NTNG2_HUMAN 2019

Gene Name NTNG2

Description Netrin-G2

Length 530

9606

Sequence

>sp|Q96CW9|NTNG2_HUMAN Netrin-G2
MLHLLALFLHCLPLASGDYDICKSWVTTDEGPTWEFYACQPKVMRLKDYVKVKVEPSGITCGDPPERFCSHENPYLCSNECDASNPDLAHPPRLMFDKEEEGLATYWQSITWSRYPSPLEANITLSWNKTVELTDDVVMTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSSSSAHRVLCTEEYSRWAGSKKEKHVRFEVRDRFAIFAGPDLRNMDNLYTRLESAKGLKEFFTLTDLRMRLLRPALGGTYVQRENLYKYFYAISNIEVIGRCKCNLHANLCSMREGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPHGSPNACATAGSFGNCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCNETGFCECREGAAGPKCDDCLPTHYWRQGCYPNVCDDDQLLCQNGGTCLQNQRCACPRGYTGVRCEQPRCDPADDDGGLDCDRAPGAAPRPATLLGCLLLLGLAARLGR

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

MACC1_HUMAN

Metastasis-associated in colon cancer protein 1

0.309

ZBT34_HUMAN

Zinc finger and BTB domain-containing protein 34

0.309

SH3B4_HUMAN

SH3 domain-binding protein 4

0.309

ZBT37_HUMAN

Zinc finger and BTB domain-containing protein 37

0.309

STC1_HUMAN

Stanniocalcin-1

0.309

GTF2I_HUMAN

General transcription factor II-I

0.316

VWA2_HUMAN

von Willebrand factor A domain-containing protein 2

0.316

LFTY2_HUMAN

Left-right determination factor 2

0.369

S1PR1_HUMAN

Sphingosine 1-phosphate receptor 1

0.369

MASP1_HUMAN

Mannan-binding lectin serine protease 1

0.369

LPAR1_HUMAN

Lysophosphatidic acid receptor 1

0.369

T126A_HUMAN

Transmembrane protein 126A

0.369

DKK2_HUMAN

Dickkopf-related protein 2

0.369

LRC3B_HUMAN

Leucine-rich repeat-containing protein 3B

0.369

LFTY1_HUMAN

Left-right determination factor 1

0.369

CNMD_HUMAN

Leukocyte cell-derived chemotaxin 1

0.369

NET4_HUMAN

Netrin-4

0.369

STC2_HUMAN

Stanniocalcin-2

0.369

I17RA_HUMAN

Interleukin-17 receptor A

0.369

EDNRB_HUMAN

Endothelin receptor type B

0.378

LARGN_HUMAN

Protein Largen

0.378

HBAZ_HUMAN

Hemoglobin subunit zeta

0.378

IKZF4_HUMAN

Zinc finger protein Eos

0.378

ZHX2_HUMAN

Zinc fingers and homeoboxes protein 2

0.378

EDNRA_HUMAN

Endothelin-1 receptor

0.378

I10R2_HUMAN

Interleukin-10 receptor subunit beta

0.378

SLIK6_HUMAN

SLIT and NTRK-like protein 6

0.378

PGBD5_HUMAN

PiggyBac transposable element-derived protein 5

0.378

EFNA5_HUMAN

Ephrin-A5

0.378

HABP2_HUMAN

Hyaluronan-binding protein 2

0.378

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.378

TSN18_HUMAN

Tetraspanin-18

0.378

RAMP3_HUMAN

Receptor activity-modifying protein 3

0.378

STXB6_HUMAN

Syntaxin-binding protein 6

0.378

T255A_HUMAN

Transmembrane protein 255A

0.378

NTNG1_HUMAN

Netrin-G1

0.378

T150A_HUMAN

Transmembrane protein 150A

0.378

PTN_HUMAN

Pleiotrophin

0.378

ZN148_HUMAN

Zinc finger protein 148

0.378

GAK1B_HUMAN

Golgi-associated kinase 1B

0.378

RFXAP_HUMAN

Regulatory factor X-associated protein

0.378

SCG3_HUMAN

Secretogranin-3

0.378

CCDC3_HUMAN

Coiled-coil domain-containing protein 3

0.378

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.378

MUC18_HUMAN

Cell surface glycoprotein MUC18

0.378

TRIM1_HUMAN

Probable E3 ubiquitin-protein ligase MID2

0.378

DLK2_HUMAN

Protein delta homolog 2

0.378

ZN142_HUMAN

Zinc finger protein 142

0.378

CD166_HUMAN

CD166 antigen

0.378

PRLHR_HUMAN

Prolactin-releasing peptide receptor

0.378

PRLR_HUMAN

Prolactin receptor

0.378

EFCC1_HUMAN

EF-hand and coiled-coil domain-containing protein 1

0.378

RLF_HUMAN

Zinc finger protein Rlf

0.378

C2C4C_HUMAN

C2 calcium-dependent domain-containing protein 4C

0.378

EURL_HUMAN

Protein EURL homolog

0.378

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.378

CALD1_HUMAN

Caldesmon

0.378

AKAP2_HUMAN

A-kinase anchor protein 2

0.378

GT2D1_HUMAN

General transcription factor II-I repeat domain-containing protein 1

0.378

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.378

FLIP1_HUMAN

Filamin-A-interacting protein 1

0.378

FBLN7_HUMAN

Fibulin-7

0.378

GPC5B_HUMAN

G-protein coupled receptor family C group 5 member B

0.378

TPA_HUMAN

Tissue-type plasminogen activator

0.378

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.378

BORG2_HUMAN

Cdc42 effector protein 3

0.378

CRBA1_HUMAN

Beta-crystallin A3

0.378

PKHO2_HUMAN

Pleckstrin homology domain-containing family O member 2

0.387

TPRN_HUMAN

Taperin

0.387

F131B_HUMAN

Protein FAM131B

0.387

SCN3B_HUMAN

Sodium channel subunit beta-3

0.387

ZHX3_HUMAN

Zinc fingers and homeoboxes protein 3

0.387

HIC1_HUMAN

Hypermethylated in cancer 1 protein

0.387

ZBT22_HUMAN

Zinc finger and BTB domain-containing protein 22

0.387

LRRN4_HUMAN

Leucine-rich repeat neuronal protein 4

0.387

TZAP_HUMAN

Telomere zinc finger-associated protein

0.387

K1107_HUMAN

AP2-interacting clathrin-endocytosis protein

0.387

ICAL_HUMAN

Calpastatin

0.387

P2Y10_HUMAN

Putative P2Y purinoceptor 10

0.387

PR15L_HUMAN

Proline-rich protein 15-like protein

0.387

IL3RB_HUMAN

Cytokine receptor common subunit beta

0.387

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

MACC1_HUMAN

Metastasis-associated in colon cancer protein 1

0.309

ZBT34_HUMAN

Zinc finger and BTB domain-containing protein 34

0.309

SH3B4_HUMAN

SH3 domain-binding protein 4

0.309

ZBT37_HUMAN

Zinc finger and BTB domain-containing protein 37

0.309

STC1_HUMAN

Stanniocalcin-1

0.309

GTF2I_HUMAN

General transcription factor II-I

0.316

VWA2_HUMAN

von Willebrand factor A domain-containing protein 2

0.316

LFTY2_HUMAN

Left-right determination factor 2

0.369

S1PR1_HUMAN

Sphingosine 1-phosphate receptor 1

0.369

MASP1_HUMAN

Mannan-binding lectin serine protease 1

0.369

LPAR1_HUMAN

Lysophosphatidic acid receptor 1

0.369

T126A_HUMAN

Transmembrane protein 126A

0.369

DKK2_HUMAN

Dickkopf-related protein 2

0.369

LRC3B_HUMAN

Leucine-rich repeat-containing protein 3B

0.369

LFTY1_HUMAN

Left-right determination factor 1

0.369

CNMD_HUMAN

Leukocyte cell-derived chemotaxin 1

0.369

NET4_HUMAN

Netrin-4

0.369

STC2_HUMAN

Stanniocalcin-2

0.369

I17RA_HUMAN

Interleukin-17 receptor A

0.369

EDNRB_HUMAN

Endothelin receptor type B

0.378

LARGN_HUMAN

Protein Largen

0.378

HBAZ_HUMAN

Hemoglobin subunit zeta

0.378

IKZF4_HUMAN

Zinc finger protein Eos

0.378

ZHX2_HUMAN

Zinc fingers and homeoboxes protein 2

0.378

EDNRA_HUMAN

Endothelin-1 receptor

0.378

I10R2_HUMAN

Interleukin-10 receptor subunit beta

0.378

SLIK6_HUMAN

SLIT and NTRK-like protein 6

0.378

PGBD5_HUMAN

PiggyBac transposable element-derived protein 5

0.378

EFNA5_HUMAN

Ephrin-A5

0.378

HABP2_HUMAN

Hyaluronan-binding protein 2

0.378

ZBT10_HUMAN

Zinc finger and BTB domain-containing protein 10

0.378

TSN18_HUMAN

Tetraspanin-18

0.378

RAMP3_HUMAN

Receptor activity-modifying protein 3

0.378

STXB6_HUMAN

Syntaxin-binding protein 6

0.378

T255A_HUMAN

Transmembrane protein 255A

0.378

NTNG1_HUMAN

Netrin-G1

0.378

T150A_HUMAN

Transmembrane protein 150A

0.378

PTN_HUMAN

Pleiotrophin

0.378

ZN148_HUMAN

Zinc finger protein 148

0.378

GAK1B_HUMAN

Golgi-associated kinase 1B

0.378

RFXAP_HUMAN

Regulatory factor X-associated protein

0.378

SCG3_HUMAN

Secretogranin-3

0.378

CCDC3_HUMAN

Coiled-coil domain-containing protein 3

0.378

LGI2_HUMAN

Leucine-rich repeat LGI family member 2

0.378

MUC18_HUMAN

Cell surface glycoprotein MUC18

0.378

TRIM1_HUMAN

Probable E3 ubiquitin-protein ligase MID2

0.378

DLK2_HUMAN

Protein delta homolog 2

0.378

ZN142_HUMAN

Zinc finger protein 142

0.378

CD166_HUMAN

CD166 antigen

0.378

PRLHR_HUMAN

Prolactin-releasing peptide receptor

0.378

PRLR_HUMAN

Prolactin receptor

0.378

EFCC1_HUMAN

EF-hand and coiled-coil domain-containing protein 1

0.378

RLF_HUMAN

Zinc finger protein Rlf

0.378

C2C4C_HUMAN

C2 calcium-dependent domain-containing protein 4C

0.378

EURL_HUMAN

Protein EURL homolog

0.378

LGI1_HUMAN

Leucine-rich glioma-inactivated protein 1

0.378

CALD1_HUMAN

Caldesmon

0.378

AKAP2_HUMAN

A-kinase anchor protein 2

0.378

GT2D1_HUMAN

General transcription factor II-I repeat domain-containing protein 1

0.378

LRAD3_HUMAN

Low-density lipoprotein receptor class A domain-containing protein 3

0.378

FLIP1_HUMAN

Filamin-A-interacting protein 1

0.378

FBLN7_HUMAN

Fibulin-7

0.378

GPC5B_HUMAN

G-protein coupled receptor family C group 5 member B

0.378

TPA_HUMAN

Tissue-type plasminogen activator

0.378

PCLI1_HUMAN

PTB-containing, cubilin and LRP1-interacting protein

0.378

BORG2_HUMAN

Cdc42 effector protein 3

0.378

CRBA1_HUMAN

Beta-crystallin A3

0.378

PKHO2_HUMAN

Pleckstrin homology domain-containing family O member 2

0.387

TPRN_HUMAN

Taperin

0.387

F131B_HUMAN

Protein FAM131B

0.387

SCN3B_HUMAN

Sodium channel subunit beta-3

0.387

ZHX3_HUMAN

Zinc fingers and homeoboxes protein 3

0.387

HIC1_HUMAN

Hypermethylated in cancer 1 protein

0.387

ZBT22_HUMAN

Zinc finger and BTB domain-containing protein 22

0.387

LRRN4_HUMAN

Leucine-rich repeat neuronal protein 4

0.387

TZAP_HUMAN

Telomere zinc finger-associated protein

0.387

K1107_HUMAN

AP2-interacting clathrin-endocytosis protein

0.387

ICAL_HUMAN

Calpastatin

0.387

P2Y10_HUMAN

Putative P2Y purinoceptor 10

0.387

PR15L_HUMAN

Proline-rich protein 15-like protein

0.387

IL3RB_HUMAN

Cytokine receptor common subunit beta

0.387

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 19 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy