PLK1_HUMAN 2019

Gene Name PLK1

Description Serine/threonine-protein kinase PLK1

Length 603

9606

Sequence

>sp|P53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.318

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.318

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.319

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.327

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.329

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.335

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.335

H33_HUMAN

Histone H3.3

0.335

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.338

RCC1_HUMAN

Regulator of chromosome condensation

0.343

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.345

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.345

SOS1_HUMAN

Son of sevenless homolog 1

0.346

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.346

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.347

NPRL2_HUMAN

GATOR complex protein NPRL2

0.347

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.347

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.351

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.352

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.352

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.353

S2536_HUMAN

Solute carrier family 25 member 36

0.355

CUL1_HUMAN

Cullin-1

0.355

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.356

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.356

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.356

PLK3_HUMAN

Serine/threonine-protein kinase PLK3

0.358

DCPS_HUMAN

m7GpppX diphosphatase

0.358

MPIP1_HUMAN

M-phase inducer phosphatase 1

0.359

VIGLN_HUMAN

Vigilin

0.359

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.359

S2533_HUMAN

Solute carrier family 25 member 33

0.360

COR1C_HUMAN

Coronin-1C

0.360

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.361

PLPL6_HUMAN

Neuropathy target esterase

0.362

CPSF4_HUMAN

Cleavage and polyadenylation specificity factor subunit 4

0.363

GORS2_HUMAN

Golgi reassembly-stacking protein 2

0.363

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.364

SEPT7_HUMAN

Septin-7

0.365

CC14A_HUMAN

Dual specificity protein phosphatase CDC14A

0.365

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.366

SOS2_HUMAN

Son of sevenless homolog 2

0.366

STRP1_HUMAN

Striatin-interacting protein 1

0.367

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.367

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.367

TBC20_HUMAN

TBC1 domain family member 20

0.368

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.368

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.368

RHOA_HUMAN

Transforming protein RhoA

0.370

RMND1_HUMAN

Required for meiotic nuclear division protein 1 homolog

0.370

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.371

PP2BB_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

0.371

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.371

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.371

RRAGB_HUMAN

Ras-related GTP-binding protein B

0.371

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.373

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.374

RABX5_HUMAN

Rab5 GDP/GTP exchange factor

0.374

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.376

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.377

TMED4_HUMAN

Transmembrane emp24 domain-containing protein 4

0.378

TMED9_HUMAN

Transmembrane emp24 domain-containing protein 9

0.378

DOP1_HUMAN

Protein dopey-1

0.378

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.378

GOLP3_HUMAN

Golgi phosphoprotein 3

0.379

ARGI2_HUMAN

Arginase-2, mitochondrial

0.380

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.381

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.381

ATP9B_HUMAN

Probable phospholipid-transporting ATPase IIB

0.382

UB2G2_HUMAN

Ubiquitin-conjugating enzyme E2 G2

0.382

CORO6_HUMAN

Coronin-6

0.383

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.384

CCHL_HUMAN

Cytochrome c-type heme lyase

0.384

SRF_HUMAN

Serum response factor

0.385

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.385

HID1_HUMAN

Protein HID1

0.386

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.386

ZNT1_HUMAN

Zinc transporter 1

0.386

MPIP2_HUMAN

M-phase inducer phosphatase 2

0.387

SNX12_HUMAN

Sorting nexin-12

0.388

CTDS1_HUMAN

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

0.389

RHOC_HUMAN

Rho-related GTP-binding protein RhoC

0.389

ARMT1_HUMAN

Protein-glutamate O-methyltransferase

0.389

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.390

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.390

CTDSL_HUMAN

CTD small phosphatase-like protein

0.390

GDE_HUMAN

Glycogen debranching enzyme

0.390

C560_HUMAN

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

0.391

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.391

GATA4_HUMAN

Transcription factor GATA-4

0.391

SURF4_HUMAN

Surfeit locus protein 4

0.392

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.392

SIR2_HUMAN

NAD-dependent protein deacetylase sirtuin-2

0.392

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.393

RDHE2_HUMAN

Epidermal retinol dehydrogenase 2

0.393

STRP2_HUMAN

Striatin-interacting protein 2

0.393

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.393

DOP2_HUMAN

Protein dopey-2

0.393

COQ7_HUMAN

5-demethoxyubiquinone hydroxylase, mitochondrial

0.393

MIO_HUMAN

GATOR complex protein MIOS

0.394

DC1I2_HUMAN

Cytoplasmic dynein 1 intermediate chain 2

0.394

LMA2L_HUMAN

VIP36-like protein

0.394

CACP_HUMAN

Carnitine O-acetyltransferase

0.395

HIP1_HUMAN

Huntingtin-interacting protein 1

0.395

LA_HUMAN

Lupus La protein

0.395

COR1B_HUMAN

Coronin-1B

0.395

SNX3_HUMAN

Sorting nexin-3

0.396

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.397

COR1A_HUMAN

Coronin-1A

0.398

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.398

MPIP3_HUMAN

M-phase inducer phosphatase 3

0.399

PYC_HUMAN

Pyruvate carboxylase, mitochondrial

0.399

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 120 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy