PAX6_HUMAN 2019

Gene Name PAX6

Description Paired box protein Pax-6

Length 422

9606

Sequence

>sp|P26367|PAX6_HUMAN Paired box protein Pax-6
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

E41L1_HUMAN

Band 4.1-like protein 1

0.292

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.323

FERM1_HUMAN

Fermitin family homolog 1

0.346

FERM2_HUMAN

Fermitin family homolog 2

0.346

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.350

AT1B4_HUMAN

Protein ATP1B4

0.350

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.350

NUMB_HUMAN

Protein numb homolog

0.350

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.350

BMP7_HUMAN

Bone morphogenetic protein 7

0.350

RUND1_HUMAN

RUN domain-containing protein 1

0.350

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.354

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.354

ACK1_HUMAN

Activated CDC42 kinase 1

0.354

NFASC_HUMAN

Neurofascin

0.354

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.357

GFI1_HUMAN

Zinc finger protein Gfi-1

0.374

BMP2_HUMAN

Bone morphogenetic protein 2

0.374

IRX4_HUMAN

Iroquois-class homeodomain protein IRX-4

0.374

TGFR1_HUMAN

TGF-beta receptor type-1

0.374

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.374

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.374

WLS_HUMAN

Protein wntless homolog

0.374

TF7L2_HUMAN

Transcription factor 7-like 2

0.374

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.374

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.374

HINFP_HUMAN

Histone H4 transcription factor

0.378

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.378

BMP5_HUMAN

Bone morphogenetic protein 5

0.378

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.378

EGR1_HUMAN

Early growth response protein 1

0.378

ZO1_HUMAN

Tight junction protein ZO-1

0.378

VANG1_HUMAN

Vang-like protein 1

0.378

E41L5_HUMAN

Band 4.1-like protein 5

0.378

RIPL1_HUMAN

RILP-like protein 1

0.378

EMX2_HUMAN

Homeobox protein EMX2

0.378

FABP7_HUMAN

Fatty acid-binding protein, brain

0.378

STON1_HUMAN

Stonin-1

0.378

VANG2_HUMAN

Vang-like protein 2

0.382

AHR_HUMAN

Aryl hydrocarbon receptor

0.382

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.382

TPD54_HUMAN

Tumor protein D54

0.382

TPD52_HUMAN

Tumor protein D52

0.382

ICA69_HUMAN

Islet cell autoantigen 1

0.382

TPD53_HUMAN

Tumor protein D53

0.382

DLX1_HUMAN

Homeobox protein DLX-1

0.382

FBX25_HUMAN

F-box only protein 25

0.382

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.382

SP9_HUMAN

Transcription factor Sp9

0.382

PROX1_HUMAN

Prospero homeobox protein 1

0.386

MYT1_HUMAN

Myelin transcription factor 1

0.386

SP8_HUMAN

Transcription factor Sp8

0.386

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.386

AFAD_HUMAN

Afadin

0.392

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.392

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.396

LEF1_HUMAN

Lymphoid enhancer-binding factor 1

0.396

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.396

SYT1_HUMAN

Synaptotagmin-1

0.396

MAN1_HUMAN

Inner nuclear membrane protein Man1

0.396

RUNX2_HUMAN

Runt-related transcription factor 2

0.396

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.396

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.400

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.400

ROR1_HUMAN

Inactive tyrosine-protein kinase transmembrane receptor ROR1

0.400

MACOI_HUMAN

Macoilin

0.400

HTF4_HUMAN

Transcription factor 12

0.400

JPH1_HUMAN

Junctophilin-1

0.400

BARH1_HUMAN

BarH-like 1 homeobox protein

0.400

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.400

NEB2_HUMAN

Neurabin-2

0.400

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.400

MADD_HUMAN

MAP kinase-activating death domain protein

0.400

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.400

NET1_HUMAN

Netrin-1

0.400

BMP4_HUMAN

Bone morphogenetic protein 4

0.400

CPEB4_HUMAN

Cytoplasmic polyadenylation element-binding protein 4

0.400

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.400

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.400

WNT5A_HUMAN

Protein Wnt-5a

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

E41L1_HUMAN

Band 4.1-like protein 1

0.292

RIMS2_HUMAN

Regulating synaptic membrane exocytosis protein 2

0.323

FERM1_HUMAN

Fermitin family homolog 1

0.346

FERM2_HUMAN

Fermitin family homolog 2

0.346

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.350

AT1B4_HUMAN

Protein ATP1B4

0.350

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.350

NUMB_HUMAN

Protein numb homolog

0.350

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.350

BMP7_HUMAN

Bone morphogenetic protein 7

0.350

RUND1_HUMAN

RUN domain-containing protein 1

0.350

FLI1_HUMAN

Friend leukemia integration 1 transcription factor

0.354

RIMS1_HUMAN

Regulating synaptic membrane exocytosis protein 1

0.354

ACK1_HUMAN

Activated CDC42 kinase 1

0.354

NFASC_HUMAN

Neurofascin

0.354

MYT1L_HUMAN

Myelin transcription factor 1-like protein

0.357

GFI1_HUMAN

Zinc finger protein Gfi-1

0.374

BMP2_HUMAN

Bone morphogenetic protein 2

0.374

IRX4_HUMAN

Iroquois-class homeodomain protein IRX-4

0.374

TGFR1_HUMAN

TGF-beta receptor type-1

0.374

NLK_HUMAN

Serine/threonine-protein kinase NLK

0.374

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.374

WLS_HUMAN

Protein wntless homolog

0.374

TF7L2_HUMAN

Transcription factor 7-like 2

0.374

PAR6B_HUMAN

Partitioning defective 6 homolog beta

0.374

MED19_HUMAN

Mediator of RNA polymerase II transcription subunit 19

0.374

HINFP_HUMAN

Histone H4 transcription factor

0.378

ROR2_HUMAN

Tyrosine-protein kinase transmembrane receptor ROR2

0.378

BMP5_HUMAN

Bone morphogenetic protein 5

0.378

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.378

EGR1_HUMAN

Early growth response protein 1

0.378

ZO1_HUMAN

Tight junction protein ZO-1

0.378

VANG1_HUMAN

Vang-like protein 1

0.378

E41L5_HUMAN

Band 4.1-like protein 5

0.378

RIPL1_HUMAN

RILP-like protein 1

0.378

EMX2_HUMAN

Homeobox protein EMX2

0.378

FABP7_HUMAN

Fatty acid-binding protein, brain

0.378

STON1_HUMAN

Stonin-1

0.378

VANG2_HUMAN

Vang-like protein 2

0.382

AHR_HUMAN

Aryl hydrocarbon receptor

0.382

MECOM_HUMAN

Histone-lysine N-methyltransferase MECOM

0.382

TPD54_HUMAN

Tumor protein D54

0.382

TPD52_HUMAN

Tumor protein D52

0.382

ICA69_HUMAN

Islet cell autoantigen 1

0.382

TPD53_HUMAN

Tumor protein D53

0.382

DLX1_HUMAN

Homeobox protein DLX-1

0.382

FBX25_HUMAN

F-box only protein 25

0.382

ELF2_HUMAN

ETS-related transcription factor Elf-2

0.382

SP9_HUMAN

Transcription factor Sp9

0.382

PROX1_HUMAN

Prospero homeobox protein 1

0.386

MYT1_HUMAN

Myelin transcription factor 1

0.386

SP8_HUMAN

Transcription factor Sp8

0.386

ST18_HUMAN

Suppression of tumorigenicity 18 protein

0.386

AFAD_HUMAN

Afadin

0.392

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.392

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.396

LEF1_HUMAN

Lymphoid enhancer-binding factor 1

0.396

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.396

SYT1_HUMAN

Synaptotagmin-1

0.396

MAN1_HUMAN

Inner nuclear membrane protein Man1

0.396

RUNX2_HUMAN

Runt-related transcription factor 2

0.396

TM38B_HUMAN

Trimeric intracellular cation channel type B

0.396

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.400

RT25_HUMAN

28S ribosomal protein S25, mitochondrial

0.400

ROR1_HUMAN

Inactive tyrosine-protein kinase transmembrane receptor ROR1

0.400

MACOI_HUMAN

Macoilin

0.400

HTF4_HUMAN

Transcription factor 12

0.400

JPH1_HUMAN

Junctophilin-1

0.400

BARH1_HUMAN

BarH-like 1 homeobox protein

0.400

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.400

NEB2_HUMAN

Neurabin-2

0.400

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.400

MADD_HUMAN

MAP kinase-activating death domain protein

0.400

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.400

NET1_HUMAN

Netrin-1

0.400

BMP4_HUMAN

Bone morphogenetic protein 4

0.400

CPEB4_HUMAN

Cytoplasmic polyadenylation element-binding protein 4

0.400

TM38A_HUMAN

Trimeric intracellular cation channel type A

0.400

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.400

WNT5A_HUMAN

Protein Wnt-5a

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 45 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy