MTA3_HUMAN 2019

Gene Name MTA3

Description Metastasis-associated protein MTA3

Length 594

9606

Sequence

>sp|Q9BTC8|MTA3_HUMAN Metastasis-associated protein MTA3
MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYSKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGYLEIHPAKKPNVIRSTPSLQTPTTKRMLTTPNHTSLSILGKRNYSHHNGLDELTCCVSD

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.340

FERM2_HUMAN

Fermitin family homolog 2

0.340

FERM1_HUMAN

Fermitin family homolog 1

0.340

NEB2_HUMAN

Neurabin-2

0.343

WNT5A_HUMAN

Protein Wnt-5a

0.343

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.343

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.343

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.363

SNX6_HUMAN

Sorting nexin-6

0.363

MTA1_HUMAN

Metastasis-associated protein MTA1

0.363

TGFR1_HUMAN

TGF-beta receptor type-1

0.367

WLS_HUMAN

Protein wntless homolog

0.367

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.367

BMP2_HUMAN

Bone morphogenetic protein 2

0.367

RIMB2_HUMAN

RIMS-binding protein 2

0.367

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.370

BMP5_HUMAN

Bone morphogenetic protein 5

0.370

COE1_HUMAN

Transcription factor COE1

0.370

VANG1_HUMAN

Vang-like protein 1

0.370

CPEB2_HUMAN

Cytoplasmic polyadenylation element-binding protein 2

0.370

TPD54_HUMAN

Tumor protein D54

0.374

PAR6A_HUMAN

Partitioning defective 6 homolog alpha

0.374

SMAD5_HUMAN

Mothers against decapentaplegic homolog 5

0.378

STIM2_HUMAN

Stromal interaction molecule 2

0.385

MTA2_HUMAN

Metastasis-associated protein MTA2

0.385

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.385

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.385

ARFP1_HUMAN

Arfaptin-1

0.385

STIM1_HUMAN

Stromal interaction molecule 1

0.385

AFAD_HUMAN

Afadin

0.385

PLXA2_HUMAN

Plexin-A2

0.389

RUNX2_HUMAN

Runt-related transcription factor 2

0.389

FGFR1_HUMAN

Fibroblast growth factor receptor 1

0.389

FGFR2_HUMAN

Fibroblast growth factor receptor 2

0.389

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.389

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.389

ANKY2_HUMAN

Ankyrin repeat and MYND domain-containing protein 2

0.389

BAF_HUMAN

Barrier-to-autointegration factor

0.389

MIGA1_HUMAN

Mitoguardin 1

0.389

SYT1_HUMAN

Synaptotagmin-1

0.389

ARFP2_HUMAN

Arfaptin-2

0.389

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.392

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.392

JPH1_HUMAN

Junctophilin-1

0.392

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.392

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.392

HTF4_HUMAN

Transcription factor 12

0.392

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.392

CPEB4_HUMAN

Cytoplasmic polyadenylation element-binding protein 4

0.392

BMP4_HUMAN

Bone morphogenetic protein 4

0.392

BMP7_HUMAN

Bone morphogenetic protein 7

0.392

RUND1_HUMAN

RUN domain-containing protein 1

0.392

AT1B4_HUMAN

Protein ATP1B4

0.392

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.392

E41L1_HUMAN

Band 4.1-like protein 1

0.396

NFIC_HUMAN

Nuclear factor 1 C-type

0.396

LIN7C_HUMAN

Protein lin-7 homolog C

0.396

NFIX_HUMAN

Nuclear factor 1 X-type

0.400

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RGAP1_HUMAN

Rac GTPase-activating protein 1

0.340

FERM2_HUMAN

Fermitin family homolog 2

0.340

FERM1_HUMAN

Fermitin family homolog 1

0.340

NEB2_HUMAN

Neurabin-2

0.343

WNT5A_HUMAN

Protein Wnt-5a

0.343

SMAD1_HUMAN

Mothers against decapentaplegic homolog 1

0.343

CPEB1_HUMAN

Cytoplasmic polyadenylation element-binding protein 1

0.343

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.363

SNX6_HUMAN

Sorting nexin-6

0.363

MTA1_HUMAN

Metastasis-associated protein MTA1

0.363

TGFR1_HUMAN

TGF-beta receptor type-1

0.367

WLS_HUMAN

Protein wntless homolog

0.367

CPEB3_HUMAN

Cytoplasmic polyadenylation element-binding protein 3

0.367

BMP2_HUMAN

Bone morphogenetic protein 2

0.367

RIMB2_HUMAN

RIMS-binding protein 2

0.367

SMAD9_HUMAN

Mothers against decapentaplegic homolog 9

0.370

BMP5_HUMAN

Bone morphogenetic protein 5

0.370

COE1_HUMAN

Transcription factor COE1

0.370

VANG1_HUMAN

Vang-like protein 1

0.370

CPEB2_HUMAN

Cytoplasmic polyadenylation element-binding protein 2

0.370

TPD54_HUMAN

Tumor protein D54

0.374

PAR6A_HUMAN

Partitioning defective 6 homolog alpha

0.374

SMAD5_HUMAN

Mothers against decapentaplegic homolog 5

0.378

STIM2_HUMAN

Stromal interaction molecule 2

0.385

MTA2_HUMAN

Metastasis-associated protein MTA2

0.385

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.385

OPA1_HUMAN

Dynamin-like 120 kDa protein, mitochondrial

0.385

ARFP1_HUMAN

Arfaptin-1

0.385

STIM1_HUMAN

Stromal interaction molecule 1

0.385

AFAD_HUMAN

Afadin

0.385

PLXA2_HUMAN

Plexin-A2

0.389

RUNX2_HUMAN

Runt-related transcription factor 2

0.389

FGFR1_HUMAN

Fibroblast growth factor receptor 1

0.389

FGFR2_HUMAN

Fibroblast growth factor receptor 2

0.389

VRK1_HUMAN

Serine/threonine-protein kinase VRK1

0.389

TRAM1_HUMAN

Translocating chain-associated membrane protein 1

0.389

ANKY2_HUMAN

Ankyrin repeat and MYND domain-containing protein 2

0.389

BAF_HUMAN

Barrier-to-autointegration factor

0.389

MIGA1_HUMAN

Mitoguardin 1

0.389

SYT1_HUMAN

Synaptotagmin-1

0.389

ARFP2_HUMAN

Arfaptin-2

0.389

JIP4_HUMAN

C-Jun-amino-terminal kinase-interacting protein 4

0.392

P85A_HUMAN

Phosphatidylinositol 3-kinase regulatory subunit alpha

0.392

JPH1_HUMAN

Junctophilin-1

0.392

TRAM2_HUMAN

Translocating chain-associated membrane protein 2

0.392

JIP3_HUMAN

C-Jun-amino-terminal kinase-interacting protein 3

0.392

HTF4_HUMAN

Transcription factor 12

0.392

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.392

CPEB4_HUMAN

Cytoplasmic polyadenylation element-binding protein 4

0.392

BMP4_HUMAN

Bone morphogenetic protein 4

0.392

BMP7_HUMAN

Bone morphogenetic protein 7

0.392

RUND1_HUMAN

RUN domain-containing protein 1

0.392

AT1B4_HUMAN

Protein ATP1B4

0.392

AT1B1_HUMAN

Sodium/potassium-transporting ATPase subunit beta-1

0.392

E41L1_HUMAN

Band 4.1-like protein 1

0.396

NFIC_HUMAN

Nuclear factor 1 C-type

0.396

LIN7C_HUMAN

Protein lin-7 homolog C

0.396

NFIX_HUMAN

Nuclear factor 1 X-type

0.400

AKAP1_HUMAN

A-kinase anchor protein 1, mitochondrial

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 49 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy