KLH14_HUMAN 2019

Gene Name KLH14

Description Kelch-like protein 14

Length 628

9606

Sequence

>sp|Q9P2G3|KLH14_HUMAN Kelch-like protein 14
MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACVTVILPSCVPYNK

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ZBTB1_HUMAN

Zinc finger and BTB domain-containing protein 1

0.369

VCAM1_HUMAN

Vascular cell adhesion protein 1

0.369

ZBT18_HUMAN

Zinc finger and BTB domain-containing protein 18

0.369

ZN644_HUMAN

Zinc finger protein 644

0.380

CDHR1_HUMAN

Cadherin-related family member 1

0.380

NPY_HUMAN

Pro-neuropeptide Y

0.380

ZN131_HUMAN

Zinc finger protein 131

0.380

PDGFC_HUMAN

Platelet-derived growth factor C

0.380

MERB1_HUMAN

bMERB domain-containing protein 1

0.380

MFA3L_HUMAN

Microfibrillar-associated protein 3-like

0.380

PRL_HUMAN

Prolactin

0.380

LEG1_HUMAN

Galectin-1

0.380

SYBU_HUMAN

Syntabulin

0.380

ZPLD1_HUMAN

Zona pellucida-like domain-containing protein 1

0.380

P33MX_HUMAN

Putative monooxygenase p33MONOX

0.380

PENK_HUMAN

Proenkephalin-A

0.380

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.380

NEXMI_HUMAN

Neurite extension and migration factor

0.380

OCLN_HUMAN

Occludin

0.380

VSTM4_HUMAN

V-set and transmembrane domain-containing protein 4

0.380

ADNP_HUMAN

Activity-dependent neuroprotector homeobox protein

0.380

GHR_HUMAN

Growth hormone receptor

0.380

MYZAP_HUMAN

Myocardial zonula adherens protein

0.380

SCF_HUMAN

Kit ligand

0.382

REST_HUMAN

RE1-silencing transcription factor

0.382

K1107_HUMAN

AP2-interacting clathrin-endocytosis protein

0.382

OLFM4_HUMAN

Olfactomedin-4

0.382

FETUB_HUMAN

Fetuin-B

0.382

CCPG1_HUMAN

Cell cycle progression protein 1

0.382

ZBT20_HUMAN

Zinc finger and BTB domain-containing protein 20

0.382

GCR_HUMAN

Glucocorticoid receptor

0.390

ZN142_HUMAN

Zinc finger protein 142

0.390

CEP55_HUMAN

Centrosomal protein of 55 kDa

0.390

CCD80_HUMAN

Coiled-coil domain-containing protein 80

0.390

CD166_HUMAN

CD166 antigen

0.390

CXD2_HUMAN

Gap junction delta-2 protein

0.392

ZBT16_HUMAN

Zinc finger and BTB domain-containing protein 16

0.392

PALMD_HUMAN

Palmdelphin

0.392

NYAP2_HUMAN

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

0.392

TF_HUMAN

Tissue factor

0.392

AZI2_HUMAN

5-azacytidine-induced protein 2

0.392

ITGBL_HUMAN

Integrin beta-like protein 1

0.392

F131B_HUMAN

Protein FAM131B

0.392

FMOD_HUMAN

Fibromodulin

0.392

CAD17_HUMAN

Cadherin-17

0.392

PRDM5_HUMAN

PR domain zinc finger protein 5

0.392

MNAR1_HUMAN

Major intrinsically disordered Notch2-binding receptor 1

0.392

LUR1L_HUMAN

Leucine rich adaptor protein 1-like

0.392

RAG2_HUMAN

V(D)J recombination-activating protein 2

0.392

MBP_HUMAN

Myelin basic protein

0.392

ZN276_HUMAN

Zinc finger protein 276

0.392

F1711_HUMAN

Protein FAM171A1

0.392

CDCP1_HUMAN

CUB domain-containing protein 1

0.392

ABEC2_HUMAN

C->U-editing enzyme APOBEC-2

0.392

BFSP1_HUMAN

Filensin

0.392

ZP3_HUMAN

Zona pellucida sperm-binding protein 3

0.392

CCSE2_HUMAN

Serine-rich coiled-coil domain-containing protein 2

0.392

CCR7_HUMAN

C-C chemokine receptor type 7

0.392

SKA3_HUMAN

Spindle and kinetochore-associated protein 3

0.392

LUZP1_HUMAN

Leucine zipper protein 1

0.392

ZBTB2_HUMAN

Zinc finger and BTB domain-containing protein 2

0.392

M3K8_HUMAN

Mitogen-activated protein kinase kinase kinase 8

0.392

SMS_HUMAN

Somatostatin

0.392

LYRIC_HUMAN

Protein LYRIC

0.392

PHAG1_HUMAN

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

0.392

EDAR_HUMAN

Tumor necrosis factor receptor superfamily member EDAR

0.392

TMM51_HUMAN

Transmembrane protein 51

0.392

AKA11_HUMAN

A-kinase anchor protein 11

0.392

CKLF3_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 3

0.392

TANK_HUMAN

TRAF family member-associated NF-kappa-B activator

0.392

NAIF1_HUMAN

Nuclear apoptosis-inducing factor 1

0.392

CXCR4_HUMAN

C-X-C chemokine receptor type 4

0.392

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.392

PTHR_HUMAN

Parathyroid hormone-related protein

0.392

FPRP_HUMAN

Prostaglandin F2 receptor negative regulator

0.392

SPIN1_HUMAN

Spindlin-1

0.392

ZN335_HUMAN

Zinc finger protein 335

0.392

CLD11_HUMAN

Claudin-11

0.392

TEFF1_HUMAN

Tomoregulin-1

0.392

NLRX1_HUMAN

NLR family member X1

0.392

LEPR_HUMAN

Leptin receptor

0.392

GDNF_HUMAN

Glial cell line-derived neurotrophic factor

0.392

ANGT_HUMAN

Angiotensinogen

0.392

ZBT14_HUMAN

Zinc finger and BTB domain-containing protein 14

0.394

BFSP2_HUMAN

Phakinin

0.394

IL12B_HUMAN

Interleukin-12 subunit beta

0.394

ZBT41_HUMAN

Zinc finger and BTB domain-containing protein 41

0.394

MYOZ2_HUMAN

Myozenin-2

0.394

ZBT24_HUMAN

Zinc finger and BTB domain-containing protein 24

0.394

MLC1_HUMAN

Membrane protein MLC1

0.394

LBH_HUMAN

Protein LBH

0.394

GPR37_HUMAN

Prosaposin receptor GPR37

0.394

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 21 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy