TBC21_HUMAN 2019

Gene Name TBC21

Description TBC1 domain family member 21

Length 336

9606

Sequence

>sp|Q8IYX1|TBC21_HUMAN TBC1 domain family member 21
MTTLSPENSLSARQSASFILVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNLIDLDADELISAACVVYAELIQKDVPQTLKDFFL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

PRS54_HUMAN

Inactive serine protease 54

0.000

CQ064_HUMAN

Uncharacterized protein C17orf64

0.000

HPIP_HUMAN

Host cell factor C1 regulator 1

0.000

AKAP4_HUMAN

A-kinase anchor protein 4

0.000

CC159_HUMAN

Coiled-coil domain-containing protein 159

0.000

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.000

NKG7_HUMAN

Protein NKG7

0.000

O6C74_HUMAN

Olfactory receptor 6C74

0.000

PRS53_HUMAN

Serine protease 53

0.000

OR6C1_HUMAN

Olfactory receptor 6C1

0.000

DMP1_HUMAN

Dentin matrix acidic phosphoprotein 1

0.000

ACTT2_HUMAN

Actin-related protein T2

0.000

ABEC1_HUMAN

C->U-editing enzyme APOBEC-1

0.000

SMRP1_HUMAN

Spermatid-specific manchette-related protein 1

0.000

TM139_HUMAN

Transmembrane protein 139

0.000

TACT_HUMAN

T-cell surface protein tactile

0.000

NPS_HUMAN

Neuropeptide S

0.302

VEXIN_HUMAN

Vexin

0.302

TM109_HUMAN

Transmembrane protein 109

0.302

MALL_HUMAN

MAL-like protein

0.302

CO062_HUMAN

Uncharacterized protein C15orf62, mitochondrial

0.302

IL9R_HUMAN

Interleukin-9 receptor

0.302

CBY3_HUMAN

Protein chibby homolog 3

0.302

K1C23_HUMAN

Keratin, type I cytoskeletal 23

0.302

MISSL_HUMAN

MAPK-interacting and spindle-stabilizing protein-like

0.302

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.302

SPERT_HUMAN

Spermatid-associated protein

0.302

CC185_HUMAN

Coiled-coil domain-containing protein 185

0.302

FYB2_HUMAN

FYN-binding protein 2

0.302

OSTP_HUMAN

Osteopontin

0.302

GKN2_HUMAN

Gastrokine-2

0.302

M4A15_HUMAN

Membrane-spanning 4-domains subfamily A member 15

0.302

GSDMA_HUMAN

Gasdermin-A

0.302

AKAP5_HUMAN

A-kinase anchor protein 5

0.302

CD5_HUMAN

T-cell surface glycoprotein CD5

0.302

CF132_HUMAN

Uncharacterized protein C6orf132

0.302

IL15_HUMAN

Interleukin-15

0.302

IL23R_HUMAN

Interleukin-23 receptor

0.302

ZPBP1_HUMAN

Zona pellucida-binding protein 1

0.302

MTCP1_HUMAN

Protein p13 MTCP-1

0.302

BASP1_HUMAN

Brain acid soluble protein 1

0.302

NFAM1_HUMAN

NFAT activation molecule 1

0.302

MROH7_HUMAN

Maestro heat-like repeat-containing protein family member 7

0.302

TB182_HUMAN

182 kDa tankyrase-1-binding protein

0.302

OR6C3_HUMAN

Olfactory receptor 6C3

0.316

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.316

OR1F1_HUMAN

Olfactory receptor 1F1

0.316

TM247_HUMAN

Transmembrane protein 247

0.316

AKAP3_HUMAN

A-kinase anchor protein 3

0.316

VSIG8_HUMAN

V-set and immunoglobulin domain-containing protein 8

0.316

OR1E2_HUMAN

Olfactory receptor 1E2

0.316

O2AP1_HUMAN

Olfactory receptor 2AP1

0.316

O11H6_HUMAN

Olfactory receptor 11H6

0.316

S10A9_HUMAN

Protein S100-A9

0.316

FAIM3_HUMAN

Fas apoptotic inhibitory molecule 3

0.316

OR6F1_HUMAN

Olfactory receptor 6F1

0.316

IQCF1_HUMAN

IQ domain-containing protein F1

0.316

O6C68_HUMAN

Olfactory receptor 6C68

0.316

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.316

O13A1_HUMAN

Olfactory receptor 13A1

0.316

ACTL9_HUMAN

Actin-like protein 9

0.316

OR1E1_HUMAN

Olfactory receptor 1E1

0.316

NIBL2_HUMAN

Niban-like protein 2

0.316

WFDC5_HUMAN

WAP four-disulfide core domain protein 5

0.316

O10D4_HUMAN

Putative olfactory receptor 10D4

0.316

M4A8_HUMAN

Membrane-spanning 4-domains subfamily A member 8

0.316

I36RA_HUMAN

Interleukin-36 receptor antagonist protein

0.316

OR6Y1_HUMAN

Olfactory receptor 6Y1

0.316

O13G1_HUMAN

Olfactory receptor 13G1

0.316

IL1RA_HUMAN

Interleukin-1 receptor antagonist protein

0.316

T4S19_HUMAN

Transmembrane 4 L6 family member 19

0.316

O11G2_HUMAN

Olfactory receptor 11G2

0.316

OR6C2_HUMAN

Olfactory receptor 6C2

0.316

I27RA_HUMAN

Interleukin-27 receptor subunit alpha

0.316

IQCF6_HUMAN

IQ domain-containing protein F6

0.316

LMTD2_HUMAN

Lamin tail domain-containing protein 2

0.316

CNPY1_HUMAN

Protein canopy homolog 1

0.316

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

PRS54_HUMAN

Inactive serine protease 54

0.000

CQ064_HUMAN

Uncharacterized protein C17orf64

0.000

HPIP_HUMAN

Host cell factor C1 regulator 1

0.000

AKAP4_HUMAN

A-kinase anchor protein 4

0.000

CC159_HUMAN

Coiled-coil domain-containing protein 159

0.000

ARM12_HUMAN

Armadillo repeat-containing protein 12

0.000

NKG7_HUMAN

Protein NKG7

0.000

O6C74_HUMAN

Olfactory receptor 6C74

0.000

PRS53_HUMAN

Serine protease 53

0.000

OR6C1_HUMAN

Olfactory receptor 6C1

0.000

DMP1_HUMAN

Dentin matrix acidic phosphoprotein 1

0.000

ACTT2_HUMAN

Actin-related protein T2

0.000

ABEC1_HUMAN

C->U-editing enzyme APOBEC-1

0.000

SMRP1_HUMAN

Spermatid-specific manchette-related protein 1

0.000

TM139_HUMAN

Transmembrane protein 139

0.000

TACT_HUMAN

T-cell surface protein tactile

0.000

NPS_HUMAN

Neuropeptide S

0.302

VEXIN_HUMAN

Vexin

0.302

TM109_HUMAN

Transmembrane protein 109

0.302

MALL_HUMAN

MAL-like protein

0.302

CO062_HUMAN

Uncharacterized protein C15orf62, mitochondrial

0.302

IL9R_HUMAN

Interleukin-9 receptor

0.302

CBY3_HUMAN

Protein chibby homolog 3

0.302

K1C23_HUMAN

Keratin, type I cytoskeletal 23

0.302

MISSL_HUMAN

MAPK-interacting and spindle-stabilizing protein-like

0.302

TNFL8_HUMAN

Tumor necrosis factor ligand superfamily member 8

0.302

SPERT_HUMAN

Spermatid-associated protein

0.302

CC185_HUMAN

Coiled-coil domain-containing protein 185

0.302

FYB2_HUMAN

FYN-binding protein 2

0.302

OSTP_HUMAN

Osteopontin

0.302

GKN2_HUMAN

Gastrokine-2

0.302

M4A15_HUMAN

Membrane-spanning 4-domains subfamily A member 15

0.302

GSDMA_HUMAN

Gasdermin-A

0.302

AKAP5_HUMAN

A-kinase anchor protein 5

0.302

CD5_HUMAN

T-cell surface glycoprotein CD5

0.302

CF132_HUMAN

Uncharacterized protein C6orf132

0.302

IL15_HUMAN

Interleukin-15

0.302

IL23R_HUMAN

Interleukin-23 receptor

0.302

ZPBP1_HUMAN

Zona pellucida-binding protein 1

0.302

MTCP1_HUMAN

Protein p13 MTCP-1

0.302

BASP1_HUMAN

Brain acid soluble protein 1

0.302

NFAM1_HUMAN

NFAT activation molecule 1

0.302

MROH7_HUMAN

Maestro heat-like repeat-containing protein family member 7

0.302

TB182_HUMAN

182 kDa tankyrase-1-binding protein

0.302

OR6C3_HUMAN

Olfactory receptor 6C3

0.316

FNDC8_HUMAN

Fibronectin type III domain-containing protein 8

0.316

OR1F1_HUMAN

Olfactory receptor 1F1

0.316

TM247_HUMAN

Transmembrane protein 247

0.316

AKAP3_HUMAN

A-kinase anchor protein 3

0.316

VSIG8_HUMAN

V-set and immunoglobulin domain-containing protein 8

0.316

OR1E2_HUMAN

Olfactory receptor 1E2

0.316

O2AP1_HUMAN

Olfactory receptor 2AP1

0.316

O11H6_HUMAN

Olfactory receptor 11H6

0.316

S10A9_HUMAN

Protein S100-A9

0.316

FAIM3_HUMAN

Fas apoptotic inhibitory molecule 3

0.316

OR6F1_HUMAN

Olfactory receptor 6F1

0.316

IQCF1_HUMAN

IQ domain-containing protein F1

0.316

O6C68_HUMAN

Olfactory receptor 6C68

0.316

SPAT9_HUMAN

Spermatogenesis-associated protein 9

0.316

O13A1_HUMAN

Olfactory receptor 13A1

0.316

ACTL9_HUMAN

Actin-like protein 9

0.316

OR1E1_HUMAN

Olfactory receptor 1E1

0.316

NIBL2_HUMAN

Niban-like protein 2

0.316

WFDC5_HUMAN

WAP four-disulfide core domain protein 5

0.316

O10D4_HUMAN

Putative olfactory receptor 10D4

0.316

M4A8_HUMAN

Membrane-spanning 4-domains subfamily A member 8

0.316

I36RA_HUMAN

Interleukin-36 receptor antagonist protein

0.316

OR6Y1_HUMAN

Olfactory receptor 6Y1

0.316

O13G1_HUMAN

Olfactory receptor 13G1

0.316

IL1RA_HUMAN

Interleukin-1 receptor antagonist protein

0.316

T4S19_HUMAN

Transmembrane 4 L6 family member 19

0.316

O11G2_HUMAN

Olfactory receptor 11G2

0.316

OR6C2_HUMAN

Olfactory receptor 6C2

0.316

I27RA_HUMAN

Interleukin-27 receptor subunit alpha

0.316

IQCF6_HUMAN

IQ domain-containing protein F6

0.316

LMTD2_HUMAN

Lamin tail domain-containing protein 2

0.316

CNPY1_HUMAN

Protein canopy homolog 1

0.316

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 10 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy