AMNLS_HUMAN 2019

Gene Name AMNLS

Description Protein amnionless

Length 453

9606

Sequence

>sp|Q9BXJ7|AMNLS_HUMAN Protein amnionless
MGVLGRVLLWLQLCALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDMLLPLDGELVLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSISALGRTFTRDEDLAVFLASRAGRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACHSALRPQGQCCDLCGAVVLLTHGPAFDLERYRARILDTFLGLPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMRESGAHVWGSSAAGLAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPVFDVTASEELPLPRRLSLVPKAAADSTSHSYFVNPLFAGAEAEA

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

NINJ1_HUMAN

Ninjurin-1

0.232

OSER1_HUMAN

Oxidative stress-responsive serine-rich protein 1

0.285

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.316

ELL2_HUMAN

RNA polymerase II elongation factor ELL2

0.320

NEUL2_HUMAN

Neuralized-like protein 2

0.320

MED29_HUMAN

Mediator of RNA polymerase II transcription subunit 29

0.324

USH1C_HUMAN

Harmonin

0.324

STRAA_HUMAN

STE20-related kinase adapter protein alpha

0.349

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.349

NRF1_HUMAN

Nuclear respiratory factor 1

0.349

CG026_HUMAN

Uncharacterized protein C7orf26

0.354

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.354

LMBL1_HUMAN

Lethal(3)malignant brain tumor-like protein 1

0.354

SMO_HUMAN

Smoothened homolog

0.354

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.358

RASF2_HUMAN

Ras association domain-containing protein 2

0.358

SSR2_HUMAN

Somatostatin receptor type 2

0.358

CHST3_HUMAN

Carbohydrate sulfotransferase 3

0.358

CP110_HUMAN

Centriolar coiled-coil protein of 110 kDa

0.358

RHG19_HUMAN

Rho GTPase-activating protein 19

0.358

CHRD_HUMAN

Chordin

0.358

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.363

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.363

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.363

STRAB_HUMAN

STE20-related kinase adapter protein beta

0.363

UBL7_HUMAN

Ubiquitin-like protein 7

0.363

ZN503_HUMAN

Zinc finger protein 503

0.363

NOL11_HUMAN

Nucleolar protein 11

0.363

ST14_HUMAN

Suppressor of tumorigenicity 14 protein

0.368

FJX1_HUMAN

Four-jointed box protein 1

0.368

LIX1L_HUMAN

LIX1-like protein

0.373

TSHR_HUMAN

Thyrotropin receptor

0.378

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.378

MAFK_HUMAN

Transcription factor MafK

0.378

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.378

ZN704_HUMAN

Zinc finger protein 704

0.378

FRPD4_HUMAN

FERM and PDZ domain-containing protein 4

0.383

CC85A_HUMAN

Coiled-coil domain-containing protein 85A

0.383

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.383

LMBL3_HUMAN

Lethal(3)malignant brain tumor-like protein 3

0.383

MED16_HUMAN

Mediator of RNA polymerase II transcription subunit 16

0.383

OTOP1_HUMAN

Proton channel OTOP1

0.383

RXFP1_HUMAN

Relaxin receptor 1

0.387

AIMP2_HUMAN

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

0.387

OPN4_HUMAN

Melanopsin

0.387

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.387

SPIR2_HUMAN

Protein spire homolog 2

0.387

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.387

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.387

USH1G_HUMAN

Usher syndrome type-1G protein

0.387

GXLT2_HUMAN

Glucoside xylosyltransferase 2

0.387

WHRN_HUMAN

Whirlin

0.387

DCA15_HUMAN

DDB1- and CUL4-associated factor 15

0.392

T179A_HUMAN

Transmembrane protein 179

0.392

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.392

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.392

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.392

CDR2L_HUMAN

Cerebellar degeneration-related protein 2-like

0.392

BOD1_HUMAN

Biorientation of chromosomes in cell division protein 1

0.392

RASF6_HUMAN

Ras association domain-containing protein 6

0.392

BD1L1_HUMAN

Biorientation of chromosomes in cell division protein 1-like 1

0.392

BAIP2_HUMAN

Brain-specific angiogenesis inhibitor 1-associated protein 2

0.392

GPS2_HUMAN

G protein pathway suppressor 2

0.392

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.392

SHRM2_HUMAN

Protein Shroom2

0.392

PRDM8_HUMAN

PR domain zinc finger protein 8

0.397

VGLL4_HUMAN

Transcription cofactor vestigial-like protein 4

0.397

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.397

IL16_HUMAN

Pro-interleukin-16

0.397

CHST6_HUMAN

Carbohydrate sulfotransferase 6

0.397

TAB2_HUMAN

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NINJ1_HUMAN

Ninjurin-1

0.232

OSER1_HUMAN

Oxidative stress-responsive serine-rich protein 1

0.285

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.316

ELL2_HUMAN

RNA polymerase II elongation factor ELL2

0.320

NEUL2_HUMAN

Neuralized-like protein 2

0.320

MED29_HUMAN

Mediator of RNA polymerase II transcription subunit 29

0.324

USH1C_HUMAN

Harmonin

0.324

STRAA_HUMAN

STE20-related kinase adapter protein alpha

0.349

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.349

NRF1_HUMAN

Nuclear respiratory factor 1

0.349

CG026_HUMAN

Uncharacterized protein C7orf26

0.354

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.354

LMBL1_HUMAN

Lethal(3)malignant brain tumor-like protein 1

0.354

SMO_HUMAN

Smoothened homolog

0.354

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.358

RASF2_HUMAN

Ras association domain-containing protein 2

0.358

SSR2_HUMAN

Somatostatin receptor type 2

0.358

CHST3_HUMAN

Carbohydrate sulfotransferase 3

0.358

CP110_HUMAN

Centriolar coiled-coil protein of 110 kDa

0.358

RHG19_HUMAN

Rho GTPase-activating protein 19

0.358

CHRD_HUMAN

Chordin

0.358

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.363

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.363

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.363

STRAB_HUMAN

STE20-related kinase adapter protein beta

0.363

UBL7_HUMAN

Ubiquitin-like protein 7

0.363

ZN503_HUMAN

Zinc finger protein 503

0.363

NOL11_HUMAN

Nucleolar protein 11

0.363

ST14_HUMAN

Suppressor of tumorigenicity 14 protein

0.368

FJX1_HUMAN

Four-jointed box protein 1

0.368

LIX1L_HUMAN

LIX1-like protein

0.373

TSHR_HUMAN

Thyrotropin receptor

0.378

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.378

MAFK_HUMAN

Transcription factor MafK

0.378

TXD11_HUMAN

Thioredoxin domain-containing protein 11

0.378

ZN704_HUMAN

Zinc finger protein 704

0.378

FRPD4_HUMAN

FERM and PDZ domain-containing protein 4

0.383

CC85A_HUMAN

Coiled-coil domain-containing protein 85A

0.383

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.383

LMBL3_HUMAN

Lethal(3)malignant brain tumor-like protein 3

0.383

MED16_HUMAN

Mediator of RNA polymerase II transcription subunit 16

0.383

OTOP1_HUMAN

Proton channel OTOP1

0.383

RXFP1_HUMAN

Relaxin receptor 1

0.387

AIMP2_HUMAN

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

0.387

OPN4_HUMAN

Melanopsin

0.387

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.387

SPIR2_HUMAN

Protein spire homolog 2

0.387

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.387

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.387

USH1G_HUMAN

Usher syndrome type-1G protein

0.387

GXLT2_HUMAN

Glucoside xylosyltransferase 2

0.387

WHRN_HUMAN

Whirlin

0.387

DCA15_HUMAN

DDB1- and CUL4-associated factor 15

0.392

T179A_HUMAN

Transmembrane protein 179

0.392

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.392

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.392

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.392

CDR2L_HUMAN

Cerebellar degeneration-related protein 2-like

0.392

BOD1_HUMAN

Biorientation of chromosomes in cell division protein 1

0.392

RASF6_HUMAN

Ras association domain-containing protein 6

0.392

BD1L1_HUMAN

Biorientation of chromosomes in cell division protein 1-like 1

0.392

BAIP2_HUMAN

Brain-specific angiogenesis inhibitor 1-associated protein 2

0.392

GPS2_HUMAN

G protein pathway suppressor 2

0.392

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.392

SHRM2_HUMAN

Protein Shroom2

0.392

PRDM8_HUMAN

PR domain zinc finger protein 8

0.397

VGLL4_HUMAN

Transcription cofactor vestigial-like protein 4

0.397

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.397

IL16_HUMAN

Pro-interleukin-16

0.397

CHST6_HUMAN

Carbohydrate sulfotransferase 6

0.397

TAB2_HUMAN

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

0.397

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 36 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy