GNAT2_HUMAN 2019

Gene Name GNAT2

Description Guanine nucleotide-binding protein G(t) subunit alpha-2

Length 354

9606

Sequence

>sp|P19087|GNAT2_HUMAN Guanine nucleotide-binding protein G(t) subunit alpha-2
MGSGASAEDKELAKRSKELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDGYSPEECLEFKAIIYGNVLQSILAIIRAMTTLGIDYAEPSCADDGRQLNNLADSIEEGTMPPELVEVIRRLWKDGGVQACFERAAEYQLNDSASYYLNQLERITDPEYLPSEQDVLRSRVKTTGIIETKFSVKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEVNRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEEKIKKVHLSICFPEYDGNNSYDDAGNYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

GNAZ_HUMAN

Guanine nucleotide-binding protein G(z) subunit alpha

0.217

GNAT1_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-1

0.238

GNAT3_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-3

0.261

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GNAZ_HUMAN

Guanine nucleotide-binding protein G(z) subunit alpha

0.162

GNAT3_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-3

0.193

GNAT1_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-1

0.195

SH3Y1_HUMAN

SH3 domain-containing YSC84-like protein 1

0.278

GBB3_HUMAN

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

0.300

MSMO1_HUMAN

Methylsterol monooxygenase 1

0.316

FDFT_HUMAN

Squalene synthase

0.320

ERG7_HUMAN

Lanosterol synthase

0.323

CP51A_HUMAN

Lanosterol 14-alpha demethylase

0.324

ERG1_HUMAN

Squalene monooxygenase

0.330

GTR5_HUMAN

Solute carrier family 2, facilitated glucose transporter member 5

0.331

THIK_HUMAN

3-ketoacyl-CoA thiolase, peroxisomal

0.335

NSDHL_HUMAN

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.335

OTC_HUMAN

Ornithine carbamoyltransferase, mitochondrial

0.341

HLTF_HUMAN

Helicase-like transcription factor

0.343

AL1A3_HUMAN

Aldehyde dehydrogenase family 1 member A3

0.343

ACER3_HUMAN

Alkaline ceramidase 3

0.347

MRS2_HUMAN

Magnesium transporter MRS2 homolog, mitochondrial

0.347

M3K2_HUMAN

Mitogen-activated protein kinase kinase kinase 2

0.348

AMPD1_HUMAN

AMP deaminase 1

0.350

SERC5_HUMAN

Serine incorporator 5

0.350

GTR9_HUMAN

Solute carrier family 2, facilitated glucose transporter member 9

0.351

CMBL_HUMAN

Carboxymethylenebutenolidase homolog

0.352

S47A1_HUMAN

Multidrug and toxin extrusion protein 1

0.352

AL1A1_HUMAN

Retinal dehydrogenase 1

0.352

GNAO_HUMAN

Guanine nucleotide-binding protein G(o) subunit alpha

0.354

GNAI2_HUMAN

Guanine nucleotide-binding protein G(i) subunit alpha-2

0.354

VA0D2_HUMAN

V-type proton ATPase subunit d 2

0.355

STXB3_HUMAN

Syntaxin-binding protein 3

0.355

M3K3_HUMAN

Mitogen-activated protein kinase kinase kinase 3

0.357

GNAI3_HUMAN

Guanine nucleotide-binding protein G(k) subunit alpha

0.358

NADC_HUMAN

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

0.360

GDC_HUMAN

Graves disease carrier protein

0.360

GNAI1_HUMAN

Guanine nucleotide-binding protein G(i) subunit alpha-1

0.362

VPP3_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 3

0.363

DECR2_HUMAN

Peroxisomal 2,4-dienoyl-CoA reductase

0.365

S47A2_HUMAN

Multidrug and toxin extrusion protein 2

0.367

PIR_HUMAN

Pirin

0.368

TRUB1_HUMAN

Probable tRNA pseudouridine synthase 1

0.368

SC5D_HUMAN

Lathosterol oxidase

0.370

ADCK2_HUMAN

Uncharacterized aarF domain-containing protein kinase 2

0.370

GTR11_HUMAN

Solute carrier family 2, facilitated glucose transporter member 11

0.372

CBWD3_HUMAN

COBW domain-containing protein 3

0.372

CBWD2_HUMAN

COBW domain-containing protein 2

0.372

CBWD5_HUMAN

COBW domain-containing protein 5

0.372

CBWD1_HUMAN

COBW domain-containing protein 1

0.372

VPP2_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 2

0.372

PPGB_HUMAN

Lysosomal protective protein

0.373

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.373

AL1A2_HUMAN

Retinal dehydrogenase 2

0.373

RANG_HUMAN

Ran-specific GTPase-activating protein

0.373

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.375

WDFY4_HUMAN

WD repeat- and FYVE domain-containing protein 4

0.376

ARLY_HUMAN

Argininosuccinate lyase

0.378

CBWD6_HUMAN

COBW domain-containing protein 6

0.378

DHX29_HUMAN

ATP-dependent RNA helicase DHX29

0.378

IPO11_HUMAN

Importin-11

0.379

MAOM_HUMAN

NAD-dependent malic enzyme, mitochondrial

0.380

PPID_HUMAN

Peptidyl-prolyl cis-trans isomerase D

0.380

AMPD3_HUMAN

AMP deaminase 3

0.380

DNPEP_HUMAN

Aspartyl aminopeptidase

0.380

ERG28_HUMAN

Probable ergosterol biosynthetic protein 28

0.381

GTR7_HUMAN

Solute carrier family 2, facilitated glucose transporter member 7

0.381

TBA8_HUMAN

Tubulin alpha-8 chain

0.383

EPAB2_HUMAN

Embryonic polyadenylate-binding protein 2

0.383

TBB3_HUMAN

Tubulin beta-3 chain

0.384

CSK22_HUMAN

Casein kinase II subunit alpha

0.384

SELO_HUMAN

Protein adenylyltransferase SelO, mitochondrial

0.384

GSHR_HUMAN

Glutathione reductase, mitochondrial

0.384

CATE_HUMAN

Cathepsin E

0.385

HYES_HUMAN

Bifunctional epoxide hydrolase 2

0.386

CLPB_HUMAN

Caseinolytic peptidase B protein homolog

0.386

XPOT_HUMAN

Exportin-T

0.387

PLPP4_HUMAN

Phospholipid phosphatase 4

0.388

LAAT1_HUMAN

Lysosomal amino acid transporter 1 homolog

0.388

OVGP1_HUMAN

Oviduct-specific glycoprotein

0.389

CD123_HUMAN

Cell division cycle protein 123 homolog

0.389

ORML3_HUMAN

ORM1-like protein 3

0.389

NALDL_HUMAN

Aminopeptidase NAALADL1

0.390

PEX7_HUMAN

Peroxisomal targeting signal 2 receptor

0.390

TBB6_HUMAN

Tubulin beta-6 chain

0.391

H31_HUMAN

Histone H3.1

0.392

TBA4A_HUMAN

Tubulin alpha-4A chain

0.392

MRP2_HUMAN

Canalicular multispecific organic anion transporter 1

0.392

ADT4_HUMAN

ADP/ATP translocase 4

0.392

THNS2_HUMAN

Threonine synthase-like 2

0.393

AK1A1_HUMAN

Aldo-keto reductase family 1 member A1

0.393

AIFM2_HUMAN

Apoptosis-inducing factor 2

0.393

ELOV5_HUMAN

Elongation of very long chain fatty acids protein 5

0.394

ORML2_HUMAN

ORM1-like protein 2

0.394

SETX_HUMAN

Probable helicase senataxin

0.394

PLD2_HUMAN

Phospholipase D2

0.394

HEM3_HUMAN

Porphobilinogen deaminase

0.394

ORML1_HUMAN

ORM1-like protein 1

0.395

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.395

RBBP7_HUMAN

Histone-binding protein RBBP7

0.395

AP1M2_HUMAN

AP-1 complex subunit mu-2

0.395

HEM6_HUMAN

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

0.395

IAH1_HUMAN

Isoamyl acetate-hydrolyzing esterase 1 homolog

0.395

TKTL1_HUMAN

Transketolase-like protein 1

0.396

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.396

GRPE2_HUMAN

GrpE protein homolog 2, mitochondrial

0.396

AP1S3_HUMAN

AP-1 complex subunit sigma-3

0.397

MTHR_HUMAN

Methylenetetrahydrofolate reductase

0.397

ACTC_HUMAN

Actin, alpha cardiac muscle 1

0.397

UBP10_HUMAN

Ubiquitin carboxyl-terminal hydrolase 10

0.397

NADK_HUMAN

NAD kinase

0.398

MEF2B_HUMAN

Myocyte-specific enhancer factor 2B

0.398

VP26A_HUMAN

Vacuolar protein sorting-associated protein 26A

0.398

ASSY_HUMAN

Argininosuccinate synthase

0.398

ACTH_HUMAN

Actin, gamma-enteric smooth muscle

0.398

WDR76_HUMAN

WD repeat-containing protein 76

0.399

ELOV2_HUMAN

Elongation of very long chain fatty acids protein 2

0.399

PLSI_HUMAN

Plastin-1

0.399

PUR2_HUMAN

Trifunctional purine biosynthetic protein adenosine-3

0.399

PLD1_HUMAN

Phospholipase D1

0.399

NB5R2_HUMAN

NADH-cytochrome b5 reductase 2

0.399

THTR_HUMAN

Thiosulfate sulfurtransferase

0.399

ACTA_HUMAN

Actin, aortic smooth muscle

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 102 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy