3BP1_HUMAN 2019

Gene Name 3BP1

Description SH3 domain-binding protein 1

Length 701

9606

Sequence

>sp|Q9Y3L3|3BP1_HUMAN SH3 domain-binding protein 1
MMKRQLHRMRQLAQTGSLGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHSHTTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRRSLSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGLFSAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRSPASPSPASPGPASPSPVSLSNPAQVDLGAATAEGGAPEAISGVPTPPAIPPQPRPRSLASETN

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

RHG17_HUMAN

Rho GTPase-activating protein 17

0.387

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RHG17_HUMAN

Rho GTPase-activating protein 17

0.314

RHG44_HUMAN

Rho GTPase-activating protein 44

0.321

CBL_HUMAN

E3 ubiquitin-protein ligase CBL

0.355

SNX5_HUMAN

Sorting nexin-5

0.357

ERP44_HUMAN

Endoplasmic reticulum resident protein 44

0.360

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.362

NDST1_HUMAN

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

0.365

PDC10_HUMAN

Programmed cell death protein 10

0.367

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.368

AT1B4_HUMAN

Protein ATP1B4

0.374

CACB2_HUMAN

Voltage-dependent L-type calcium channel subunit beta-2

0.374

NUMB_HUMAN

Protein numb homolog

0.374

ST7_HUMAN

Suppressor of tumorigenicity 7 protein

0.374

PCX1_HUMAN

Pecanex-like protein 1

0.378

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.379

RSBNL_HUMAN

Round spermatid basic protein 1-like protein

0.379

TAOK3_HUMAN

Serine/threonine-protein kinase TAO3

0.379

CACB4_HUMAN

Voltage-dependent L-type calcium channel subunit beta-4

0.380

WLS_HUMAN

Protein wntless homolog

0.380

SNX27_HUMAN

Sorting nexin-27

0.380

CTNA1_HUMAN

Catenin alpha-1

0.381

FHOD3_HUMAN

FH1/FH2 domain-containing protein 3

0.383

MAGI3_HUMAN

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

0.384

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.385

PICK1_HUMAN

PRKCA-binding protein

0.385

ANKL2_HUMAN

Ankyrin repeat and LEM domain-containing protein 2

0.385

SNX6_HUMAN

Sorting nexin-6

0.386

RIMB2_HUMAN

RIMS-binding protein 2

0.386

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.386

BMP4_HUMAN

Bone morphogenetic protein 4

0.386

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.386

AFAD_HUMAN

Afadin

0.387

NDUAA_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

0.387

ITB1_HUMAN

Integrin beta-1

0.388

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.388

PACS1_HUMAN

Phosphofurin acidic cluster sorting protein 1

0.388

IP3KB_HUMAN

Inositol-trisphosphate 3-kinase B

0.388

HS2ST_HUMAN

Heparan sulfate 2-O-sulfotransferase 1

0.388

SMCE1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

0.389

TAOK1_HUMAN

Serine/threonine-protein kinase TAO1

0.389

ARFP1_HUMAN

Arfaptin-1

0.390

WDR37_HUMAN

WD repeat-containing protein 37

0.390

APBA2_HUMAN

Amyloid-beta A4 precursor protein-binding family A member 2

0.391

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.391

OFUT1_HUMAN

GDP-fucose protein O-fucosyltransferase 1

0.391

NDST2_HUMAN

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

0.392

UNC79_HUMAN

Protein unc-79 homolog

0.393

ANKF1_HUMAN

Ankyrin repeat and fibronectin type-III domain-containing protein 1

0.394

TM129_HUMAN

E3 ubiquitin-protein ligase TM129

0.394

SNRK_HUMAN

SNF-related serine/threonine-protein kinase

0.394

RIMS4_HUMAN

Regulating synaptic membrane exocytosis protein 4

0.395

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.395

ARRB1_HUMAN

Beta-arrestin-1

0.395

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.395

BMP2_HUMAN

Bone morphogenetic protein 2

0.395

ITB3_HUMAN

Integrin beta-3

0.396

MIGA2_HUMAN

Mitoguardin 2

0.396

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.396

PACN3_HUMAN

Protein kinase C and casein kinase substrate in neurons protein 3

0.396

NEPR1_HUMAN

Nuclear envelope phosphatase-regulatory subunit 1

0.396

RSBN1_HUMAN

Lysine-specific demethylase 9

0.397

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.397

ARFP2_HUMAN

Arfaptin-2

0.397

C43BP_HUMAN

Collagen type IV alpha-3-binding protein

0.397

RUND1_HUMAN

RUN domain-containing protein 1

0.398

BICD1_HUMAN

Protein bicaudal D homolog 1

0.398

AT1B3_HUMAN

Sodium/potassium-transporting ATPase subunit beta-3

0.398

STK10_HUMAN

Serine/threonine-protein kinase 10

0.398

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.398

HTF4_HUMAN

Transcription factor 12

0.398

MACOI_HUMAN

Macoilin

0.399

LIPA1_HUMAN

Liprin-alpha-1

0.399

BAF_HUMAN

Barrier-to-autointegration factor

0.399

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.400

RUNX3_HUMAN

Runt-related transcription factor 3

0.400

JPH1_HUMAN

Junctophilin-1

0.400

MAGI1_HUMAN

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 200 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy