DBNL_HUMAN 2019

Gene Name DBNL

Description Drebrin-like protein

Length 430

9606

Sequence

>sp|Q9UJU6|DBNL_HUMAN Drebrin-like protein
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SOS2_HUMAN

Son of sevenless homolog 2

0.390

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.329

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.340

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.343

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.351

SOS1_HUMAN

Son of sevenless homolog 1

0.351

KMT5B_HUMAN

Histone-lysine N-methyltransferase KMT5B

0.351

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.351

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.351

SOS2_HUMAN

Son of sevenless homolog 2

0.356

GOLP3_HUMAN

Golgi phosphoprotein 3

0.357

DPP4_HUMAN

Dipeptidyl peptidase 4

0.357

SURF4_HUMAN

Surfeit locus protein 4

0.360

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.363

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.364

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.364

HIP1_HUMAN

Huntingtin-interacting protein 1

0.364

PAXI_HUMAN

Paxillin

0.364

VIGLN_HUMAN

Vigilin

0.364

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.365

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.365

STRP1_HUMAN

Striatin-interacting protein 1

0.366

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.367

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.367

SEPR_HUMAN

Prolyl endopeptidase FAP

0.368

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.369

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.369

CUL1_HUMAN

Cullin-1

0.371

ZNT1_HUMAN

Zinc transporter 1

0.371

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.372

S39A9_HUMAN

Zinc transporter ZIP9

0.374

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.375

QPCTL_HUMAN

Glutaminyl-peptide cyclotransferase-like protein

0.375

NPRL2_HUMAN

GATOR complex protein NPRL2

0.375

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.376

S2536_HUMAN

Solute carrier family 25 member 36

0.377

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.378

GDE_HUMAN

Glycogen debranching enzyme

0.379

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.379

PBDC1_HUMAN

Protein PBDC1

0.379

CACP_HUMAN

Carnitine O-acetyltransferase

0.380

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.381

PEX13_HUMAN

Peroxisomal membrane protein PEX13

0.381

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.382

SEPT7_HUMAN

Septin-7

0.383

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.385

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.385

SNX12_HUMAN

Sorting nexin-12

0.386

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.387

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.388

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.388

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.388

SRF_HUMAN

Serum response factor

0.388

POMT2_HUMAN

Protein O-mannosyl-transferase 2

0.389

GATA4_HUMAN

Transcription factor GATA-4

0.389

DYR_HUMAN

Dihydrofolate reductase

0.389

SNX3_HUMAN

Sorting nexin-3

0.390

STRP2_HUMAN

Striatin-interacting protein 2

0.391

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.391

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.393

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.393

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.394

RHOA_HUMAN

Transforming protein RhoA

0.394

NIPS2_HUMAN

Protein NipSnap homolog 2

0.394

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.394

TSC2_HUMAN

Tuberin

0.395

S2533_HUMAN

Solute carrier family 25 member 33

0.396

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.396

ERGI2_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 2

0.396

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.397

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.398

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.398

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 90 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy