SEM3G_HUMAN 2019

Gene Name SEM3G

Description Semaphorin-3G

Length 782

9606

Sequence

>sp|Q9NS98|SEM3G_HUMAN Semaphorin-3G
MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVIVASQLDNLFPPEPKPEEPPARGGLASTPPKAWYKDILQLIGFANLPRVDEYCERVWCRGTTECSGCFRSRSRGKQARGKSWAGLELGKKMKSRVHAEHNRTPREVEAT

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

I20RB_HUMAN

Interleukin-20 receptor subunit beta

0.324

FA83F_HUMAN

Protein FAM83F

0.324

B2MG_HUMAN

Beta-2-microglobulin

0.324

CF089_HUMAN

Bombesin receptor-activated protein C6orf89

0.324

GP119_HUMAN

Glucose-dependent insulinotropic receptor

0.324

TAFA2_HUMAN

Chemokine-like protein TAFA-2

0.324

SEM4D_HUMAN

Semaphorin-4D

0.369

SEM3C_HUMAN

Semaphorin-3C

0.369

BEND7_HUMAN

BEN domain-containing protein 7

0.378

TM206_HUMAN

Transmembrane protein 206

0.378

SEM7A_HUMAN

Semaphorin-7A

0.387

TR150_HUMAN

Thyroid hormone receptor-associated protein 3

0.387

CIART_HUMAN

Circadian-associated transcriptional repressor

0.387

GALA_HUMAN

Galanin peptides

0.387

LRTM1_HUMAN

Leucine-rich repeat and transmembrane domain-containing protein 1

0.387

TMM71_HUMAN

Transmembrane protein 71

0.387

HBEGF_HUMAN

Proheparin-binding EGF-like growth factor

0.387

SCF_HUMAN

Kit ligand

0.387

TCIM_HUMAN

Transcriptional and immune response regulator

0.387

F171B_HUMAN

Protein FAM171B

0.387

CAD17_HUMAN

Cadherin-17

0.387

LUZP1_HUMAN

Leucine zipper protein 1

0.387

MCR_HUMAN

Mineralocorticoid receptor

0.387

SYNCI_HUMAN

Syncoilin

0.387

IN35_HUMAN

Interferon-induced 35 kDa protein

0.387

POF1B_HUMAN

Protein POF1B

0.387

CD048_HUMAN

Neuropeptide-like protein C4orf48

0.387

SCEL_HUMAN

Sciellin

0.387

IAPP_HUMAN

Islet amyloid polypeptide

0.387

SHSA6_HUMAN

Protein shisa-6

0.387

IGLL5_HUMAN

Immunoglobulin lambda-like polypeptide 5

0.387

RELL1_HUMAN

RELT-like protein 1

0.387

CLUL1_HUMAN

Clusterin-like protein 1

0.387

S22AN_HUMAN

Solute carrier family 22 member 23

0.387

XKR8_HUMAN

XK-related protein 8

0.387

F163A_HUMAN

Protein FAM163A

0.387

F131A_HUMAN

Protein FAM131A

0.387

LYRIC_HUMAN

Protein LYRIC

0.387

SUSD5_HUMAN

Sushi domain-containing protein 5

0.387

F180A_HUMAN

Protein FAM180A

0.387

NRN1_HUMAN

Neuritin

0.387

TAFA4_HUMAN

Chemokine-like protein TAFA-4

0.387

TECTB_HUMAN

Beta-tectorin

0.387

AGR2_HUMAN

Anterior gradient protein 2 homolog

0.387

TKN1_HUMAN

Protachykinin-1

0.387

UCN3_HUMAN

Urocortin-3

0.387

BRID5_HUMAN

BRICHOS domain-containing protein 5

0.387

TSHB_HUMAN

Thyrotropin subunit beta

0.397

SNPC2_HUMAN

snRNA-activating protein complex subunit 2

0.397

ANF_HUMAN

Natriuretic peptides A

0.397

IL7RA_HUMAN

Interleukin-7 receptor subunit alpha

0.397

ALPK2_HUMAN

Alpha-protein kinase 2

0.397

MDFI2_HUMAN

MyoD family inhibitor domain-containing protein 2

0.397

TAFA1_HUMAN

Chemokine-like protein TAFA-1

0.397

HBA_HUMAN

Hemoglobin subunit alpha

0.397

IPKG_HUMAN

cAMP-dependent protein kinase inhibitor gamma

0.397

ANGI_HUMAN

Angiogenin

0.397

OXGR1_HUMAN

2-oxoglutarate receptor 1

0.397

PODXL_HUMAN

Podocalyxin

0.397

CABP8_HUMAN

Calcium-binding protein 8

0.397

CCL20_HUMAN

C-C motif chemokine 20

0.397

GUC2A_HUMAN

Guanylin

0.397

NEUT_HUMAN

Neurotensin/neuromedin N

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SEM4G_HUMAN

Semaphorin-4G

0.350

SYNCI_HUMAN

Syncoilin

0.357

IN35_HUMAN

Interferon-induced 35 kDa protein

0.357

TSN1_HUMAN

Tetraspanin-1

0.370

F168A_HUMAN

Protein FAM168A

0.370

F131A_HUMAN

Protein FAM131A

0.370

NRN1_HUMAN

Neuritin

0.372

GUC2A_HUMAN

Guanylin

0.376

FMOD_HUMAN

Fibromodulin

0.382

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.382

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.382

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.382

LYRIC_HUMAN

Protein LYRIC

0.382

CCR7_HUMAN

C-C chemokine receptor type 7

0.382

CLD11_HUMAN

Claudin-11

0.382

CAD17_HUMAN

Cadherin-17

0.382

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.382

ZN335_HUMAN

Zinc finger protein 335

0.382

ANGT_HUMAN

Angiotensinogen

0.382

CXD2_HUMAN

Gap junction delta-2 protein

0.382

SMS_HUMAN

Somatostatin

0.382

LUZP1_HUMAN

Leucine zipper protein 1

0.382

DSG2_HUMAN

Desmoglein-2

0.384

SEM7A_HUMAN

Semaphorin-7A

0.384

ESM1_HUMAN

Endothelial cell-specific molecule 1

0.384

PDYN_HUMAN

Proenkephalin-B

0.386

SCN4B_HUMAN

Sodium channel subunit beta-4

0.386

VTM2A_HUMAN

V-set and transmembrane domain-containing protein 2A

0.386

INKA1_HUMAN

PAK4-inhibitor INKA1

0.388

AGRP_HUMAN

Agouti-related protein

0.388

CO039_HUMAN

Uncharacterized protein C15orf39

0.390

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.393

OCLN_HUMAN

Occludin

0.393

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.393

MYZAP_HUMAN

Myocardial zonula adherens protein

0.393

ZN131_HUMAN

Zinc finger protein 131

0.393

SYBU_HUMAN

Syntabulin

0.393

EPYC_HUMAN

Epiphycan

0.393

NEXMI_HUMAN

Neurite extension and migration factor

0.393

ZN644_HUMAN

Zinc finger protein 644

0.393

PDGFC_HUMAN

Platelet-derived growth factor C

0.393

AGRF5_HUMAN

Adhesion G protein-coupled receptor F5

0.393

NPY_HUMAN

Pro-neuropeptide Y

0.393

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.393

MERB1_HUMAN

bMERB domain-containing protein 1

0.393

LEG1_HUMAN

Galectin-1

0.393

PRL_HUMAN

Prolactin

0.393

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.393

GHR_HUMAN

Growth hormone receptor

0.393

PENK_HUMAN

Proenkephalin-A

0.393

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.393

TR150_HUMAN

Thyroid hormone receptor-associated protein 3

0.395

AGR2_HUMAN

Anterior gradient protein 2 homolog

0.395

CAVN2_HUMAN

Caveolae-associated protein 2

0.395

GDF9_HUMAN

Growth/differentiation factor 9

0.395

PEPL_HUMAN

Periplakin

0.395

HBEGF_HUMAN

Proheparin-binding EGF-like growth factor

0.395

F222B_HUMAN

Protein FAM222B

0.395

SARG_HUMAN

Specifically androgen-regulated gene protein

0.395

MAL_HUMAN

Myelin and lymphocyte protein

0.395

CMGA_HUMAN

Chromogranin-A

0.395

SCF_HUMAN

Kit ligand

0.395

TM182_HUMAN

Transmembrane protein 182

0.395

GPC5C_HUMAN

G-protein coupled receptor family C group 5 member C

0.395

MIME_HUMAN

Mimecan

0.395

SLIK1_HUMAN

SLIT and NTRK-like protein 1

0.395

ERRFI_HUMAN

ERBB receptor feedback inhibitor 1

0.395

R7BP_HUMAN

Regulator of G-protein signaling 7-binding protein

0.395

DLK2_HUMAN

Protein delta homolog 2

0.395

MRAP2_HUMAN

Melanocortin-2 receptor accessory protein 2

0.395

ZBT20_HUMAN

Zinc finger and BTB domain-containing protein 20

0.395

NUFP2_HUMAN

Nuclear fragile X mental retardation-interacting protein 2

0.395

ZN148_HUMAN

Zinc finger protein 148

0.395

ESAM_HUMAN

Endothelial cell-selective adhesion molecule

0.395

PRELP_HUMAN

Prolargin

0.395

F180A_HUMAN

Protein FAM180A

0.395

TNMD_HUMAN

Tenomodulin

0.395

ZN513_HUMAN

Zinc finger protein 513

0.397

K1522_HUMAN

Uncharacterized protein KIAA1522

0.397

SUSD3_HUMAN

Sushi domain-containing protein 3

0.397

POF1B_HUMAN

Protein POF1B

0.397

FGF19_HUMAN

Fibroblast growth factor 19

0.397

CMYA5_HUMAN

Cardiomyopathy-associated protein 5

0.397

CHP3_HUMAN

Calcineurin B homologous protein 3

0.397

F171B_HUMAN

Protein FAM171B

0.397

TRADD_HUMAN

Tumor necrosis factor receptor type 1-associated DEATH domain protein

0.397

HBA_HUMAN

Hemoglobin subunit alpha

0.399

NEUT_HUMAN

Neurotensin/neuromedin N

0.399

IL2RG_HUMAN

Cytokine receptor common subunit gamma

0.399

CF089_HUMAN

Bombesin receptor-activated protein C6orf89

0.399

BMF_HUMAN

Bcl-2-modifying factor

0.399

IC1_HUMAN

Plasma protease C1 inhibitor

0.399

SEM4B_HUMAN

Semaphorin-4B

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 18 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy