FEM1B_HUMAN 2019

Gene Name FEM1B

Description Protein fem-1 homolog B

Length 627

9606

Sequence

>sp|Q9UK73|FEM1B_HUMAN Protein fem-1 homolog B
MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.323

CD5R1_HUMAN

Cyclin-dependent kinase 5 activator 1

0.326

ATIF1_HUMAN

ATPase inhibitor, mitochondrial

0.326

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.350

WLS_HUMAN

Protein wntless homolog

0.350

FEM1C_HUMAN

Protein fem-1 homolog C

0.354

RT31_HUMAN

28S ribosomal protein S31, mitochondrial

0.357

NDUBA_HUMAN

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

0.357

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.357

RM55_HUMAN

39S ribosomal protein L55, mitochondrial

0.365

AFAD_HUMAN

Afadin

0.370

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.370

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.374

RUNX2_HUMAN

Runt-related transcription factor 2

0.374

FERM1_HUMAN

Fermitin family homolog 1

0.374

FERM2_HUMAN

Fermitin family homolog 2

0.374

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.374

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.374

SYT1_HUMAN

Synaptotagmin-1

0.374

AT1B4_HUMAN

Protein ATP1B4

0.378

WNT5A_HUMAN

Protein Wnt-5a

0.378

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.378

PROM1_HUMAN

Prominin-1

0.378

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.378

HTF4_HUMAN

Transcription factor 12

0.378

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.378

JPH1_HUMAN

Junctophilin-1

0.378

PARD3_HUMAN

Partitioning defective 3 homolog

0.378

CPEB4_HUMAN

Cytoplasmic polyadenylation element-binding protein 4

0.378

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.378

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.378

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.378

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.378

RUND1_HUMAN

RUN domain-containing protein 1

0.378

NEPR1_HUMAN

Nuclear envelope phosphatase-regulatory subunit 1

0.382

SKI_HUMAN

Ski oncogene

0.382

CASP7_HUMAN

Caspase-7

0.382

MB211_HUMAN

Putative nucleotidyltransferase MAB21L1

0.382

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.382

TRAK1_HUMAN

Trafficking kinesin-binding protein 1

0.382

EHBP1_HUMAN

EH domain-binding protein 1

0.382

HDC_HUMAN

Headcase protein homolog

0.382

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.382

PP4P1_HUMAN

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.386

RT33_HUMAN

28S ribosomal protein S33, mitochondrial

0.386

ATX1_HUMAN

Ataxin-1

0.390

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.396

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.396

TGFR1_HUMAN

TGF-beta receptor type-1

0.400

SETB1_HUMAN

Histone-lysine N-methyltransferase SETDB1

0.400

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.400

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.400

GFI1_HUMAN

Zinc finger protein Gfi-1

0.400

CTNA1_HUMAN

Catenin alpha-1

0.400

BMP2_HUMAN

Bone morphogenetic protein 2

0.400

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.400

IRX4_HUMAN

Iroquois-class homeodomain protein IRX-4

0.400

RIMB2_HUMAN

RIMS-binding protein 2

0.400

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.337

FEM1C_HUMAN

Protein fem-1 homolog C

0.350

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.354

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.358

HDC_HUMAN

Headcase protein homolog

0.359

WLS_HUMAN

Protein wntless homolog

0.360

BMP2_HUMAN

Bone morphogenetic protein 2

0.365

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.367

ILF2_HUMAN

Interleukin enhancer-binding factor 2

0.367

ITB1_HUMAN

Integrin beta-1

0.370

PP4P2_HUMAN

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

0.374

ITB3_HUMAN

Integrin beta-3

0.378

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.378

AT1B4_HUMAN

Protein ATP1B4

0.378

PARD3_HUMAN

Partitioning defective 3 homolog

0.378

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.378

PICK1_HUMAN

PRKCA-binding protein

0.378

HINFP_HUMAN

Histone H4 transcription factor

0.378

BMP4_HUMAN

Bone morphogenetic protein 4

0.379

RUND1_HUMAN

RUN domain-containing protein 1

0.380

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.380

AFAD_HUMAN

Afadin

0.381

MIER3_HUMAN

Mesoderm induction early response protein 3

0.381

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.383

ARFP1_HUMAN

Arfaptin-1

0.383

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.383

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.383

TRIO_HUMAN

Triple functional domain protein

0.384

FERM2_HUMAN

Fermitin family homolog 2

0.384

FERM1_HUMAN

Fermitin family homolog 1

0.384

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.384

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.385

LRRF2_HUMAN

Leucine-rich repeat flightless-interacting protein 2

0.386

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.386

BCL7B_HUMAN

B-cell CLL/lymphoma 7 protein family member B

0.386

SETB1_HUMAN

Histone-lysine N-methyltransferase SETDB1

0.387

KBRS2_HUMAN

NF-kappa-B inhibitor-interacting Ras-like protein 2

0.387

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.388

PDXD1_HUMAN

Pyridoxal-dependent decarboxylase domain-containing protein 1

0.389

ROBO1_HUMAN

Roundabout homolog 1

0.389

WAC_HUMAN

WW domain-containing adapter protein with coiled-coil

0.389

SC5A8_HUMAN

Sodium-coupled monocarboxylate transporter 1

0.389

MIGA2_HUMAN

Mitoguardin 2

0.389

NUMB_HUMAN

Protein numb homolog

0.390

GLCE_HUMAN

D-glucuronyl C5-epimerase

0.390

RSBN1_HUMAN

Lysine-specific demethylase 9

0.390

APBA1_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 1

0.390

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.390

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.390

TRAK1_HUMAN

Trafficking kinesin-binding protein 1

0.391

JKAMP_HUMAN

JNK1/MAPK8-associated membrane protein

0.392

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.393

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.394

CSPG4_HUMAN

Chondroitin sulfate proteoglycan 4

0.394

DVL3_HUMAN

Segment polarity protein dishevelled homolog DVL-3

0.395

PAR3L_HUMAN

Partitioning defective 3 homolog B

0.395

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.395

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.395

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.395

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.395

RASF8_HUMAN

Ras association domain-containing protein 8

0.396

K2013_HUMAN

Uncharacterized protein KIAA2013

0.396

MIGA1_HUMAN

Mitoguardin 1

0.396

SNX5_HUMAN

Sorting nexin-5

0.396

MADD_HUMAN

MAP kinase-activating death domain protein

0.396

GO45_HUMAN

Golgin-45

0.397

RIPL1_HUMAN

RILP-like protein 1

0.397

SMAD5_HUMAN

Mothers against decapentaplegic homolog 5

0.398

CSKP_HUMAN

Peripheral plasma membrane protein CASK

0.399

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.399

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.400

MIER1_HUMAN

Mesoderm induction early response protein 1

0.400

RT35_HUMAN

28S ribosomal protein S35, mitochondrial

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 44 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy