PEX13_HUMAN 2019

Gene Name PEX13

Description Peroxisomal membrane protein PEX13

Length 403

9606

Sequence

>sp|Q92968|PEX13_HUMAN Peroxisomal membrane protein PEX13
MASQPPPPPKPWETRRIPGAGPGPGPGPTFQSADLGPTLMTRPGQPALTRVPPPILPRPSQQTGSSSVNTFRPAYSSFSSGYGAYGNSFYGGYSPYSYGYNGLGYNRLRVDDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQRMLGLRRGSENEDLWAESEGTVACLGAEDRAATSAKSWPIFLFFAVILGGPYLIWKLLSTHSDEVTDSINWASGEDDHVVARAEYDFAAVSEEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGKRKGRKTVESSKVSKQQQSFTNPTLTKGATVADSLDEQEAAFESVFVETNKVPVAPDSIGKDGEKQDL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.315

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.319

GOLP3_HUMAN

Golgi phosphoprotein 3

0.322

SURF4_HUMAN

Surfeit locus protein 4

0.326

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.327

VIGLN_HUMAN

Vigilin

0.327

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.334

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.335

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.336

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.338

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.341

DPP4_HUMAN

Dipeptidyl peptidase 4

0.341

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.342

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.342

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.346

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.349

SEPR_HUMAN

Prolyl endopeptidase FAP

0.349

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.349

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.350

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.350

GDE_HUMAN

Glycogen debranching enzyme

0.350

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.351

HIP1_HUMAN

Huntingtin-interacting protein 1

0.351

CACP_HUMAN

Carnitine O-acetyltransferase

0.352

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.354

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.354

S39A9_HUMAN

Zinc transporter ZIP9

0.355

SOS1_HUMAN

Son of sevenless homolog 1

0.356

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.356

GATA4_HUMAN

Transcription factor GATA-4

0.358

CUL1_HUMAN

Cullin-1

0.359

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.360

PBDC1_HUMAN

Protein PBDC1

0.361

SEPT7_HUMAN

Septin-7

0.362

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.363

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.363

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.364

RHOA_HUMAN

Transforming protein RhoA

0.364

STRP1_HUMAN

Striatin-interacting protein 1

0.364

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.365

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.365

ZNT1_HUMAN

Zinc transporter 1

0.366

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.366

M3K4_HUMAN

Mitogen-activated protein kinase kinase kinase 4

0.367

S2536_HUMAN

Solute carrier family 25 member 36

0.368

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.369

MTAP_HUMAN

S-methyl-5-thioadenosine phosphorylase

0.370

SRF_HUMAN

Serum response factor

0.371

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.371

SNX12_HUMAN

Sorting nexin-12

0.371

SUPT3_HUMAN

Transcription initiation protein SPT3 homolog

0.371

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.373

NPRL2_HUMAN

GATOR complex protein NPRL2

0.373

SOS2_HUMAN

Son of sevenless homolog 2

0.374

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.374

ERGI2_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 2

0.375

SNX3_HUMAN

Sorting nexin-3

0.376

POMT2_HUMAN

Protein O-mannosyl-transferase 2

0.377

YLAT2_HUMAN

Y+L amino acid transporter 2

0.378

DYR_HUMAN

Dihydrofolate reductase

0.378

GATA6_HUMAN

Transcription factor GATA-6

0.378

DBNL_HUMAN

Drebrin-like protein

0.381

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.382

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.382

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.383

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.384

TSC2_HUMAN

Tuberin

0.384

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.384

PAXI_HUMAN

Paxillin

0.385

BAT1_HUMAN

b(0,+)-type amino acid transporter 1

0.385

DOCK2_HUMAN

Dedicator of cytokinesis protein 2

0.385

DOCK1_HUMAN

Dedicator of cytokinesis protein 1

0.385

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.385

CEGT_HUMAN

Ceramide glucosyltransferase

0.385

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.386

MK14_HUMAN

Mitogen-activated protein kinase 14

0.386

PB1_HUMAN

Protein polybromo-1

0.386

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.386

STAM1_HUMAN

Signal transducing adapter molecule 1

0.387

DOP1_HUMAN

Protein dopey-1

0.388

S2533_HUMAN

Solute carrier family 25 member 33

0.388

CLAT_HUMAN

Choline O-acetyltransferase

0.389

HYAS3_HUMAN

Hyaluronan synthase 3

0.389

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.390

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.391

RHOC_HUMAN

Rho-related GTP-binding protein RhoC

0.391

MOT12_HUMAN

Monocarboxylate transporter 12

0.391

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.391

DOCK4_HUMAN

Dedicator of cytokinesis protein 4

0.392

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.393

K1109_HUMAN

Transmembrane protein KIAA1109

0.393

STAM2_HUMAN

Signal transducing adapter molecule 2

0.393

COR1C_HUMAN

Coronin-1C

0.394

STRP2_HUMAN

Striatin-interacting protein 2

0.395

DOP2_HUMAN

Protein dopey-2

0.395

YLAT1_HUMAN

Y+L amino acid transporter 1

0.396

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.396

KMT5B_HUMAN

Histone-lysine N-methyltransferase KMT5B

0.396

PLPL6_HUMAN

Neuropathy target esterase

0.396

EP15R_HUMAN

Epidermal growth factor receptor substrate 15-like 1

0.397

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.397

GATA5_HUMAN

Transcription factor GATA-5

0.397

GATA2_HUMAN

Endothelial transcription factor GATA-2

0.397

H33_HUMAN

Histone H3.3

0.398

UB2G2_HUMAN

Ubiquitin-conjugating enzyme E2 G2

0.398

RBNS5_HUMAN

Rabenosyn-5

0.398

RCC1_HUMAN

Regulator of chromosome condensation

0.398

C560_HUMAN

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

0.398

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.399

ARGI2_HUMAN

Arginase-2, mitochondrial

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 77 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy