KCNE3_HUMAN 2019

Gene Name KCNE3

Description Potassium voltage-gated channel subfamily E member 3

Length 103

9606

Sequence

>sp|Q9Y6H6|KCNE3_HUMAN Potassium voltage-gated channel subfamily E member 3
METTNGTETWYESLHAVLKALNATLHSNLLCRPGPGLGPDNQTEERRASLPGRDDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSMI

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

IRAK2_HUMAN

Interleukin-1 receptor-associated kinase-like 2

0.277

CKLF6_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 6

0.277

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.277

IGSF1_HUMAN

Immunoglobulin superfamily member 1

0.277

INGR1_HUMAN

Interferon gamma receptor 1

0.277

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.277

ZN654_HUMAN

Zinc finger protein 654

0.277

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.277

LPAR5_HUMAN

Lysophosphatidic acid receptor 5

0.277

XKR2_HUMAN

XK-related protein 2

0.277

IL22_HUMAN

Interleukin-22

0.277

ACRO_HUMAN

Acrosin

0.277

2B1F_HUMAN

HLA class II histocompatibility antigen, DRB1-15 beta chain

0.289

IFNL3_HUMAN

Interferon lambda-3

0.289

CC160_HUMAN

Coiled-coil domain-containing protein 160

0.289

DRB3_HUMAN

HLA class II histocompatibility antigen, DR beta 3 chain

0.289

IFNL1_HUMAN

Interferon lambda-1

0.289

CD8B_HUMAN

T-cell surface glycoprotein CD8 beta chain

0.289

CD8B2_HUMAN

Putative T-cell surface glycoprotein CD8 beta-2 chain

0.289

DQB2_HUMAN

HLA class II histocompatibility antigen, DQ beta 2 chain

0.289

SCRG1_HUMAN

Scrapie-responsive protein 1

0.378

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.378

ROBO4_HUMAN

Roundabout homolog 4

0.378

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.378

MSLN_HUMAN

Mesothelin

0.378

TRI14_HUMAN

Tripartite motif-containing protein 14

0.378

F13B_HUMAN

Coagulation factor XIII B chain

0.378

VWCE_HUMAN

von Willebrand factor C and EGF domain-containing protein

0.378

SN_HUMAN

Sialoadhesin

0.378

THY1_HUMAN

Thy-1 membrane glycoprotein

0.378

C1QB_HUMAN

Complement C1q subcomponent subunit B

0.378

MO2R2_HUMAN

Cell surface glycoprotein CD200 receptor 2

0.378

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.378

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.378

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.378

STAP1_HUMAN

Signal-transducing adaptor protein 1

0.378

CLD16_HUMAN

Claudin-16

0.378

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.378

C1S_HUMAN

Complement C1s subcomponent

0.378

PIANP_HUMAN

PILR alpha-associated neural protein

0.378

PRIO_HUMAN

Major prion protein

0.392

GHRL_HUMAN

Appetite-regulating hormone

0.392

EGLN_HUMAN

Endoglin

0.392

ACRBP_HUMAN

Acrosin-binding protein

0.392

TM52B_HUMAN

Transmembrane protein 52B

0.392

APOA1_HUMAN

Apolipoprotein A-I

0.392

O11A1_HUMAN

Olfactory receptor 11A1

0.392

CD8A_HUMAN

T-cell surface glycoprotein CD8 alpha chain

0.392

TMM54_HUMAN

Transmembrane protein 54

0.392

INAR2_HUMAN

Interferon alpha/beta receptor 2

0.392

L37A1_HUMAN

Leucine-rich repeat-containing protein 37A

0.392

SACA1_HUMAN

Sperm acrosome membrane-associated protein 1

0.392

OPT_HUMAN

Opticin

0.392

O52B2_HUMAN

Olfactory receptor 52B2

0.392

DRB5_HUMAN

HLA class II histocompatibility antigen, DR beta 5 chain

0.392

Z518B_HUMAN

Zinc finger protein 518B

0.392

GP1BA_HUMAN

Platelet glycoprotein Ib alpha chain

0.392

BPIB4_HUMAN

BPI fold-containing family B member 4

0.392

PSPC_HUMAN

Pulmonary surfactant-associated protein C

0.392

IQCJ_HUMAN

IQ domain-containing protein J

0.392

A0A0G2JMZ2_HUMAN

Uncharacterized protein

0.392

ZSWM9_HUMAN

Uncharacterized protein ZSWIM9

0.392

VSIG4_HUMAN

V-set and immunoglobulin domain-containing protein 4

0.392

SIAL_HUMAN

Bone sialoprotein 2

0.392

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.392

L37A3_HUMAN

Leucine-rich repeat-containing protein 37A3

0.392

MYOZ3_HUMAN

Myozenin-3

0.392

MB214_HUMAN

Protein mab-21-like 4

0.392

L37A2_HUMAN

Leucine-rich repeat-containing protein 37A2

0.392

CK091_HUMAN

Uncharacterized protein C11orf91

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

PRIO_HUMAN

Major prion protein

0.336

INGR1_HUMAN

Interferon gamma receptor 1

0.346

CD72_HUMAN

B-cell differentiation antigen CD72

0.351

THY1_HUMAN

Thy-1 membrane glycoprotein

0.365

IL22_HUMAN

Interleukin-22

0.368

S10AB_HUMAN

Protein S100-A11

0.368

LIF_HUMAN

Leukemia inhibitory factor

0.368

INLR1_HUMAN

Interferon lambda receptor 1

0.370

IFNG_HUMAN

Interferon gamma

0.370

SUGP2_HUMAN

SURP and G-patch domain-containing protein 2

0.378

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.378

OR6B1_HUMAN

Olfactory receptor 6B1

0.378

INAR1_HUMAN

Interferon alpha/beta receptor 1

0.378

CD34_HUMAN

Hematopoietic progenitor cell antigen CD34

0.380

CLD16_HUMAN

Claudin-16

0.380

BPIB4_HUMAN

BPI fold-containing family B member 4

0.383

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.383

PIANP_HUMAN

PILR alpha-associated neural protein

0.383

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.383

CF132_HUMAN

Uncharacterized protein C6orf132

0.383

TM52B_HUMAN

Transmembrane protein 52B

0.386

CKLF6_HUMAN

CKLF-like MARVEL transmembrane domain-containing protein 6

0.386

I10R1_HUMAN

Interleukin-10 receptor subunit alpha

0.386

EGLN_HUMAN

Endoglin

0.386

CAMP_HUMAN

Cathelicidin antimicrobial peptide

0.386

CC198_HUMAN

Uncharacterized protein CCDC198

0.391

VTDB_HUMAN

Vitamin D-binding protein

0.392

IL5RA_HUMAN

Interleukin-5 receptor subunit alpha

0.392

PDPN_HUMAN

Podoplanin

0.394

GSG1_HUMAN

Germ cell-specific gene 1 protein

0.397

RESF1_HUMAN

Retroelement silencing factor 1

0.400

RAI3_HUMAN

Retinoic acid-induced protein 3

0.400

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.400

ACRBP_HUMAN

Acrosin-binding protein

0.400

TREM2_HUMAN

Triggering receptor expressed on myeloid cells 2

0.400

CD8B2_HUMAN

Putative T-cell surface glycoprotein CD8 beta-2 chain

0.400

INGR2_HUMAN

Interferon gamma receptor 2

0.400

TRI14_HUMAN

Tripartite motif-containing protein 14

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 12 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy