ZP2_HUMAN 2019

Gene Name ZP2

Description Zona pellucida sperm-binding protein 2

Length 745

9606

Sequence

>sp|Q05996|ZP2_HUMAN Zona pellucida sperm-binding protein 2
MACRQRGGSWSPSGWFNAGWSTYRSISLFFALVTSGNSIDVSQLVNPAFPGTVTCDEREITVEFPSSPGTKKWHASVVDPLGLDMPNCTYILDPEKLTLRATYDNCTRRVHGGHQMTIRVMNNSAALRHGAVMYQFFCPAMQVEETQGLSASTICQKDFMSFSLPRVFSGLADDSKGTKVQMGWSIEVGDGARAKTLTLPEAMKEGFSLLIDNHRMTFHVPFNATGVTHYVQGNSHLYMVSLKLTFISPGQKVIFSSQAICAPDPVTCNATHMTLTIPEFPGKLKSVSFENQNIDVSQLHDNGIDLEATNGMKLHFSKTLLKTKLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNSSCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLGPFTLILQSYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVGSSVTHPDHYQRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRGVGSSDLKASGSSGEKSRSETGEEVGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NSG1_HUMAN

Neuronal vesicle trafficking-associated protein 1

0.250

TMG1_HUMAN

Transmembrane gamma-carboxyglutamic acid protein 1

0.250

RAB44_HUMAN

Ras-related protein Rab-44

0.250

ZFX_HUMAN

Zinc finger X-chromosomal protein

0.250

CSF3_HUMAN

Granulocyte colony-stimulating factor

0.250

PIANP_HUMAN

PILR alpha-associated neural protein

0.258

AREG_HUMAN

Amphiregulin

0.258

MO2R2_HUMAN

Cell surface glycoprotein CD200 receptor 2

0.258

MSLN_HUMAN

Mesothelin

0.258

VWCE_HUMAN

von Willebrand factor C and EGF domain-containing protein

0.258

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.258

THY1_HUMAN

Thy-1 membrane glycoprotein

0.258

CLD16_HUMAN

Claudin-16

0.258

TRI14_HUMAN

Tripartite motif-containing protein 14

0.258

TM159_HUMAN

Promethin

0.343

AMER2_HUMAN

APC membrane recruitment protein 2

0.343

T3JAM_HUMAN

TRAF3-interacting JNK-activating modulator

0.343

TNAP2_HUMAN

Tumor necrosis factor alpha-induced protein 2

0.343

LRC19_HUMAN

Leucine-rich repeat-containing protein 19

0.343

UIF_HUMAN

UAP56-interacting factor

0.343

TIRAP_HUMAN

Toll/interleukin-1 receptor domain-containing adapter protein

0.343

IL1R2_HUMAN

Interleukin-1 receptor type 2

0.343

TOX2_HUMAN

TOX high mobility group box family member 2

0.343

MEDAG_HUMAN

Mesenteric estrogen-dependent adipogenesis protein

0.354

CD6_HUMAN

T-cell differentiation antigen CD6

0.354

CODA1_HUMAN

Collagen alpha-1(XIII) chain

0.354

AGRE2_HUMAN

Adhesion G protein-coupled receptor E2

0.354

BCLF1_HUMAN

Bcl-2-associated transcription factor 1

0.354

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.354

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.354

LAG3_HUMAN

Lymphocyte activation gene 3 protein

0.354

EREG_HUMAN

Proepiregulin

0.354

GIMD1_HUMAN

GTPase IMAP family member GIMD1

0.365

ICAM5_HUMAN

Intercellular adhesion molecule 5

0.365

IL22_HUMAN

Interleukin-22

0.365

ZBTB6_HUMAN

Zinc finger and BTB domain-containing protein 6

0.365

IGSF1_HUMAN

Immunoglobulin superfamily member 1

0.365

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.365

IRAK2_HUMAN

Interleukin-1 receptor-associated kinase-like 2

0.365

AKND1_HUMAN

Protein AKNAD1

0.365

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.365

XKR2_HUMAN

XK-related protein 2

0.365

INGR1_HUMAN

Interferon gamma receptor 1

0.365

ICOSL_HUMAN

ICOS ligand

0.365

PRR36_HUMAN

Proline-rich protein 36

0.365

LPAR5_HUMAN

Lysophosphatidic acid receptor 5

0.365

CCD68_HUMAN

Coiled-coil domain-containing protein 68

0.365

INGR2_HUMAN

Interferon gamma receptor 2

0.365

CNCG_HUMAN

Retinal cone rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.365

ZN654_HUMAN

Zinc finger protein 654

0.365

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.365

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NSG1_HUMAN

Neuronal vesicle trafficking-associated protein 1

0.250

TMG1_HUMAN

Transmembrane gamma-carboxyglutamic acid protein 1

0.250

RAB44_HUMAN

Ras-related protein Rab-44

0.250

ZFX_HUMAN

Zinc finger X-chromosomal protein

0.250

CSF3_HUMAN

Granulocyte colony-stimulating factor

0.250

PIANP_HUMAN

PILR alpha-associated neural protein

0.258

AREG_HUMAN

Amphiregulin

0.258

MO2R2_HUMAN

Cell surface glycoprotein CD200 receptor 2

0.258

MSLN_HUMAN

Mesothelin

0.258

VWCE_HUMAN

von Willebrand factor C and EGF domain-containing protein

0.258

MFAP3_HUMAN

Microfibril-associated glycoprotein 3

0.258

THY1_HUMAN

Thy-1 membrane glycoprotein

0.258

CLD16_HUMAN

Claudin-16

0.258

TRI14_HUMAN

Tripartite motif-containing protein 14

0.258

TM159_HUMAN

Promethin

0.343

AMER2_HUMAN

APC membrane recruitment protein 2

0.343

T3JAM_HUMAN

TRAF3-interacting JNK-activating modulator

0.343

TNAP2_HUMAN

Tumor necrosis factor alpha-induced protein 2

0.343

LRC19_HUMAN

Leucine-rich repeat-containing protein 19

0.343

UIF_HUMAN

UAP56-interacting factor

0.343

TIRAP_HUMAN

Toll/interleukin-1 receptor domain-containing adapter protein

0.343

IL1R2_HUMAN

Interleukin-1 receptor type 2

0.343

TOX2_HUMAN

TOX high mobility group box family member 2

0.343

MEDAG_HUMAN

Mesenteric estrogen-dependent adipogenesis protein

0.354

CD6_HUMAN

T-cell differentiation antigen CD6

0.354

CODA1_HUMAN

Collagen alpha-1(XIII) chain

0.354

AGRE2_HUMAN

Adhesion G protein-coupled receptor E2

0.354

BCLF1_HUMAN

Bcl-2-associated transcription factor 1

0.354

CD28_HUMAN

T-cell-specific surface glycoprotein CD28

0.354

TNF15_HUMAN

Tumor necrosis factor ligand superfamily member 15

0.354

LAG3_HUMAN

Lymphocyte activation gene 3 protein

0.354

EREG_HUMAN

Proepiregulin

0.354

GIMD1_HUMAN

GTPase IMAP family member GIMD1

0.365

ICAM5_HUMAN

Intercellular adhesion molecule 5

0.365

IL22_HUMAN

Interleukin-22

0.365

ZBTB6_HUMAN

Zinc finger and BTB domain-containing protein 6

0.365

IGSF1_HUMAN

Immunoglobulin superfamily member 1

0.365

TAF1D_HUMAN

TATA box-binding protein-associated factor RNA polymerase I subunit D

0.365

IRAK2_HUMAN

Interleukin-1 receptor-associated kinase-like 2

0.365

AKND1_HUMAN

Protein AKNAD1

0.365

I13R1_HUMAN

Interleukin-13 receptor subunit alpha-1

0.365

XKR2_HUMAN

XK-related protein 2

0.365

INGR1_HUMAN

Interferon gamma receptor 1

0.365

ICOSL_HUMAN

ICOS ligand

0.365

PRR36_HUMAN

Proline-rich protein 36

0.365

LPAR5_HUMAN

Lysophosphatidic acid receptor 5

0.365

CCD68_HUMAN

Coiled-coil domain-containing protein 68

0.365

INGR2_HUMAN

Interferon gamma receptor 2

0.365

CNCG_HUMAN

Retinal cone rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma

0.365

ZN654_HUMAN

Zinc finger protein 654

0.365

LAPM5_HUMAN

Lysosomal-associated transmembrane protein 5

0.365

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 15 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy