MTFR1_HUMAN 2019

Gene Name MTFR1

Description Mitochondrial fission regulator 1

Length 333

9606

Sequence

>sp|Q15390|MTFR1_HUMAN Mitochondrial fission regulator 1
MLGWIKRLIRMVFQQVGVSMQSVLWSRKPYGSSRSIVRKIGTNLSLIQCPRVQFQINSHATEWSPSHPGEDAVASFADVGWVAKEEGECSARLRTEVRSRPPLQDDLLFFEKAPSRQISLPDLSQEEPQLKTPALANEEALQKICALENELAALRAQIAKIVTQQEQQNLTAGDLDSTTFGTIPPHPPPPPPPLPPPALGLHQSTSAVDLIKERREKRANAGKTLVKNNPKKPEMPNMLEILKEMNSVKLRSVKRSEQDVKPKPVDATDPAALIAEALKKKFAYRYRSDSQDEVEKGIPKSESEATSERVLFGPHMLKPTGKMKALIENVSDS

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

FBX41_HUMAN

F-box only protein 41

0.283

HRH2_HUMAN

Histamine H2 receptor

0.289

PEAK1_HUMAN

Inactive tyrosine-protein kinase PEAK1

0.289

FANCB_HUMAN

Fanconi anemia group B protein

0.289

FP100_HUMAN

Fanconi anemia core complex-associated protein 100

0.295

IL17F_HUMAN

Interleukin-17F

0.295

SHLD2_HUMAN

Shieldin complex subunit 2

0.295

SPICE_HUMAN

Spindle and centriole-associated protein 1

0.340

SFRP3_HUMAN

Secreted frizzled-related protein 3

0.346

NSMF_HUMAN

NMDA receptor synaptonuclear signaling and neuronal migration factor

0.346

PRSR1_HUMAN

Proline and serine-rich protein 1

0.354

PRAG1_HUMAN

Inactive tyrosine-protein kinase PRAG1

0.354

BEND3_HUMAN

BEN domain-containing protein 3

0.354

PIT1_HUMAN

Pituitary-specific positive transcription factor 1

0.354

TGFB2_HUMAN

Transforming growth factor beta-2 proprotein

0.354

HNMT_HUMAN

Histamine N-methyltransferase

0.354

PKR2_HUMAN

Prokineticin receptor 2

0.354

TM206_HUMAN

Transmembrane protein 206

0.361

SMI19_HUMAN

Small integral membrane protein 19

0.361

BEND7_HUMAN

BEN domain-containing protein 7

0.361

CJ088_HUMAN

Uncharacterized protein C10orf88

0.361

TR19L_HUMAN

Tumor necrosis factor receptor superfamily member 19L

0.361

CAHM1_HUMAN

Calcium homeostasis modulator protein 1

0.361

EDAR_HUMAN

Tumor necrosis factor receptor superfamily member EDAR

0.361

UR2R_HUMAN

Urotensin-2 receptor

0.361

MFR1L_HUMAN

Mitochondrial fission regulator 1-like

0.361

GPR26_HUMAN

G-protein coupled receptor 26

0.361

NKAP1_HUMAN

Uncharacterized protein NKAPD1

0.385

OPSX_HUMAN

Visual pigment-like receptor peropsin

0.385

APOB_HUMAN

Apolipoprotein B-100

0.392

ADRB1_HUMAN

Beta-1 adrenergic receptor

0.392

CEP63_HUMAN

Centrosomal protein of 63 kDa

0.392

SNP47_HUMAN

Synaptosomal-associated protein 47

0.392

FXL18_HUMAN

F-box/LRR-repeat protein 18

0.392

RAG1_HUMAN

V(D)J recombination-activating protein 1

0.392

KTBL1_HUMAN

KATNB1-like protein 1

0.400

COCA1_HUMAN

Collagen alpha-1(XII) chain

0.400

5HT6R_HUMAN

5-hydroxytryptamine receptor 6

0.400

MK06_HUMAN

Mitogen-activated protein kinase 6

0.400

ASB7_HUMAN

Ankyrin repeat and SOCS box protein 7

0.400

HNF1B_HUMAN

Hepatocyte nuclear factor 1-beta

0.400

WIPF1_HUMAN

WAS/WASL-interacting protein family member 1

0.400

PRR11_HUMAN

Proline-rich protein 11

0.400

F124B_HUMAN

Protein FAM124B

0.400

GPBL1_HUMAN

Vasculin-like protein 1

0.400

BCL10_HUMAN

B-cell lymphoma/leukemia 10

0.400

SLF2_HUMAN

SMC5-SMC6 complex localization factor protein 2

0.400

SIMC1_HUMAN

SUMO-interacting motif-containing protein 1

0.400

LYAM3_HUMAN

P-selectin

0.400

NCF4_HUMAN

Neutrophil cytosol factor 4

0.400

PJVK_HUMAN

Pejvakin

0.400

CTHR1_HUMAN

Collagen triple helix repeat-containing protein 1

0.400

TNIP1_HUMAN

TNFAIP3-interacting protein 1

0.400

BOREA_HUMAN

Borealin

0.400

SNX10_HUMAN

Sorting nexin-10

0.400

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

FBX41_HUMAN

F-box only protein 41

0.283

HRH2_HUMAN

Histamine H2 receptor

0.289

PEAK1_HUMAN

Inactive tyrosine-protein kinase PEAK1

0.289

FANCB_HUMAN

Fanconi anemia group B protein

0.289

FP100_HUMAN

Fanconi anemia core complex-associated protein 100

0.295

IL17F_HUMAN

Interleukin-17F

0.295

SHLD2_HUMAN

Shieldin complex subunit 2

0.295

SPICE_HUMAN

Spindle and centriole-associated protein 1

0.340

SFRP3_HUMAN

Secreted frizzled-related protein 3

0.346

NSMF_HUMAN

NMDA receptor synaptonuclear signaling and neuronal migration factor

0.346

PRSR1_HUMAN

Proline and serine-rich protein 1

0.354

PRAG1_HUMAN

Inactive tyrosine-protein kinase PRAG1

0.354

BEND3_HUMAN

BEN domain-containing protein 3

0.354

PIT1_HUMAN

Pituitary-specific positive transcription factor 1

0.354

TGFB2_HUMAN

Transforming growth factor beta-2 proprotein

0.354

HNMT_HUMAN

Histamine N-methyltransferase

0.354

PKR2_HUMAN

Prokineticin receptor 2

0.354

TM206_HUMAN

Transmembrane protein 206

0.361

SMI19_HUMAN

Small integral membrane protein 19

0.361

BEND7_HUMAN

BEN domain-containing protein 7

0.361

CJ088_HUMAN

Uncharacterized protein C10orf88

0.361

TR19L_HUMAN

Tumor necrosis factor receptor superfamily member 19L

0.361

CAHM1_HUMAN

Calcium homeostasis modulator protein 1

0.361

EDAR_HUMAN

Tumor necrosis factor receptor superfamily member EDAR

0.361

UR2R_HUMAN

Urotensin-2 receptor

0.361

MFR1L_HUMAN

Mitochondrial fission regulator 1-like

0.361

GPR26_HUMAN

G-protein coupled receptor 26

0.361

NKAP1_HUMAN

Uncharacterized protein NKAPD1

0.385

OPSX_HUMAN

Visual pigment-like receptor peropsin

0.385

APOB_HUMAN

Apolipoprotein B-100

0.392

ADRB1_HUMAN

Beta-1 adrenergic receptor

0.392

CEP63_HUMAN

Centrosomal protein of 63 kDa

0.392

SNP47_HUMAN

Synaptosomal-associated protein 47

0.392

FXL18_HUMAN

F-box/LRR-repeat protein 18

0.392

RAG1_HUMAN

V(D)J recombination-activating protein 1

0.392

KTBL1_HUMAN

KATNB1-like protein 1

0.400

COCA1_HUMAN

Collagen alpha-1(XII) chain

0.400

5HT6R_HUMAN

5-hydroxytryptamine receptor 6

0.400

MK06_HUMAN

Mitogen-activated protein kinase 6

0.400

ASB7_HUMAN

Ankyrin repeat and SOCS box protein 7

0.400

HNF1B_HUMAN

Hepatocyte nuclear factor 1-beta

0.400

WIPF1_HUMAN

WAS/WASL-interacting protein family member 1

0.400

PRR11_HUMAN

Proline-rich protein 11

0.400

F124B_HUMAN

Protein FAM124B

0.400

GPBL1_HUMAN

Vasculin-like protein 1

0.400

BCL10_HUMAN

B-cell lymphoma/leukemia 10

0.400

SLF2_HUMAN

SMC5-SMC6 complex localization factor protein 2

0.400

SIMC1_HUMAN

SUMO-interacting motif-containing protein 1

0.400

LYAM3_HUMAN

P-selectin

0.400

NCF4_HUMAN

Neutrophil cytosol factor 4

0.400

PJVK_HUMAN

Pejvakin

0.400

CTHR1_HUMAN

Collagen triple helix repeat-containing protein 1

0.400

TNIP1_HUMAN

TNFAIP3-interacting protein 1

0.400

BOREA_HUMAN

Borealin

0.400

SNX10_HUMAN

Sorting nexin-10

0.400

MID51_HUMAN

Mitochondrial dynamics protein MID51

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 23 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy