DMAC2_HUMAN 2019

Gene Name DMAC2

Description Distal membrane-arm assembly complex protein 2

Length 257

9606

Sequence

>sp|Q9NW81|DMAC2_HUMAN Distal membrane-arm assembly complex protein 2
MAAPWASLRLVAPMWNGRIRGIHRLGAAVAPEGNQKKKRTILQFLTNYFYDVEALRDYLLQREMYKVHEKNRSYTWLEKQHGPYGAGAFFILKQGGAVKFRDKEWIRPDKYGHFSQEFWNFCEVPVEAVDAGDCDINYEGLDNLLRLKELQSLSLQRCCHVDDWCLSRLYPLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLPNCEVVGVDWAEGLKSGPEEQPRDTASPVPA

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ZEB1_HUMAN

Zinc finger E-box-binding homeobox 1

0.302

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.305

NR2C2_HUMAN

Nuclear receptor subfamily 2 group C member 2

0.333

CSTN1_HUMAN

Calsyntenin-1

0.333

CASC3_HUMAN

Protein CASC3

0.337

DIRA2_HUMAN

GTP-binding protein Di-Ras2

0.337

BAP18_HUMAN

Chromatin complexes subunit BAP18

0.337

BC11A_HUMAN

B-cell lymphoma/leukemia 11A

0.337

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.337

ZEB2_HUMAN

Zinc finger E-box-binding homeobox 2

0.337

NFIL3_HUMAN

Nuclear factor interleukin-3-regulated protein

0.337

SYDE2_HUMAN

Rho GTPase-activating protein SYDE2

0.337

BNC1_HUMAN

Zinc finger protein basonuclin-1

0.341

NPHN_HUMAN

Nephrin

0.341

5HT1A_HUMAN

5-hydroxytryptamine receptor 1A

0.341

RIPL1_HUMAN

RILP-like protein 1

0.361

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.361

HINFP_HUMAN

Histone H4 transcription factor

0.361

FABP7_HUMAN

Fatty acid-binding protein, brain

0.361

FBX25_HUMAN

F-box only protein 25

0.365

LMNB1_HUMAN

Lamin-B1

0.365

ZFHX3_HUMAN

Zinc finger homeobox protein 3

0.365

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.365

HXC4_HUMAN

Homeobox protein Hox-C4

0.369

RT27_HUMAN

28S ribosomal protein S27, mitochondrial

0.369

CSRN2_HUMAN

Cysteine/serine-rich nuclear protein 2

0.369

NRX2A_HUMAN

Neurexin-2

0.374

GNRHR_HUMAN

Gonadotropin-releasing hormone receptor

0.374

RM51_HUMAN

39S ribosomal protein L51, mitochondrial

0.374

CT2NL_HUMAN

CTTNBP2 N-terminal-like protein

0.374

TNNT3_HUMAN

Troponin T, fast skeletal muscle

0.378

AT1B4_HUMAN

Protein ATP1B4

0.386

BARH1_HUMAN

BarH-like 1 homeobox protein

0.386

ZFHX4_HUMAN

Zinc finger homeobox protein 4

0.386

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.386

DACH1_HUMAN

Dachshund homolog 1

0.390

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.390

LMNB2_HUMAN

Lamin-B2

0.390

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

0.390

SKI_HUMAN

Ski oncogene

0.390

MB211_HUMAN

Putative nucleotidyltransferase MAB21L1

0.390

ACK1_HUMAN

Activated CDC42 kinase 1

0.390

EHBP1_HUMAN

EH domain-binding protein 1

0.390

CD5R1_HUMAN

Cyclin-dependent kinase 5 activator 1

0.390

WAC_HUMAN

WW domain-containing adapter protein with coiled-coil

0.390

HDC_HUMAN

Headcase protein homolog

0.390

DACH2_HUMAN

Dachshund homolog 2

0.390

UNC5D_HUMAN

Netrin receptor UNC5D

0.394

CSTN3_HUMAN

Calsyntenin-3

0.394

ACM2_HUMAN

Muscarinic acetylcholine receptor M2

0.394

FBX32_HUMAN

F-box only protein 32

0.394

ACM5_HUMAN

Muscarinic acetylcholine receptor M5

0.394

RIMS3_HUMAN

Regulating synaptic membrane exocytosis protein 3

0.394

NR1H3_HUMAN

Oxysterols receptor LXR-alpha

0.394

SKIL_HUMAN

Ski-like protein

0.394

CSTN2_HUMAN

Calsyntenin-2

0.394

PP4P1_HUMAN

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.394

HXB7_HUMAN

Homeobox protein Hox-B7

0.394

SLIT1_HUMAN

Slit homolog 1 protein

0.394

PRDM1_HUMAN

PR domain zinc finger protein 1

0.394

BC11B_HUMAN

B-cell lymphoma/leukemia 11B

0.394

ACM3_HUMAN

Muscarinic acetylcholine receptor M3

0.394

UNC5C_HUMAN

Netrin receptor UNC5C

0.394

DCST2_HUMAN

DC-STAMP domain-containing protein 2

0.399

RM39_HUMAN

39S ribosomal protein L39, mitochondrial

0.399

FEZ2_HUMAN

Fasciculation and elongation protein zeta-2

0.399

TMCC3_HUMAN

Transmembrane and coiled-coil domain protein 3

0.399

TNNI2_HUMAN

Troponin I, fast skeletal muscle

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

BAF_HUMAN

Barrier-to-autointegration factor

0.377

5HT1A_HUMAN

5-hydroxytryptamine receptor 1A

0.379

FBX25_HUMAN

F-box only protein 25

0.379

BNC2_HUMAN

Zinc finger protein basonuclin-2

0.381

NDUB5_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

0.386

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.386

PHKG2_HUMAN

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

0.394

UNC5C_HUMAN

Netrin receptor UNC5C

0.398

SLIT1_HUMAN

Slit homolog 1 protein

0.398

HINFP_HUMAN

Histone H4 transcription factor

0.398

ERBB2_HUMAN

Receptor tyrosine-protein kinase erbB-2

0.399

ONEC2_HUMAN

One cut domain family member 2

0.399

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.399

NPHN_HUMAN

Nephrin

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 40 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy