0.399

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.399

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.399

OTOP1_HUMAN

Proton channel OTOP1

0.399

LHX5_HUMAN

LIM/homeobox protein Lhx5

0.399

MOSMO_HUMAN

Modulator of smoothened protein

0.399

CC85A_HUMAN

Coiled-coil domain-containing protein 85A

0.399

ZCHC2_HUMAN

Zinc finger CCHC domain-containing protein 2

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NXP20_HUMAN

Protein NOXP20

0.214

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.354

TP8L3_HUMAN

Tumor necrosis factor alpha-induced protein 8-like protein 3

0.354

TSN7_HUMAN

Tetraspanin-7

0.369

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.376

CASL_HUMAN

Enhancer of filamentation 1

0.381

NRF1_HUMAN

Nuclear respiratory factor 1

0.384

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.385

APBP2_HUMAN

Amyloid protein-binding protein 2

0.385

GO45_HUMAN

Golgin-45

0.388

ZN330_HUMAN

Zinc finger protein 330

0.389

ANKF1_HUMAN

Ankyrin repeat and fibronectin type-III domain-containing protein 1

0.389

TRIB2_HUMAN

Tribbles homolog 2

0.392

LLR1_HUMAN

Leucine-rich repeat protein 1

0.392

GATD1_HUMAN

GATA zinc finger domain-containing protein 1

0.394

HD_HUMAN

Huntingtin

0.396

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.399

K319L_HUMAN

Dyslexia-associated protein KIAA0319-like protein

0.399

HEY1_HUMAN

Hairy/enhancer-of-split related with YRPW motif protein 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 41 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy