NP1L2_HUMAN 2019

Gene Name NP1L2

Description Nucleosome assembly protein 1-like 2

Length 460

9606

Sequence

>sp|Q9ULW6|NP1L2_HUMAN Nucleosome assembly protein 1-like 2
MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDDGKCGEEAAAGLGEEGENGEDTAAGSGEDGKKGGDTDEDSEADRPKGLIGYVLDTDFVESLPVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYEPTEEECEYKSDSEDCDDEEMCHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEEEEEDDIEATGEENKEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGITSNGRDGNDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDAIYDKIIYDNWMAAIEEVKACCKNLEALVEDIDR

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ADT4_HUMAN

ADP/ATP translocase 4

0.323

TKTL1_HUMAN

Transketolase-like protein 1

0.337

AP1G2_HUMAN

AP-1 complex subunit gamma-like 2

0.345

NP1L4_HUMAN

Nucleosome assembly protein 1-like 4

0.348

CLH2_HUMAN

Clathrin heavy chain 2

0.353

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.353

AP1M2_HUMAN

AP-1 complex subunit mu-2

0.356

H31_HUMAN

Histone H3.1

0.358

TBA4A_HUMAN

Tubulin alpha-4A chain

0.359

RBBP7_HUMAN

Histone-binding protein RBBP7

0.360

CERS3_HUMAN

Ceramide synthase 3

0.360

P4R3C_HUMAN

Protein PPP4R3C

0.362

DNPEP_HUMAN

Aspartyl aminopeptidase

0.365

TBB4A_HUMAN

Tubulin beta-4A chain

0.365

GSK3A_HUMAN

Glycogen synthase kinase-3 alpha

0.366

CERS4_HUMAN

Ceramide synthase 4

0.368

NP1L1_HUMAN

Nucleosome assembly protein 1-like 1

0.370

CNNM3_HUMAN

Metal transporter CNNM3

0.373

VA0D2_HUMAN

V-type proton ATPase subunit d 2

0.373

TBA1C_HUMAN

Tubulin alpha-1C chain

0.374

CANB2_HUMAN

Calcineurin subunit B type 2

0.374

BECN2_HUMAN

Beclin-2

0.374

GRPE2_HUMAN

GrpE protein homolog 2, mitochondrial

0.376

TBA3E_HUMAN

Tubulin alpha-3E chain

0.376

SE1L2_HUMAN

Protein sel-1 homolog 2

0.376

TOP1M_HUMAN

DNA topoisomerase I, mitochondrial

0.377

H2B3B_HUMAN

Histone H2B type 3-B

0.377

VATB1_HUMAN

V-type proton ATPase subunit B, kidney isoform

0.377

VPP4_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 4

0.378

H2B1A_HUMAN

Histone H2B type 1-A

0.378

HDAC1_HUMAN

Histone deacetylase 1

0.379

ERD21_HUMAN

ER lumen protein-retaining receptor 1

0.379

CSK22_HUMAN

Casein kinase II subunit alpha

0.380

TBA3C_HUMAN

Tubulin alpha-3C chain

0.380

VP26A_HUMAN

Vacuolar protein sorting-associated protein 26A

0.381

PAP1L_HUMAN

Polyadenylate-binding protein 1-like

0.381

MAOM_HUMAN

NAD-dependent malic enzyme, mitochondrial

0.381

VATC2_HUMAN

V-type proton ATPase subunit C 2

0.382

ERD23_HUMAN

ER lumen protein-retaining receptor 3

0.382

NAA16_HUMAN

N-alpha-acetyltransferase 16, NatA auxiliary subunit

0.383

MRP2_HUMAN

Canalicular multispecific organic anion transporter 1

0.383

TBA3D_HUMAN

Tubulin alpha-3D chain

0.384

TECRL_HUMAN

Trans-2,3-enoyl-CoA reductase-like

0.384

NACAD_HUMAN

NAC-alpha domain-containing protein 1

0.385

VATE2_HUMAN

V-type proton ATPase subunit E 2

0.386

BCAT2_HUMAN

Branched-chain-amino-acid aminotransferase, mitochondrial

0.386

IDHP_HUMAN

Isocitrate dehydrogenase [NADP], mitochondrial

0.387

LPIN3_HUMAN

Phosphatidate phosphatase LPIN3

0.388

RAB6C_HUMAN

Ras-related protein Rab-6C

0.388

RAB6D_HUMAN

Ras-related protein Rab-6D

0.388

KCC1B_HUMAN

Calcium/calmodulin-dependent protein kinase type 1B

0.389

NB5R1_HUMAN

NADH-cytochrome b5 reductase 1

0.389

RL3L_HUMAN

60S ribosomal protein L3-like

0.389

U2AF4_HUMAN

Splicing factor U2AF 26 kDa subunit

0.389

H2A1B_HUMAN

Histone H2A type 1-B/E

0.389

MON1B_HUMAN

Vacuolar fusion protein MON1 homolog B

0.390

ANM1_HUMAN

Protein arginine N-methyltransferase 1

0.390

2AAB_HUMAN

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

0.391

HS71A_HUMAN

Heat shock 70 kDa protein 1A

0.391

HS71B_HUMAN

Heat shock 70 kDa protein 1B

0.391

TBA1B_HUMAN

Tubulin alpha-1B chain

0.391

TBB3_HUMAN

Tubulin beta-3 chain

0.391

HS71L_HUMAN

Heat shock 70 kDa protein 1-like

0.391

TBB2A_HUMAN

Tubulin beta-2A chain

0.391

RAB5B_HUMAN

Ras-related protein Rab-5B

0.391

CC50B_HUMAN

Cell cycle control protein 50B

0.392

PYRG2_HUMAN

CTP synthase 2

0.392

AK1A1_HUMAN

Aldo-keto reductase family 1 member A1

0.392

PRPS3_HUMAN

Ribose-phosphate pyrophosphokinase 3

0.392

S61A2_HUMAN

Protein transport protein Sec61 subunit alpha isoform 2

0.392

H2AJ_HUMAN

Histone H2A.J

0.393

TBB5_HUMAN

Tubulin beta chain

0.393

ADT1_HUMAN

ADP/ATP translocase 1

0.393

AL1A1_HUMAN

Retinal dehydrogenase 1

0.394

AG1L2_HUMAN

Putative glycosyltransferase ALG1L2

0.394

S14L5_HUMAN

SEC14-like protein 5

0.394

KDM5C_HUMAN

Lysine-specific demethylase 5C

0.394

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.395

DX39A_HUMAN

ATP-dependent RNA helicase DDX39A

0.395

TCPW_HUMAN

T-complex protein 1 subunit zeta-2

0.395

H2A1C_HUMAN

Histone H2A type 1-C

0.395

NB5R2_HUMAN

NADH-cytochrome b5 reductase 2

0.396

H2A2A_HUMAN

Histone H2A type 2-A

0.396

SYF1_HUMAN

Pre-mRNA-splicing factor SYF1

0.396

TBB2B_HUMAN

Tubulin beta-2B chain

0.396

GDIB_HUMAN

Rab GDP dissociation inhibitor beta

0.397

PP1A_HUMAN

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

0.397

KPYR_HUMAN

Pyruvate kinase PKLR

0.397

ENOB_HUMAN

Beta-enolase

0.397

COPG1_HUMAN

Coatomer subunit gamma-1

0.398

PR40B_HUMAN

Pre-mRNA-processing factor 40 homolog B

0.398

RIR2B_HUMAN

Ribonucleoside-diphosphate reductase subunit M2 B

0.398

H2A3_HUMAN

Histone H2A type 3

0.398

COQ8B_HUMAN

Atypical kinase COQ8B, mitochondrial

0.398

AP1B1_HUMAN

AP-1 complex subunit beta-1

0.398

COPZ2_HUMAN

Coatomer subunit zeta-2

0.398

EFTU_HUMAN

Elongation factor Tu, mitochondrial

0.399

YPEL3_HUMAN

Protein yippee-like 3

0.399

ATG9B_HUMAN

Autophagy-related protein 9B

0.399

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.399

WDR5B_HUMAN

WD repeat-containing protein 5B

0.399

VPS4A_HUMAN

Vacuolar protein sorting-associated protein 4A

0.399

CISY_HUMAN

Citrate synthase, mitochondrial

0.399

TPC6A_HUMAN

Trafficking protein particle complex subunit 6A

0.399

ASF1B_HUMAN

Histone chaperone ASF1B

0.399

IF5A2_HUMAN

Eukaryotic translation initiation factor 5A-2

0.399

H2A2B_HUMAN

Histone H2A type 2-B

0.399

NCB2L_HUMAN

Nuclear cap-binding protein subunit 2-like

0.400

CAND2_HUMAN

Cullin-associated NEDD8-dissociated protein 2

0.400

ATP7B_HUMAN

Copper-transporting ATPase 2

0.400

TKTL2_HUMAN

Transketolase-like protein 2

0.400

MPPB_HUMAN

Mitochondrial-processing peptidase subunit beta

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 114 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy