CLDN1_HUMAN 2019

Gene Name CLDN1

Description Claudin domain-containing protein 1

Length 253

9606

Sequence

>sp|Q9NY35|CLDN1_HUMAN Claudin domain-containing protein 1
MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDVVTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TLR5_HUMAN

Toll-like receptor 5

0.346

CADH6_HUMAN

Cadherin-6

0.346

CAD11_HUMAN

Cadherin-11

0.346

CADH2_HUMAN

Cadherin-2

0.346

CADH7_HUMAN

Cadherin-7

0.400

CAD12_HUMAN

Cadherin-12

0.400

ECM2_HUMAN

Extracellular matrix protein 2

0.400

CAD15_HUMAN

Cadherin-15

0.400

CADH4_HUMAN

Cadherin-4

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CADH2_HUMAN

Cadherin-2

0.362

CD166_HUMAN

CD166 antigen

0.365

ZN142_HUMAN

Zinc finger protein 142

0.365

JUPI2_HUMAN

Jupiter microtubule associated homolog 2

0.374

BORG2_HUMAN

Cdc42 effector protein 3

0.376

STC2_HUMAN

Stanniocalcin-2

0.376

RIC3_HUMAN

Protein RIC-3

0.376

STXB6_HUMAN

Syntaxin-binding protein 6

0.376

PENK_HUMAN

Proenkephalin-A

0.378

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.378

SYBU_HUMAN

Syntabulin

0.378

ZN131_HUMAN

Zinc finger protein 131

0.378

GHR_HUMAN

Growth hormone receptor

0.378

MERB1_HUMAN

bMERB domain-containing protein 1

0.378

MYZAP_HUMAN

Myocardial zonula adherens protein

0.378

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.378

PDGFC_HUMAN

Platelet-derived growth factor C

0.378

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.378

OCLN_HUMAN

Occludin

0.378

CALD1_HUMAN

Caldesmon

0.378

NPY_HUMAN

Pro-neuropeptide Y

0.378

ZN644_HUMAN

Zinc finger protein 644

0.378

LEG1_HUMAN

Galectin-1

0.378

NEXMI_HUMAN

Neurite extension and migration factor

0.378

PRL_HUMAN

Prolactin

0.378

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.378

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.378

TMCO6_HUMAN

Transmembrane and coiled-coil domain-containing protein 6

0.385

STC1_HUMAN

Stanniocalcin-1

0.387

NET4_HUMAN

Netrin-4

0.387

NEXN_HUMAN

Nexilin

0.387

NECT1_HUMAN

Nectin-1

0.387

GCR_HUMAN

Glucocorticoid receptor

0.389

FBLN7_HUMAN

Fibulin-7

0.389

CEP55_HUMAN

Centrosomal protein of 55 kDa

0.389

TSN12_HUMAN

Tetraspanin-12

0.389

T150A_HUMAN

Transmembrane protein 150A

0.389

CCD80_HUMAN

Coiled-coil domain-containing protein 80

0.389

NLRX1_HUMAN

NLR family member X1

0.390

EDAR_HUMAN

Tumor necrosis factor receptor superfamily member EDAR

0.390

ZN335_HUMAN

Zinc finger protein 335

0.390

ANGT_HUMAN

Angiotensinogen

0.390

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.390

TMM51_HUMAN

Transmembrane protein 51

0.390

LYRIC_HUMAN

Protein LYRIC

0.390

MNAR1_HUMAN

Major intrinsically disordered Notch2-binding receptor 1

0.390

TEFF1_HUMAN

Tomoregulin-1

0.390

ZP3_HUMAN

Zona pellucida sperm-binding protein 3

0.390

ZBT18_HUMAN

Zinc finger and BTB domain-containing protein 18

0.390

PRDM5_HUMAN

PR domain zinc finger protein 5

0.390

PTHR_HUMAN

Parathyroid hormone-related protein

0.390

FPRP_HUMAN

Prostaglandin F2 receptor negative regulator

0.390

SPIN1_HUMAN

Spindlin-1

0.390

ZBTB2_HUMAN

Zinc finger and BTB domain-containing protein 2

0.390

VCAM1_HUMAN

Vascular cell adhesion protein 1

0.390

LUZP1_HUMAN

Leucine zipper protein 1

0.390

PALMD_HUMAN

Palmdelphin

0.390

MUC18_HUMAN

Cell surface glycoprotein MUC18

0.390

CDCP1_HUMAN

CUB domain-containing protein 1

0.390

AKA11_HUMAN

A-kinase anchor protein 11

0.390

M3K8_HUMAN

Mitogen-activated protein kinase kinase kinase 8

0.390

LEPR_HUMAN

Leptin receptor

0.390

TANK_HUMAN

TRAF family member-associated NF-kappa-B activator

0.390

CAD17_HUMAN

Cadherin-17

0.390

GDNF_HUMAN

Glial cell line-derived neurotrophic factor

0.390

NYAP2_HUMAN

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

0.390

ZBT16_HUMAN

Zinc finger and BTB domain-containing protein 16

0.390

CLD11_HUMAN

Claudin-11

0.390

F131B_HUMAN

Protein FAM131B

0.390

CXCR4_HUMAN

C-X-C chemokine receptor type 4

0.390

MBP_HUMAN

Myelin basic protein

0.390

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.390

LUR1L_HUMAN

Leucine rich adaptor protein 1-like

0.390

TF_HUMAN

Tissue factor

0.390

CXD2_HUMAN

Gap junction delta-2 protein

0.390

CCR7_HUMAN

C-C chemokine receptor type 7

0.390

SMS_HUMAN

Somatostatin

0.390

ITGBL_HUMAN

Integrin beta-like protein 1

0.390

ABEC2_HUMAN

C->U-editing enzyme APOBEC-2

0.390

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.390

RAG2_HUMAN

V(D)J recombination-activating protein 2

0.390

AZI2_HUMAN

5-azacytidine-induced protein 2

0.390

FMOD_HUMAN

Fibromodulin

0.390

ZBTB1_HUMAN

Zinc finger and BTB domain-containing protein 1

0.390

F1711_HUMAN

Protein FAM171A1

0.390

BFSP1_HUMAN

Filensin

0.390

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.390

AUGN_HUMAN

Augurin

0.392

CKAP4_HUMAN

Cytoskeleton-associated protein 4

0.392

IL3RB_HUMAN

Cytokine receptor common subunit beta

0.392

CAD11_HUMAN

Cadherin-11

0.395

EURL_HUMAN

Protein EURL homolog

0.399

FABP6_HUMAN

Gastrotropin

0.399

CCG1_HUMAN

Voltage-dependent calcium channel gamma-1 subunit

0.399

NECT3_HUMAN

Nectin-3

0.399

CXB1_HUMAN

Gap junction beta-1 protein

0.399

CXAR_HUMAN

Coxsackievirus and adenovirus receptor

0.399

LEGL_HUMAN

Galectin-related protein

0.399

PI3R5_HUMAN

Phosphoinositide 3-kinase regulatory subunit 5

0.399

PCOC2_HUMAN

Procollagen C-endopeptidase enhancer 2

0.399

ZBT44_HUMAN

Zinc finger and BTB domain-containing protein 44

0.399

SH3B4_HUMAN

SH3 domain-binding protein 4

0.399

GAK1B_HUMAN

Golgi-associated kinase 1B

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 23 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy