RFOX1_HUMAN 2019

Gene Name RFOX1

Description RNA binding protein fox-1 homolog 1

Length 397

9606

Sequence

>sp|Q9NWB1|RFOX1_HUMAN RNA binding protein fox-1 homolog 1
MNCEREQLRGNQEAAAAPDTMAQPYASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVPEHTLNLYPPAQTHSEQSPADTSAQTVSGTATQTDDAAPTDGQPQTQPSENTENKSQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKTVNPYTNGWKLNPVVGAVYSPEFYAGTVLLCQANQEGSSMYSAPSSLVYTSAMPGFPYPAATAAAAYRGAHLRGRGRTVYNTFRAAAPPPPIPAYGGVVYQDGFYGADIYGGYAAYRYAQPTPATAAAYSDSYGRVYAADPYHHALAPAPTYGVGAMNAFAPLTDAKTRSHADDVGLVLSSLQASIYRGGYNRFAPY

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

RFOX2_HUMAN

RNA binding protein fox-1 homolog 2

0.277

RUNX2_HUMAN

Runt-related transcription factor 2

0.307

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.333

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.333

WLS_HUMAN

Protein wntless homolog

0.336

CTNA1_HUMAN

Catenin alpha-1

0.336

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.336

AP2B_HUMAN

Transcription factor AP-2-beta

0.340

ARFP1_HUMAN

Arfaptin-1

0.357

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.357

FERM2_HUMAN

Fermitin family homolog 2

0.360

SYT1_HUMAN

Synaptotagmin-1

0.360

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.360

FERM1_HUMAN

Fermitin family homolog 1

0.360

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.360

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.360

BAF_HUMAN

Barrier-to-autointegration factor

0.360

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.363

PROM1_HUMAN

Prominin-1

0.363

AT1B4_HUMAN

Protein ATP1B4

0.363

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.363

ROR1_HUMAN

Inactive tyrosine-protein kinase transmembrane receptor ROR1

0.363

RHG42_HUMAN

Rho GTPase-activating protein 42

0.363

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.363

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.363

HLF_HUMAN

Hepatic leukemia factor

0.363

JPH1_HUMAN

Junctophilin-1

0.363

NET1_HUMAN

Netrin-1

0.363

MACOI_HUMAN

Macoilin

0.363

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.363

CAPS1_HUMAN

Calcium-dependent secretion activator 1

0.363

MADD_HUMAN

MAP kinase-activating death domain protein

0.363

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.363

PARD3_HUMAN

Partitioning defective 3 homolog

0.363

RUND1_HUMAN

RUN domain-containing protein 1

0.363

WNT5A_HUMAN

Protein Wnt-5a

0.363

HTF4_HUMAN

Transcription factor 12

0.363

EHBP1_HUMAN

EH domain-binding protein 1

0.367

C43BP_HUMAN

Collagen type IV alpha-3-binding protein

0.375

PCX1_HUMAN

Pecanex-like protein 1

0.375

TFAP4_HUMAN

Transcription factor AP-4

0.378

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.378

INT13_HUMAN

Integrator complex subunit 13

0.381

ARRB2_HUMAN

Beta-arrestin-2

0.381

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.381

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.385

GFI1_HUMAN

Zinc finger protein Gfi-1

0.385

RFOX3_HUMAN

RNA binding protein fox-1 homolog 3

0.385

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.385

SETB1_HUMAN

Histone-lysine N-methyltransferase SETDB1

0.385

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.385

TGFR1_HUMAN

TGF-beta receptor type-1

0.385

BMP2_HUMAN

Bone morphogenetic protein 2

0.385

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.385

TF3C1_HUMAN

General transcription factor 3C polypeptide 1

0.385

DVL2_HUMAN

Segment polarity protein dishevelled homolog DVL-2

0.385

IRX4_HUMAN

Iroquois-class homeodomain protein IRX-4

0.385

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.385

AP2A_HUMAN

Transcription factor AP-2-alpha

0.389

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.389

TFE2_HUMAN

Transcription factor E2-alpha

0.389

JPH3_HUMAN

Junctophilin-3

0.389

FEM1C_HUMAN

Protein fem-1 homolog C

0.389

NCK2_HUMAN

Cytoplasmic protein NCK2

0.389

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.389

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.389

RN146_HUMAN

E3 ubiquitin-protein ligase RNF146

0.389

TEF_HUMAN

Thyrotroph embryonic factor

0.389

RIPL1_HUMAN

RILP-like protein 1

0.389

NR5A2_HUMAN

Nuclear receptor subfamily 5 group A member 2

0.389

FABP7_HUMAN

Fatty acid-binding protein, brain

0.389

NFIB_HUMAN

Nuclear factor 1 B-type

0.389

ITF2_HUMAN

Transcription factor 4

0.389

HINFP_HUMAN

Histone H4 transcription factor

0.389

STON1_HUMAN

Stonin-1

0.389

FA8A1_HUMAN

Protein FAM8A1

0.389

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.389

TSN5_HUMAN

Tetraspanin-5

0.389

NFIA_HUMAN

Nuclear factor 1 A-type

0.389

LIPA1_HUMAN

Liprin-alpha-1

0.389

FOXO1_HUMAN

Forkhead box protein O1

0.389

PTPRN_HUMAN

Receptor-type tyrosine-protein phosphatase-like N

0.389

VANG1_HUMAN

Vang-like protein 1

0.389

FOXO3_HUMAN

Forkhead box protein O3

0.389

SNRK_HUMAN

SNF-related serine/threonine-protein kinase

0.397

INT14_HUMAN

Integrator complex subunit 14

0.397

ARRB1_HUMAN

Beta-arrestin-1

0.397

KSR1_HUMAN

Kinase suppressor of Ras 1

0.397

ITB1_HUMAN

Integrin beta-1

0.397

SPRY7_HUMAN

SPRY domain-containing protein 7

0.397

IP3KA_HUMAN

Inositol-trisphosphate 3-kinase A

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RFOX2_HUMAN

RNA binding protein fox-1 homolog 2

0.247

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.365

HTF4_HUMAN

Transcription factor 12

0.366

ITB1_HUMAN

Integrin beta-1

0.368

RIPL1_HUMAN

RILP-like protein 1

0.373

CBLB_HUMAN

E3 ubiquitin-protein ligase CBL-B

0.373

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.374

ITF2_HUMAN

Transcription factor 4

0.375

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.377

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.377

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.380

MAGI1_HUMAN

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

0.381

RFOX3_HUMAN

RNA binding protein fox-1 homolog 3

0.381

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.381

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.381

WLS_HUMAN

Protein wntless homolog

0.382

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.382

FERM2_HUMAN

Fermitin family homolog 2

0.382

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.382

HLF_HUMAN

Hepatic leukemia factor

0.383

STON1_HUMAN

Stonin-1

0.384

SNRK_HUMAN

SNF-related serine/threonine-protein kinase

0.386

STON2_HUMAN

Stonin-2

0.386

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.387

BMP2_HUMAN

Bone morphogenetic protein 2

0.387

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.388

AT1B4_HUMAN

Protein ATP1B4

0.388

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.388

HINFP_HUMAN

Histone H4 transcription factor

0.388

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.388

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.389

RSBN1_HUMAN

Lysine-specific demethylase 9

0.389

MAPK3_HUMAN

MAP kinase-activated protein kinase 3

0.389

BICD1_HUMAN

Protein bicaudal D homolog 1

0.389

AFAD_HUMAN

Afadin

0.390

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.391

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.392

FBX25_HUMAN

F-box only protein 25

0.392

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.393

ARFP1_HUMAN

Arfaptin-1

0.393

TRIO_HUMAN

Triple functional domain protein

0.394

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.394

FERM1_HUMAN

Fermitin family homolog 1

0.394

MAPK2_HUMAN

MAP kinase-activated protein kinase 2

0.394

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.394

TNIK_HUMAN

TRAF2 and NCK-interacting protein kinase

0.394

BICD2_HUMAN

Protein bicaudal D homolog 2

0.395

CTNA1_HUMAN

Catenin alpha-1

0.395

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.395

GIT2_HUMAN

ARF GTPase-activating protein GIT2

0.395

ROR1_HUMAN

Inactive tyrosine-protein kinase transmembrane receptor ROR1

0.396

CAPS1_HUMAN

Calcium-dependent secretion activator 1

0.396

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.397

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.399

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.399

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.400

NUMB_HUMAN

Protein numb homolog

0.400

VAV2_HUMAN

Guanine nucleotide exchange factor VAV2

0.400

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.400

C43BP_HUMAN

Collagen type IV alpha-3-binding protein

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 52 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy